Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ACLV65_RS04310 Genome accession   NZ_OZ217342
Coordinates   847522..848259 (+) Length   245 a.a.
NCBI ID   WP_094753379.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis B22     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 842522..853259
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV65_RS04290 (SMIB22_08350) - 842616..843719 (+) 1104 WP_411864633.1 glycosyltransferase -
  ACLV65_RS04295 (SMIB22_08360) - 843721..844707 (+) 987 WP_411864634.1 glycosyltransferase family 2 protein -
  ACLV65_RS04300 (SMIB22_08370) - 844723..846192 (+) 1470 WP_411864635.1 O-antigen polysaccharide polymerase Wzy family protein -
  ACLV65_RS04305 (SMIB22_08380) - 846185..847219 (+) 1035 WP_411864636.1 prephenate dehydratase -
  ACLV65_RS04310 (SMIB22_08390) mecA 847522..848259 (+) 738 WP_094753379.1 adaptor protein MecA Regulator
  ACLV65_RS04315 (SMIB22_08400) - 848411..849697 (+) 1287 WP_411864637.1 homoserine dehydrogenase -
  ACLV65_RS04320 (SMIB22_08410) thrB 849699..850568 (+) 870 WP_050242142.1 homoserine kinase -
  ACLV65_RS04325 (SMIB22_08420) - 850644..850811 (+) 168 WP_411864638.1 hypothetical protein -
  ACLV65_RS04330 (SMIB22_08430) msrB 850872..851810 (+) 939 WP_411864639.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28422.19 Da        Isoelectric Point: 3.9915

>NTDB_id=1170120 ACLV65_RS04310 WP_094753379.1 847522..848259(+) (mecA) [Streptococcus mitis isolate S. mitis B22]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPESFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAQTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMNHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1170120 ACLV65_RS04310 WP_094753379.1 847522..848259(+) (mecA) [Streptococcus mitis isolate S. mitis B22]
ATGAAAATGAAACAAATTAGTGATACAACTTTGAAAATCACGATGTCTTTAGAAGATTTGATGGATCGAGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGAGAGCT
TTTTGGATACAGGCATGCTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTCGATGTCTTTGTAACCAAATCAAAGATT
GACCAAAATCTAGATTTTGAAGATTTATCGGATTTACCAGATATGGAAGAATTAGCTCAAATGTCGCCTGATGAATTTAT
CAAAACCTTGGAAAAAAGTATCGCGGACAAAACTAAGGATGACATCGAAGCCATTCAATCTTTAGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAGGAGCAGGCTGAACAAGAAGCTGAGAGCAAGAAAGAGCCTTACATCTATTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTGGCTTTTGCTCAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTCTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTTTTGGCCCGTATGCGCGAGT
TTGCGGACGATAGTGACATCAGTCGCTCGGTCTTACAAGAGTATGGTCAAGTCTTGATGAATCACGATGCAGTACTTAAT
CTGCAAAAGATTGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

98.367

100

0.984
  mecA Streptococcus pneumoniae D39

98.367

100

0.984
  mecA Streptococcus pneumoniae R6

98.367

100

0.984
  mecA Streptococcus pneumoniae TIGR4

97.959

100

0.98
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment