Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   ACLV7H_RS01945 Genome accession   NZ_OZ217340
Coordinates   370571..372724 (-) Length   717 a.a.
NCBI ID   WP_045591842.1    Uniprot ID   A0A0F2CZ54
Organism   Streptococcus oralis isolate S. oralis A22     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 373254..384843 370571..372724 flank 530


Gene organization within MGE regions


Location: 370571..384843
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7H_RS01945 (SORA22_03840) comA/nlmT 370571..372724 (-) 2154 WP_045591842.1 peptide cleavage/export ABC transporter BlpA Regulator
  ACLV7H_RS01950 (SORA22_03850) - 373011..373238 (+) 228 WP_045591840.1 bacteriocin class II family protein -
  ACLV7H_RS01955 (SORA22_03860) - 373254..373646 (+) 393 WP_045591838.1 hypothetical protein -
  ACLV7H_RS01960 (SORA22_03870) - 373655..373873 (+) 219 WP_024056799.1 Blp family class II bacteriocin -
  ACLV7H_RS01965 (SORA22_03900) - 374947..375264 (+) 318 WP_236682220.1 hypothetical protein -
  ACLV7H_RS01970 (SORA22_03910) - 375694..375924 (+) 231 WP_045591835.1 Blp family class II bacteriocin -
  ACLV7H_RS01975 (SORA22_03920) - 375927..376052 (+) 126 WP_045591870.1 PncF family bacteriocin immunity protein -
  ACLV7H_RS01980 - 376501..376904 (+) 404 Protein_356 immunity protein -
  ACLV7H_RS01985 (SORA22_03940) - 377091..377270 (+) 180 WP_411866221.1 bacteriocin class II family protein -
  ACLV7H_RS01990 - 377283..377450 (+) 168 WP_152906313.1 bacteriocin -
  ACLV7H_RS01995 (SORA22_03950) - 377483..378151 (+) 669 WP_049537855.1 CPBP family intramembrane glutamic endopeptidase -
  ACLV7H_RS02000 - 378403..378617 (+) 215 Protein_360 hypothetical protein -
  ACLV7H_RS02005 (SORA22_03960) - 378810..379031 (+) 222 WP_411866222.1 leucocin A/sakacin P family class II bacteriocin -
  ACLV7H_RS02010 (SORA22_03970) - 379031..379327 (+) 297 WP_049537857.1 bacteriocin immunity protein -
  ACLV7H_RS02015 (SORA22_03980) - 379634..379819 (+) 186 WP_049537858.1 bacteriocin class II family protein -
  ACLV7H_RS02020 (SORA22_03990) - 379877..380071 (+) 195 WP_049537859.1 Blp family class II bacteriocin -
  ACLV7H_RS02025 (SORA22_04010) - 380919..381956 (+) 1038 WP_411866223.1 thioredoxin domain-containing protein -
  ACLV7H_RS02030 (SORA22_04020) blpM 382207..382462 (+) 256 Protein_366 two-peptide bacteriocin subunit BlpM -
  ACLV7H_RS02035 (SORA22_04030) - 382478..382681 (+) 204 WP_198459247.1 Blp family class II bacteriocin -
  ACLV7H_RS02040 (SORA22_04040) - 382925..383175 (+) 251 Protein_368 Blp family class II bacteriocin -
  ACLV7H_RS02045 (SORA22_04050) - 383191..383400 (+) 210 WP_000483697.1 Blp family class II bacteriocin -
  ACLV7H_RS02050 - 383977..384261 (+) 285 Protein_370 lysostaphin resistance A-like protein -
  ACLV7H_RS02055 (SORA22_04070) blpU 384613..384843 (+) 231 WP_411866224.1 bacteriocin-like peptide BlpU -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80739.71 Da        Isoelectric Point: 7.0451

>NTDB_id=1169947 ACLV7H_RS01945 WP_045591842.1 370571..372724(-) (comA/nlmT) [Streptococcus oralis isolate S. oralis A22]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADQTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLITYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISIGLVITYILQQVMGFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLNKYSILQTNLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLLSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPCKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNNMISQEDILKACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNSVIVLDQGKIIEVGSHQELMQEQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1169947 ACLV7H_RS01945 WP_045591842.1 370571..372724(-) (comA/nlmT) [Streptococcus oralis isolate S. oralis A22]
ATGACTTCTTATAAACGTACATTTGTTCCACAAATAGATGCTAGAGACTGTGGTGTTGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGATTTGAAACAAGGCCTGTTCAAGCAGATCAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATTGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACCAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCAAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTACTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTGGATGAGTATATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAATCGGTCTAGTTA
TCACTTATATCCTCCAACAAGTCATGGGCTTCTCCCGTGATTATCTCCTAACTGTTCTGAGTCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCTATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTAGATGTTTCTATTCTGA
TTCTTGTAGGAGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCCATTCCTATATACATGTTC
ATCATCTTTTCCTTTATGAAGCCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAACTCAATAAATATTCTATTTTACAAACGAATTTAAAACAAGGAACAAAGTTA
GTTCTTAATATACTCATCCTATGGTTTGGGGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTCCTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTCG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACTTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTGCAAAGGACATATTTCCATCAATCATCAGGATATTAAAAACATTGACAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCTCAACAAGCCTATATCTTTAATGGATCTATCTTGGAAAACTTAACCTTGGGCGGTAATAATATGATTAG
TCAAGAAGATATTCTAAAAGCTTGTGAATTAGCTGAAATCCGTCAAGATATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATAGCCCTCGCTCGTGCTCTCCTAACTAAAGCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAAGTTATAGATAATCTTATGTCTCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACTAATAGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGGAGTCATCAAGAGTTAATGCAGGAGCAGGGCTTCTACCATCATCTATTCAACAAATAA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(500-649)

ABC transporter transmembrane region (ABC_membrane)

(169-438)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2CZ54

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.308

99.721

0.721
  comA Streptococcus mitis NCTC 12261

66.339

99.442

0.66
  comA Streptococcus gordonii str. Challis substr. CH1

65.46

100

0.656
  comA Streptococcus pneumoniae Rx1

65.778

99.442

0.654
  comA Streptococcus pneumoniae D39

65.778

99.442

0.654
  comA Streptococcus pneumoniae R6

65.778

99.442

0.654
  comA Streptococcus mitis SK321

65.778

99.442

0.654
  comA Streptococcus pneumoniae TIGR4

65.498

99.442

0.651

Multiple sequence alignment