Detailed information
Bioinformatically predicted
Overview
| Name | comA | Type | Regulator |
| Locus tag | ACLV7Z_RS00310 | Genome accession | NZ_OZ217343 |
| Coordinates | 61708..63861 (+) | Length | 717 a.a. |
| NCBI ID | WP_218774344.1 | Uniprot ID | - |
| Organism | Streptococcus mitis isolate S. mitis G22 | ||
| Function | processing and transport of ComC (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 26206..81696 | 61708..63861 | within | 0 |
Gene organization within MGE regions
Location: 26206..81696
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACLV7Z_RS00150 (SMIG22_00270) | - | 26206..27021 (+) | 816 | WP_218774367.1 | PrsW family intramembrane metalloprotease | - |
| ACLV7Z_RS00155 (SMIG22_00280) | - | 27167..28135 (+) | 969 | WP_176139889.1 | ribose-phosphate diphosphokinase | - |
| ACLV7Z_RS00160 (SMIG22_00290) | - | 28253..29116 (+) | 864 | WP_218774366.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| ACLV7Z_RS00165 (SMIG22_00300) | - | 29482..30393 (+) | 912 | WP_218774365.1 | cell wall-binding protein | - |
| ACLV7Z_RS00170 | - | 30895..31743 (+) | 849 | Protein_26 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| ACLV7Z_RS00175 | - | 31741..32100 (+) | 360 | WP_411882183.1 | hypothetical protein | - |
| ACLV7Z_RS00180 (SMIG22_00320) | - | 32401..33567 (-) | 1167 | WP_218774363.1 | IS30 family transposase | - |
| ACLV7Z_RS00185 (SMIG22_00330) | - | 33780..35840 (+) | 2061 | WP_218774362.1 | LPXTG cell wall anchor domain-containing protein | - |
| ACLV7Z_RS00190 (SMIG22_00340) | - | 36055..37185 (-) | 1131 | WP_218774361.1 | tyrosine-type recombinase/integrase | - |
| ACLV7Z_RS00195 (SMIG22_00350) | - | 37240..37581 (-) | 342 | WP_218774360.1 | DUF771 domain-containing protein | - |
| ACLV7Z_RS00200 (SMIG22_00360) | - | 37639..38880 (-) | 1242 | WP_218774359.1 | replication protein RepA | - |
| ACLV7Z_RS00205 (SMIG22_00370) | - | 39069..39686 (-) | 618 | WP_218774358.1 | hypothetical protein | - |
| ACLV7Z_RS00210 (SMIG22_00380) | - | 39683..40849 (-) | 1167 | WP_218774357.1 | cell division protein FtsK | - |
| ACLV7Z_RS00215 (SMIG22_00390) | - | 40853..41209 (-) | 357 | WP_218774356.1 | hypothetical protein | - |
| ACLV7Z_RS00220 (SMIG22_00400) | - | 41394..41978 (+) | 585 | WP_218774355.1 | hypothetical protein | - |
| ACLV7Z_RS00225 (SMIG22_00410) | - | 42003..42344 (-) | 342 | WP_218774354.1 | helix-turn-helix domain-containing protein | - |
| ACLV7Z_RS00230 (SMIG22_00420) | - | 42552..45356 (+) | 2805 | WP_218774353.1 | SEC10/PgrA surface exclusion domain-containing protein | - |
| ACLV7Z_RS00235 (SMIG22_00430) | - | 45389..46282 (+) | 894 | WP_218774352.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| ACLV7Z_RS00240 (SMIG22_00440) | - | 46309..46950 (+) | 642 | WP_218774351.1 | hypothetical protein | - |
| ACLV7Z_RS00245 (SMIG22_00450) | - | 47211..48467 (-) | 1257 | WP_218774350.1 | ISL3 family transposase | - |
| ACLV7Z_RS00250 (SMIG22_00460) | - | 48747..49646 (-) | 900 | WP_218774349.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| ACLV7Z_RS00255 (SMIG22_00470) | polA | 49794..52427 (+) | 2634 | WP_218774348.1 | DNA polymerase I | - |
| ACLV7Z_RS00260 (SMIG22_00480) | - | 52512..52949 (+) | 438 | WP_000076477.1 | CoA-binding protein | - |
| ACLV7Z_RS00265 (SMIG22_00490) | - | 52980..53990 (-) | 1011 | WP_218774347.1 | YeiH family protein | - |
| ACLV7Z_RS00270 (SMIG22_00500) | - | 54139..55308 (+) | 1170 | WP_000366354.1 | pyridoxal phosphate-dependent aminotransferase | - |
| ACLV7Z_RS00275 (SMIG22_00510) | recO | 55305..56075 (+) | 771 | WP_000616135.1 | DNA repair protein RecO | - |
| ACLV7Z_RS00280 (SMIG22_00520) | plsX | 56072..57064 (+) | 993 | WP_218774346.1 | phosphate acyltransferase PlsX | - |
| ACLV7Z_RS00285 (SMIG22_00530) | - | 57070..57303 (+) | 234 | WP_000136446.1 | acyl carrier protein | - |
