Detailed information NTG1170213

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: ACLV7Z_RS06660
• Genome accession: NZ_OZ217343
• Coordinates: 1300068..1302308 (-)
• Length: 746 a.a.
• NCBI ID: WP_218773951.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis G22
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1295068..1307308

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Z_RS06625 (SMIG22_12980)	-	1295972..1296352 (-)	381	WP_218773954.1	VOC family protein	-
ACLV7Z_RS06630 (SMIG22_12990)	rplT	1296411..1296770 (-)	360	WP_000124834.1	50S ribosomal protein L20	-
ACLV7Z_RS06635 (SMIG22_13000)	rpmI	1296822..1297022 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
ACLV7Z_RS06640 (SMIG22_13010)	infC	1297055..1297585 (-)	531	WP_000848180.1	translation initiation factor IF-3	-
ACLV7Z_RS06645 (SMIG22_13030)	-	1297893..1299077 (-)	1185	WP_218773953.1	hypothetical protein	-
ACLV7Z_RS06650 (SMIG22_13040)	-	1299081..1299668 (-)	588	WP_176139747.1	ABC transporter ATP-binding protein	-
ACLV7Z_RS06655	-	1299701..1299889 (-)	189	WP_218773952.1	hypothetical protein	-
ACLV7Z_RS06660 (SMIG22_13050)	comEC/celB	1300068..1302308 (-)	2241	WP_218773951.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ACLV7Z_RS06665 (SMIG22_13060)	comEA/celA/cilE	1302292..1302942 (-)	651	WP_218773950.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACLV7Z_RS06670 (SMIG22_13070)	-	1303008..1303577 (-)	570	WP_218773949.1	GNAT family N-acetyltransferase	-
ACLV7Z_RS06675 (SMIG22_13080)	-	1303685..1304689 (-)	1005	WP_218773948.1	PhoH family protein	-
ACLV7Z_RS06680 (SMIG22_13090)	-	1304775..1304990 (-)	216	WP_001232084.1	YozE family protein	-
ACLV7Z_RS06685 (SMIG22_13100)	cvfB	1304999..1305853 (-)	855	WP_001095439.1	RNA-binding virulence regulatory protein CvfB	-
ACLV7Z_RS06690 (SMIG22_13110)	frr	1305913..1306470 (-)	558	WP_001262225.1	ribosome recycling factor	-
ACLV7Z_RS06695 (SMIG22_13120)	pyrH	1306478..1307215 (-)	738	WP_031222472.1	UMP kinase	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84882.31 Da
• Isoelectric Point: 9.3680

