Detailed information NTG1170148

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACLV65_RS09795
• Genome accession: NZ_OZ217342
• Coordinates: 1961575..1962324 (-)
• Length: 249 a.a.
• NCBI ID: WP_112444770.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis B22
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1955221..1963238	1961575..1962324	within	0

Gene organization within MGE regions

Location: 1955221..1963238

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV65_RS09760 (SMIB22_19230)	-	1955221..1955439 (-)	219	WP_173213201.1	hypothetical protein	-
ACLV65_RS09765 (SMIB22_19240)	-	1955445..1955819 (-)	375	WP_173213199.1	immunity protein	-
ACLV65_RS09770 (SMIB22_19250)	-	1955871..1956098 (-)	228	WP_173220077.1	Blp family class II bacteriocin	-
ACLV65_RS09775 (SMIB22_19260)	comA/nlmT	1956408..1958561 (+)	2154	WP_411865145.1	peptide cleavage/export ABC transporter BlpA	Regulator
ACLV65_RS09780 (SMIB22_19270)	-	1958572..1959933 (+)	1362	WP_411865146.1	bacteriocin secretion accessory protein	-
ACLV65_RS09785 (SMIB22_19280)	blpC	1959990..1960130 (+)	141	WP_112444774.1	quorum-sensing system pheromone BlpC	-
ACLV65_RS09790 (SMIB22_19290)	-	1960237..1961571 (-)	1335	WP_411865147.1	sensor histidine kinase	-
ACLV65_RS09795 (SMIB22_19300)	comE/blpR	1961575..1962324 (-)	750	WP_112444770.1	response regulator transcription factor	Regulator
ACLV65_RS09800 (SMIB22_19310)	-	1962321..1962668 (-)	348	WP_112444768.1	LytTR family DNA-binding domain-containing protein	-
ACLV65_RS09805 (SMIB22_19320)	-	1962852..1963238 (+)	387	WP_225904702.1	hypothetical protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29227.80 Da
• Isoelectric Point: 6.0966

>NTDB_id=1170148 ACLV65_RS09795 WP_112444770.1 1961575..1962324(-) (comE/blpR) [Streptococcus mitis isolate S. mitis B22]
MNIFILEDDFIQQTRMENLVYDILEKNCWEVKHCGVYGKPNQLLEDMMERGGHQLFFLDIEIKNDVRKGLDIALEIRDRD
PNAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPESAFRERVEKAIAYVHKNKHQLMTEDSFVFTNSKALVQVPFSDLLY
IETSMIPHKLVLYSMRERIEFYGKISDILKQEPRLVQCHRSFIVNPYNISSIDKEEKLVYLKNGSSCLVSRLKMRALLNI
VKDLHDSKE

Nucleotide

• Length: 750 bp

>NTDB_id=1170148 ACLV65_RS09795 WP_112444770.1 1961575..1962324(-) (comE/blpR) [Streptococcus mitis isolate S. mitis B22]
ATGAATATCTTTATATTAGAGGATGATTTTATACAGCAGACTAGGATGGAAAATCTGGTGTATGATATTTTAGAGAAGAA
TTGTTGGGAAGTAAAGCACTGTGGTGTTTATGGTAAACCGAATCAATTGTTAGAAGATATGATGGAACGTGGAGGTCATC
AACTTTTCTTTTTGGATATTGAAATTAAAAACGATGTTAGAAAAGGGTTAGATATTGCTTTGGAAATCAGAGATAGAGAT
CCAAATGCAGTCATTGTTTTTGTAACAACTCATTCAGAATTTATGCCTGTTAGTTTTCAATATCAAGTATCAGCTTTAGA
TTTTATTGATAAGGAATTACCTGAAAGTGCTTTTAGGGAACGTGTGGAAAAGGCAATCGCTTATGTTCACAAGAATAAAC
ATCAACTAATGACTGAAGATTCTTTTGTATTTACAAATTCTAAAGCACTCGTTCAGGTTCCATTTTCGGATTTGCTTTAT
ATAGAAACGTCAATGATTCCTCATAAGCTAGTTCTTTATTCTATGAGAGAAAGAATAGAGTTTTACGGTAAAATTTCTGA
TATATTGAAGCAAGAACCCAGATTGGTTCAGTGTCATCGTTCTTTTATTGTGAATCCTTATAATATCTCTTCAATAGATA
AGGAAGAAAAACTAGTCTATTTGAAGAACGGGTCAAGTTGCCTAGTATCTAGGTTAAAAATGAGGGCATTGCTGAATATA
GTTAAAGATTTACATGATAGTAAGGAGTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (150-240)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	51.406	100	0.514
comE/comE1	Streptococcus equinus JB1	42.017	95.582	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.024	98.795	0.386
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.024	98.795	0.386
comE/comE2	Streptococcus equinus JB1	38.115	97.992	0.373