Detailed information NTG1170234

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACLV7Z_RS10160
• Genome accession: NZ_OZ217343
• Coordinates: 2036690..2037439 (-)
• Length: 249 a.a.
• NCBI ID: WP_173253425.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis G22
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2031690..2042439

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Z_RS10145 (SMIG22_20070)	-	2033687..2035048 (+)	1362	WP_218773989.1	bacteriocin secretion accessory protein	-
ACLV7Z_RS10150 (SMIG22_20080)	blpC	2035105..2035245 (+)	141	WP_112444774.1	quorum-sensing system pheromone BlpC	-
ACLV7Z_RS10155 (SMIG22_20090)	-	2035352..2036686 (-)	1335	WP_218757325.1	sensor histidine kinase	-
ACLV7Z_RS10160 (SMIG22_20100)	comE/blpR	2036690..2037439 (-)	750	WP_173253425.1	response regulator transcription factor	Regulator
ACLV7Z_RS10165 (SMIG22_20110)	-	2037436..2037783 (-)	348	WP_218757326.1	LytTR family transcriptional regulator DNA-binding domain-containing protein	-
ACLV7Z_RS10170 (SMIG22_20120)	-	2037967..2038353 (+)	387	WP_225904702.1	hypothetical protein	-
ACLV7Z_RS10175 (SMIG22_20130)	-	2038499..2039977 (-)	1479	WP_101514822.1	ABC transporter substrate-binding protein	-
ACLV7Z_RS10180	-	2040036..2040161 (+)	126	WP_411882180.1	hypothetical protein	-
ACLV7Z_RS10185 (SMIG22_20140)	-	2040234..2041157 (-)	924	WP_000818348.1	carbohydrate ABC transporter permease	-
ACLV7Z_RS10190 (SMIG22_20150)	-	2041170..2042099 (-)	930	WP_218773988.1	ABC transporter permease	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29301.84 Da
• Isoelectric Point: 5.8701

>NTDB_id=1170234 ACLV7Z_RS10160 WP_173253425.1 2036690..2037439(-) (comE/blpR) [Streptococcus mitis isolate S. mitis G22]
MNIFILEDDFIQQTRMENLVYDILEKNCWEVKHCGVYGKPNQLLEDMMERGGHQLFFLDIEIKNDVRKGLDIALEIRDRD
PNAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPESSFRERVEKAIAYVHKNKHQLMTEDSFVFTNSKALVQVPFSDLLY
IETSMIPHKLVLYSMRERIEFYGKISDILKQEPRLVQCHRSFIVNPYNISSIDKEEKLVYLKNGSSCLVSRLKMRELLNI
VKDLHDSKE

Nucleotide

• Length: 750 bp

>NTDB_id=1170234 ACLV7Z_RS10160 WP_173253425.1 2036690..2037439(-) (comE/blpR) [Streptococcus mitis isolate S. mitis G22]
ATGAATATCTTTATATTAGAGGATGATTTTATACAGCAGACTAGGATGGAAAATCTGGTGTATGATATTTTAGAGAAGAA
TTGTTGGGAAGTAAAGCACTGTGGTGTTTATGGTAAACCGAATCAATTGTTAGAAGATATGATGGAACGTGGAGGTCATC
AACTTTTCTTTTTGGATATTGAAATTAAAAACGATGTTAGAAAAGGGTTAGATATTGCTTTGGAAATCAGAGATAGAGAT
CCAAATGCAGTCATTGTTTTTGTAACAACTCATTCAGAATTTATGCCTGTTAGTTTTCAATATCAAGTATCAGCTTTAGA
TTTTATTGATAAGGAATTACCTGAAAGCTCTTTTAGGGAACGTGTGGAAAAGGCAATCGCTTATGTTCACAAGAATAAAC
ATCAACTAATGACTGAAGATTCTTTTGTGTTTACAAATTCTAAAGCACTCGTTCAGGTTCCGTTTTCGGATTTGCTTTAT
ATAGAAACGTCAATGATTCCTCATAAGCTAGTTCTTTATTCTATGAGAGAAAGAATAGAGTTTTACGGTAAAATTTCTGA
TATATTGAAGCAAGAACCCAGATTGGTTCAGTGTCATCGTTCTTTTATTGTGAATCCTTATAATATCTCTTCAATAGATA
AGGAAGAAAAACTAGTCTATTTGAAGAACGGGTCAAGTTGCCTAGTATCTAGGTTAAAAATGAGGGAATTGCTGAATATA
GTTAAAGATTTACATGATAGTAAGGAGTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (150-240)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	51.406	100	0.514
comE/comE1	Streptococcus equinus JB1	41.597	95.582	0.398
comE/comE2	Streptococcus gordonii strain NCTC7865	39.431	98.795	0.39
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.431	98.795	0.39
comE/comE2	Streptococcus equinus JB1	37.705	97.992	0.369