>NTDB_id=1170213 ACLV7Z_RS06660 WP_218773951.1 1300068..1302308(-) (comEC/celB) [Streptococcus mitis isolate S. mitis G22]
MLQWIKNFPLPLIYLSFLLLWLYYAIFSASYLALLGFVFLIVCLFFQFPWKSAGKVLMICGVFGFWFLFQNWQQSRASQN
LADSVERVRILPDTIKVNGDSLSFRGKSDGRIFQVYYKLQSEEEKEAFQALTDLYDLELEGKLSEPEGQRNFGGFDYQVY
LKTQGIYKTLNIKRIQSLKQVRSWDIGENLSSLRRKSVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDGFKKLLLRLGLTQEKLKWLIYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFII
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVARESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFSLSFLYPVIQLNFIFEWLEGMIRLVSQMTSRPFVFGQPNAWFLILLLISLALVYDLRKNIKRLAVLSLLITGLFFLTK
HPLENEITMLDVGQGESIFLRDVTGKSILIDVGGKVESDKKIEAWQEKATTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKEFVAELEATKTKVRSVTVGENLPIFGSQLEVLSPRKIGDGGHEDSLILYGKL
LDKHFLFTGNLEEKGEKDMLKQYPDLEVDVLKASQHGSKKSSSSAFLEQLKPEMTLISVGKNNRTKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGWNSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=1170213 ACLV7Z_RS06660 WP_218773951.1 1300068..1302308(-) (comEC/celB) [Streptococcus mitis isolate S. mitis G22]
ATGTTACAGTGGATTAAGAATTTCCCCCTTCCCCTAATCTATCTGAGTTTTCTGTTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCCTATCTTGCTTTGTTGGGCTTTGTTTTTCTGATTGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCGG
GCAAAGTTCTAATGATTTGTGGAGTCTTTGGATTCTGGTTTCTGTTTCAAAATTGGCAACAGAGTCGAGCGAGTCAAAAT
TTGGCGGATTCTGTTGAAAGGGTACGGATTTTACCAGACACTATTAAGGTCAATGGTGACAGTCTATCCTTTCGTGGCAA
GTCTGATGGACGCATTTTTCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACAGATC
TTTATGACTTGGAACTAGAAGGAAAACTTTCGGAGCCAGAGGGGCAGAGGAATTTTGGTGGCTTTGACTACCAAGTCTAT
CTGAAGACTCAGGGAATTTACAAGACTCTCAATATAAAAAGAATCCAGTCACTTAAACAAGTTCGCAGTTGGGATATAGG
TGAAAACCTGTCCAGTTTACGTCGAAAGTCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGAAATTATATGA
CAGGGCTCTTGTTAGGACATTTGGACACTGACTTTGAGGAGATGAATGAGCTTTATTCTAGTCTAGGAATTATCCACCTT
TTTGCCTTGTCGGGTATGCAGGTAGGCTTTTTCATGGATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGATTTATCCCTTTTCCCTTATCTATGCAGGGCTGACAGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAGAAGCTACTGGCTCAACATGGTGTTAAGGGCTTGGATAATTTTGCCTTGACTGTGCTTGTACTCTTTATTATC
ATGCCCAACTTTTTCCTGACTGCAGGAGGAGTTTTGTCATGTGCTTATGCTTTTATCTTGACTATGACTAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGAGAAAGTCTGGTTATTTCTTTGGGAATATTACCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCCATCCTCTTGACCTTTGTCTTTTCCTTTCTATTTGATTTGGTCTTCTTACCGCTCTTGTCTATC
TTATTTTCCCTTTCCTTTCTCTATCCAGTCATTCAACTGAATTTTATCTTTGAATGGTTGGAGGGAATGATTCGCTTGGT
CTCGCAGATGACAAGTAGGCCGTTTGTCTTTGGACAACCTAATGCATGGTTTTTAATTTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAAGGCTAGCAGTATTGAGTTTATTAATTACAGGTCTCTTTTTCCTGACCAAA
CATCCACTGGAAAATGAAATTACCATGCTGGATGTTGGGCAAGGCGAAAGTATTTTCCTACGGGATGTAACTGGTAAGAG
CATTCTCATAGATGTCGGTGGCAAGGTAGAATCTGATAAGAAAATTGAGGCTTGGCAAGAAAAGGCGACGACCAGCAATG
CCCAGCGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCCAAGATTGACCAGCTAATTTTGACCAACACGGACAAG
GAACATGTTGGAGATTTGTTGGAGGTGACCAAGGCTTTTCATGTAGGGGAGATTTTAGTGTCCAAAGGCAGTTTGAAACA
GAAGGAATTTGTTGCAGAACTAGAGGCTACTAAAACAAAGGTGCGCAGTGTGACAGTTGGAGAGAACTTGCCAATTTTCG
GAAGTCAGTTAGAAGTCCTATCTCCAAGGAAAATTGGAGACGGAGGTCATGAAGATTCCCTGATTTTGTATGGGAAACTC
TTGGATAAGCACTTTCTCTTCACAGGAAATTTGGAGGAGAAAGGAGAGAAGGACATGCTGAAGCAATATCCTGACCTAGA
GGTGGATGTTTTGAAAGCTAGCCAACATGGCTCTAAAAAATCATCAAGTTCAGCCTTTTTAGAACAGCTCAAACCAGAGA
TGACTCTCATCTCAGTTGGAAAGAACAATCGAACGAAACTCCCCCATCAGGAAACTTTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGGTTTAAAGGTTGGAATAGTTGGAAAATCGAAAGCGTTCGATA
G

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (30-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	93.164	100	0.932
comEC/celB	Streptococcus mitis NCTC 12261	91.812	99.866	0.917
comEC/celB	Streptococcus pneumoniae Rx1	90.483	100	0.905
comEC/celB	Streptococcus pneumoniae D39	90.483	100	0.905
comEC/celB	Streptococcus pneumoniae R6	90.483	100	0.905
comEC/celB	Streptococcus pneumoniae TIGR4	90.483	100	0.905
comEC	Lactococcus lactis subsp. cremoris KW2	45.479	99.33	0.452