| ACLV7Z_RS00290 (SMIG22_00540) | - | 57754..58923 (+) | 1170 | WP_218774345.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| ACLV7Z_RS00295 | - | 59081..59263 (+) | 183 | Protein_51 | LytTR family transcriptional regulator DNA-binding domain-containing protein | - |
| ACLV7Z_RS00300 (SMIG22_00550) | - | 60207..60395 (+) | 189 | WP_000180826.1 | class IIb bacteriocin, lactobin A/cerein 7B family | - |
| ACLV7Z_RS00305 (SMIG22_00560) | - | 60604..60783 (+) | 180 | WP_176139940.1 | Blp family class II bacteriocin | - |
| ACLV7Z_RS00310 (SMIG22_00570) | comA | 61708..63861 (+) | 2154 | WP_218774344.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| ACLV7Z_RS00315 (SMIG22_00580) | comB | 63874..65223 (+) | 1350 | WP_218774343.1 | competence pheromone export protein ComB | Regulator |
| ACLV7Z_RS00320 (SMIG22_00590) | purC | 65393..66100 (+) | 708 | WP_218774342.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| ACLV7Z_RS00325 | - | 66325..66390 (+) | 66 | Protein_57 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| ACLV7Z_RS00330 (SMIG22_00600) | - | 66445..70170 (+) | 3726 | WP_218774341.1 | phosphoribosylformylglycinamidine synthase | - |
| ACLV7Z_RS00335 (SMIG22_00610) | purF | 70264..71706 (+) | 1443 | WP_218774340.1 | amidophosphoribosyltransferase | - |
| ACLV7Z_RS00340 (SMIG22_00620) | purM | 71921..72940 (+) | 1020 | WP_218774339.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| ACLV7Z_RS00345 (SMIG22_00630) | purN | 72937..73482 (+) | 546 | WP_218774338.1 | phosphoribosylglycinamide formyltransferase | - |
| ACLV7Z_RS00350 (SMIG22_00640) | - | 73566..74075 (+) | 510 | WP_218774337.1 | VanZ family protein | - |
| ACLV7Z_RS00355 (SMIG22_00650) | purH | 74100..75647 (+) | 1548 | WP_218774336.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
| ACLV7Z_RS00360 (SMIG22_00660) | purD | 75769..77034 (+) | 1266 | WP_218774335.1 | phosphoribosylamine--glycine ligase | - |
| ACLV7Z_RS00365 | - | 77234..77350 (+) | 117 | WP_411882145.1 | phosphoribosylaminoimidazole carboxylase | - |
| ACLV7Z_RS00370 (SMIG22_00670) | purE | 77382..77873 (+) | 492 | WP_218774334.1 | 5-(carboxyamino)imidazole ribonucleotide mutase | - |
| ACLV7Z_RS00375 (SMIG22_00680) | purK | 77860..78951 (+) | 1092 | WP_225904896.1 | 5-(carboxyamino)imidazole ribonucleotide synthase | - |
| ACLV7Z_RS00380 (SMIG22_00690) | - | 78961..79209 (+) | 249 | WP_218774371.1 | phosphoribosylaminoimidazole carboxylase | - |
| ACLV7Z_RS00385 (SMIG22_00700) | - | 79237..80109 (+) | 873 | WP_218774333.1 | viroplasmin family protein | - |
| ACLV7Z_RS00390 (SMIG22_00710) | - | 80120..81307 (+) | 1188 | WP_218774332.1 | type II toxin-antitoxin system RnlA family toxin | - |
| ACLV7Z_RS00395 (SMIG22_00720) | - | 81334..81696 (+) | 363 | WP_218774331.1 | type II toxin-antitoxin system RnlB family antitoxin | - |
Sequence
Protein
Download Length: 717 a.a. Molecular weight: 80313.37 Da Isoelectric Point: 6.4566
>NTDB_id=1170165 ACLV7Z_RS00310 WP_218774344.1 61708..63861(+) (comA) [Streptococcus mitis isolate S. mitis G22]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVYYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYHTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVYYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYHTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS
Nucleotide
Download Length: 2154 bp
>NTDB_id=1170165 ACLV7Z_RS00310 WP_218774344.1 61708..63861(+) (comA) [Streptococcus mitis isolate S. mitis G22]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGCTATTATTCTTTGGCTCACTTGCGAGAATTGGCCAAGACGACCATGGATGGGACTACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCAATTAAGGCGGATATGACGCTTTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCTGAAGAATGGACAGGAG
TGACCCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGCCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCGACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGTTGGGGATTATTTCTATTGGGCTGGTGA
TTGTTTATATTCTTCAGCAGATCTTGTCTTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTTTTTGCGACACGTCGGACAGGGGAAATCGTGTC
