Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   U8955_RS08285 Genome accession   NZ_OY769914
Coordinates   1632710..1634863 (+) Length   717 a.a.
NCBI ID   WP_038804513.1    Uniprot ID   A0A7T2ZWS4
Organism   Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1623386..1632428 1632710..1634863 flank 282


Gene organization within MGE regions


Location: 1623386..1634863
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U8955_RS08205 (SDENT7746_08225) blpM 1623386..1623640 (-) 255 WP_038804497.1 two-peptide bacteriocin subunit BlpM -
  U8955_RS08210 (SDENT7746_08230) - 1623884..1624921 (-) 1038 WP_038804498.1 thioredoxin domain-containing protein -
  U8955_RS08215 (SDENT7746_08240) - 1625750..1625950 (-) 201 WP_038804500.1 bacteriocin class II family protein -
  U8955_RS08220 (SDENT7746_08245) - 1626239..1626535 (-) 297 WP_038804501.1 bacteriocin immunity protein -
  U8955_RS08225 (SDENT7746_08250) - 1626535..1626756 (-) 222 WP_001049877.1 leucocin A/sakacin P family class II bacteriocin -
  U8955_RS08230 (SDENT7746_08255) - 1626997..1627686 (-) 690 WP_038804502.1 CPBP family intramembrane glutamic endopeptidase -
  U8955_RS08235 (SDENT7746_08260) blpZ 1628011..1628259 (-) 249 WP_000276518.1 immunity protein BlpZ -
  U8955_RS08240 (SDENT7746_08265) - 1628339..1628557 (-) 219 WP_000438252.1 hypothetical protein -
  U8955_RS08245 (SDENT7746_08270) - 1628563..1628937 (-) 375 WP_038804503.1 hypothetical protein -
  U8955_RS08250 (SDENT7746_08275) - 1628971..1629165 (-) 195 WP_038804504.1 Blp family class II bacteriocin -
  U8955_RS08255 (SDENT7746_08280) - 1629393..1629797 (-) 405 WP_038804506.1 hypothetical protein -
  U8955_RS08260 (SDENT7746_08285) - 1629826..1630146 (-) 321 WP_000645118.1 hypothetical protein -
  U8955_RS08265 (SDENT7746_08290) - 1630161..1630388 (-) 228 WP_038804508.1 bacteriocin class II family protein -
  U8955_RS08270 (SDENT7746_08295) - 1630576..1630980 (-) 405 WP_038804509.1 hypothetical protein -
  U8955_RS08275 (SDENT7746_08305) - 1631708..1631911 (-) 204 WP_038804511.1 hypothetical protein -
  U8955_RS08280 (SDENT7746_08310) - 1632225..1632428 (-) 204 WP_038804512.1 Blp family class II bacteriocin -
  U8955_RS08285 (SDENT7746_08315) comA/nlmT 1632710..1634863 (+) 2154 WP_038804513.1 peptide cleavage/export ABC transporter BlpA Regulator

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80824.87 Da        Isoelectric Point: 7.9419

>NTDB_id=1161735 U8955_RS08285 WP_038804513.1 1632710..1634863(+) (comA/nlmT) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAANEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTRKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQAMSFSRDYLLTVLSQRLSID
VILAYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLLLDVSILILVGSVLLAQNPNLFLLSLISVPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLTKYSILQTNLKQGTKL
VLNIFILWFGAQLVMSSKISIGQLITFNTLLSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSNFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKEGDKVSLVGVSGSGKTTLAKMIVNFFDPYKGQITINRQDIKNIDKKILRRHI
NYLPQQAYIFNGSILENLTLGGNNMISQEDILKACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSALDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELIQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1161735 U8955_RS08285 WP_038804513.1 1632710..1634863(+) (comA/nlmT) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGACTTCTTATAAACGTACATTTGTTCCCCAAATAGATGCTAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCCAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCAAATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGGAAACTCCAACATTACTATGTTGTCTATCAAACAAGGAAAGACTA
TCTGATTATTGGTGATCCTGATCCTTCTGTAAAAATCACCAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTGAGCTTCCTCCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTAGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTGGATGAGTACATTCCAAATCAGATGAAATCAACTTTAGGAATTATCTCAATTGGTCTAATTA
TCACCTATATCCTCCAACAAGCCATGAGCTTCTCCAGAGATTATCTCCTAACTGTTCTGAGTCAGAGATTAAGCATTGAT
GTAATTTTGGCCTATATTCGTCATATCTTTGAACTTCCTATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGCTTCACAGATGCCAACTCTATTATAGATGCCTTAGCTTCTACCATTCTCTCTCTTCTTCTTGATGTTTCCATTCTGA
TCCTTGTAGGGAGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCCGTTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTTGAAAAAATGAACCACGATGTCATGCAAAGCAATTCTATGGTTAGTTCTGCCAT
TATCGAAGATATCAACGGGATCGAAACCATCAAGTCACTCACAAGTGAAGAAAATCGCTACCAAAATATTGACAGTGAAT
TTGTCGATTATTTGGAAAAATCCTTTAAACTTACTAAATATTCTATTTTACAAACTAATTTAAAGCAAGGAACAAAGTTA
GTTCTTAATATCTTTATCCTATGGTTTGGTGCTCAATTAGTCATGTCGAGTAAGATTTCTATCGGTCAGCTGATTACCTT
TAATACACTTCTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTACAAACTAAACTCCAATCTGCGAAGGTTG
CTAATAACCGCTTGAACGAGGTCTATTTAGTTGAATCTGAATTTCAAGTTCAAGAAAATCCTGTTCATTCAAATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATCAATCTAACAAT
TAAAGAAGGTGATAAGGTTAGCCTGGTTGGAGTTAGTGGTTCTGGTAAAACAACTCTAGCCAAAATGATTGTCAATTTCT
TTGACCCTTACAAAGGACAGATTACCATCAATCGTCAGGATATTAAAAATATTGATAAAAAAATCTTGCGACGTCATATT
AATTACCTGCCCCAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACCTTGGGCGGTAATAATATGATTAG
CCAAGAAGATATTCTAAAAGCTTGCGAATTAGCTGAAATCCGTCAAGATATTGAAAGAATGCCTATGGGCTATCAAACTC
AACTTTCTGATGGAGCAGGTCTGTCAGGAGGACAGAAGCAACGAATTGCTCTCGCTCGTGCTCTTTTAACTAAATCTCCT
GTTTTAATACTAGATGAAGCTACTAGTGCTCTCGATGTTTTGACTGAGAAAAAGGTTATAGATAATCTTATGTCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTAAGTATAGCCGAACGGACTAACCGTGTCATTGTTCTTGACCAGGGTA
AAATCATTGAAGTTGGTAGTCATCAAGAGTTAATACAGGCGCAAGGCTTCTACCATCATCTATTCAACAAATAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T2ZWS4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.329

99.721

0.711
  comA Streptococcus mitis NCTC 12261

65.919

99.442

0.656
  comA Streptococcus pneumoniae D39

65.358

99.442

0.65
  comA Streptococcus mitis SK321

65.358

99.442

0.65
  comA Streptococcus pneumoniae R6

65.358

99.442

0.65
  comA Streptococcus pneumoniae Rx1

65.358

99.442

0.65
  comA Streptococcus gordonii str. Challis substr. CH1

64.714

100

0.647
  comA Streptococcus pneumoniae TIGR4

65.077

99.442

0.647

Multiple sequence alignment