Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   ACLV7Q_RS09815 Genome accession   NZ_OZ217341
Coordinates   2024920..2025669 (-) Length   249 a.a.
NCBI ID   WP_173253425.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis C22     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2019920..2030669
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7Q_RS09800 (SMIC22_19390) - 2021917..2023278 (+) 1362 WP_193550504.1 bacteriocin secretion accessory protein -
  ACLV7Q_RS09805 (SMIC22_19400) blpC 2023335..2023475 (+) 141 WP_112444774.1 quorum-sensing system pheromone BlpC -
  ACLV7Q_RS09810 (SMIC22_19410) - 2023582..2024916 (-) 1335 WP_218757325.1 sensor histidine kinase -
  ACLV7Q_RS09815 (SMIC22_19420) comE/blpR 2024920..2025669 (-) 750 WP_173253425.1 response regulator transcription factor Regulator
  ACLV7Q_RS09820 (SMIC22_19430) - 2025666..2026013 (-) 348 WP_218757326.1 LytTR family transcriptional regulator DNA-binding domain-containing protein -
  ACLV7Q_RS09825 (SMIC22_19440) - 2026197..2026583 (+) 387 WP_225904702.1 hypothetical protein -
  ACLV7Q_RS09830 (SMIC22_19450) - 2026729..2028207 (-) 1479 WP_173249822.1 ABC transporter substrate-binding protein -
  ACLV7Q_RS09835 (SMIC22_19460) - 2028311..2029234 (-) 924 WP_000818348.1 carbohydrate ABC transporter permease -
  ACLV7Q_RS09840 (SMIC22_19470) - 2029247..2030176 (-) 930 WP_218757327.1 ABC transporter permease -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29301.84 Da        Isoelectric Point: 5.8701

>NTDB_id=1170066 ACLV7Q_RS09815 WP_173253425.1 2024920..2025669(-) (comE/blpR) [Streptococcus mitis isolate S. mitis C22]
MNIFILEDDFIQQTRMENLVYDILEKNCWEVKHCGVYGKPNQLLEDMMERGGHQLFFLDIEIKNDVRKGLDIALEIRDRD
PNAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPESSFRERVEKAIAYVHKNKHQLMTEDSFVFTNSKALVQVPFSDLLY
IETSMIPHKLVLYSMRERIEFYGKISDILKQEPRLVQCHRSFIVNPYNISSIDKEEKLVYLKNGSSCLVSRLKMRELLNI
VKDLHDSKE

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1170066 ACLV7Q_RS09815 WP_173253425.1 2024920..2025669(-) (comE/blpR) [Streptococcus mitis isolate S. mitis C22]
ATGAATATCTTTATATTAGAGGATGATTTTATACAGCAGACTAGGATGGAAAATCTGGTGTATGATATTTTAGAGAAGAA
TTGTTGGGAAGTAAAGCACTGTGGTGTTTATGGTAAACCGAATCAATTGTTAGAAGATATGATGGAACGTGGAGGTCATC
AACTTTTCTTTTTGGATATTGAAATTAAAAACGATGTTAGAAAAGGGTTAGATATTGCTTTGGAAATCAGAGATAGAGAT
CCAAATGCAGTCATTGTTTTTGTAACAACTCATTCAGAATTTATGCCTGTTAGTTTTCAATATCAAGTATCAGCTTTAGA
TTTTATTGATAAGGAATTACCTGAAAGCTCTTTTAGGGAACGTGTGGAAAAGGCAATCGCTTATGTTCACAAGAATAAAC
ATCAACTAATGACTGAAGATTCTTTTGTGTTTACAAATTCTAAAGCACTCGTTCAGGTTCCGTTTTCGGATTTGCTTTAT
ATAGAAACGTCAATGATTCCTCATAAGCTAGTTCTTTATTCTATGAGAGAAAGAATAGAGTTTTACGGTAAAATTTCTGA
TATATTGAAGCAAGAACCCAGATTGGTTCAGTGTCATCGTTCTTTTATTGTGAATCCTTATAATATCTCTTCAATAGATA
AGGAAGAAAAACTAGTCTATTTGAAGAACGGGTCAAGTTGCCTAGTATCTAGGTTAAAAATGAGGGAATTGCTGAATATA
GTTAAAGATTTACATGATAGTAAGGAGTAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(150-240)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

51.406

100

0.514
  comE/comE1 Streptococcus equinus JB1

41.597

95.582

0.398
  comE/comE2 Streptococcus gordonii strain NCTC7865

39.431

98.795

0.39
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

39.431

98.795

0.39
  comE/comE2 Streptococcus equinus JB1

37.705

97.992

0.369

Multiple sequence alignment