TCGTTTTACAGATGCTAACAGTATTATCGATGCGCTGGCTTCAACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCTCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCACTTCCTATCTATACAGTG
ATTATCTTTGCTTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCGTCTAT
CATTGAGGACATCAATGGTATTGAGACTATCAAGTCTTTGACCAGTGAGAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACTTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTACTTAATGTCGGAATTCTTTGGATGGGGGCTGTTCTGGTCATGGATGGTAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTTGTTTACTTTACCAATCCTTTGGAAAACATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTGAATGAGGTTTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACGGTCGAGGATTTGAGCTTGATG
AAGGGAGAGATGACTTTCAAGCAGGTTTACTATAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTGACTAT
TCCGCAGGGTTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACCTTGGCCAAGATGATGGTTAATTTTT
ACGACCCTAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAATACATA
AACTACCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTCCTTGGAGCCAAGGAAGGGACGAC
TCAAGAGGATATCTTACGGGCGGTGGAATTGGCAGAGATTAGGGAGGACATTGAGCGCATGCCACTGAATTACCATACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGGCAGAGAATCGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAAGCGACCAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTTGATAATCTCATGGCTTT
AGATAAGACCTTGATTTTCATCGCCCACCGCTTGACCATTGCAGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTGAATAGCTAG
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGCTATTATTCTTTGGCTCACTTGCGAGAATTGGCCAAGACGACCATGGATGGGACTACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCAATTAAGGCGGATATGACGCTTTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCTGAAGAATGGACAGGAG
TGACCCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGCCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCGACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGTTGGGGATTATTTCTATTGGGCTGGTGA
TTGTTTATATTCTTCAGCAGATCTTGTCTTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTTTTTGCGACACGTCGGACAGGGGAAATCGTGTC
TCGTTTTACAGATGCTAACAGTATTATCGATGCGCTGGCTTCAACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCTCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCACTTCCTATCTATACAGTG
ATTATCTTTGCTTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCGTCTAT
CATTGAGGACATCAATGGTATTGAGACTATCAAGTCTTTGACCAGTGAGAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACTTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTACTTAATGTCGGAATTCTTTGGATGGGGGCTGTTCTGGTCATGGATGGTAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTTGTTTACTTTACCAATCCTTTGGAAAACATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTGAATGAGGTTTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACGGTCGAGGATTTGAGCTTGATG
AAGGGAGAGATGACTTTCAAGCAGGTTTACTATAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTGACTAT
TCCGCAGGGTTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACCTTGGCCAAGATGATGGTTAATTTTT
ACGACCCTAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAATACATA
AACTACCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTCCTTGGAGCCAAGGAAGGGACGAC
TCAAGAGGATATCTTACGGGCGGTGGAATTGGCAGAGATTAGGGAGGACATTGAGCGCATGCCACTGAATTACCATACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGGCAGAGAATCGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAAGCGACCAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTTGATAATCTCATGGCTTT
AGATAAGACCTTGATTTTCATCGCCCACCGCTTGACCATTGCAGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTGAATAGCTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comA | Streptococcus mitis SK321 |
99.163 |
100 |
0.992 |
| comA | Streptococcus mitis NCTC 12261 |
99.024 |
100 |
0.99 |
| comA | Streptococcus pneumoniae Rx1 |
98.745 |
100 |
0.987 |
| comA | Streptococcus pneumoniae D39 |
98.745 |
100 |
0.987 |
| comA | Streptococcus pneumoniae R6 |
98.745 |
100 |
0.987 |
| comA | Streptococcus pneumoniae TIGR4 |
98.326 |
100 |
0.983 |
| comA | Streptococcus gordonii str. Challis substr. CH1 |
80.614 |
100 |
0.806 |
| comA/nlmT | Streptococcus mutans UA159 |
64.993 |
100 |
0.65 |