Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   U8955_RS06370 Genome accession   NZ_OY769914
Coordinates   1264518..1265258 (-) Length   246 a.a.
NCBI ID   WP_038805441.1    Uniprot ID   A0A7T2ZW54
Organism   Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1259518..1270258
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U8955_RS06355 (SDENT7746_06385) msrB 1261014..1261952 (-) 939 WP_038805437.1 peptide-methionine (R)-S-oxide reductase MsrB -
  U8955_RS06360 (SDENT7746_06390) thrB 1262213..1263082 (-) 870 WP_038805439.1 homoserine kinase -
  U8955_RS06365 (SDENT7746_06395) - 1263084..1264370 (-) 1287 WP_038805440.1 homoserine dehydrogenase -
  U8955_RS06370 (SDENT7746_06400) mecA 1264518..1265258 (-) 741 WP_038805441.1 adaptor protein MecA Regulator
  U8955_RS06375 (SDENT7746_06405) - 1265381..1266859 (+) 1479 WP_038805442.1 oligosaccharide flippase family protein -
  U8955_RS06380 (SDENT7746_06410) - 1266909..1269434 (-) 2526 WP_038805443.1 MBL fold metallo-hydrolase -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28580.43 Da        Isoelectric Point: 4.1173

>NTDB_id=1161728 U8955_RS06370 WP_038805441.1 1264518..1265258(-) (mecA) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MKMKQISDTTLKITMTLDDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDNFLDSGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLADLPDMEELAQMSPDEFLKTLEKSIAEKTKDDIEAIQSLEQVEAKEEEQEQANKETENKKEPYIYYILRFA
SLADLVAFAKTVTFEMETSELYKMNDHYYLTILVNIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQILINHDAVLG
LQKIRS

Nucleotide


Download         Length: 741 bp        

>NTDB_id=1161728 U8955_RS06370 WP_038805441.1 1264518..1265258(-) (mecA) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGAAGATGAAACAAATTAGTGATACAACACTGAAAATCACGATGACTTTAGATGATTTGATGGATCGAGGAATGGAAAT
TGCAGACTTTCTCGTTCCTCAGGAAAAAACCGAAGAGTTTTTCTATGCTATTTTAGATGAACTGGAAATGCCAGACAATT
TCTTGGATAGTGGCATGCTGAGTTTCCGTGTGACGCCAAAACCTGACAAGGTCGACGTCTTTGTGACCAAGTCCAAGATT
GACCAAAATCTGGATTTTGAAGATTTGGCGGATCTGCCGGATATGGAAGAATTGGCCCAAATGTCACCAGATGAATTTCT
CAAAACTCTGGAAAAAAGCATCGCAGAAAAGACCAAGGATGATATTGAGGCCATCCAATCTCTAGAACAGGTAGAAGCTA
AAGAAGAAGAGCAAGAGCAAGCGAACAAGGAGACGGAGAATAAGAAAGAACCTTATATCTACTACATCCTGCGCTTTGCA
AGCCTTGCTGACCTAGTGGCTTTTGCTAAAACAGTGACTTTTGAGATGGAAACATCTGAACTCTATAAGATGAATGACCA
CTATTATTTGACAATTTTAGTCAATATTGAAAATCATCCAAGTCCATACCCAGCTTGGCTCTTGGCTCGTATGCGTGAAT
TTGCAGACGACAGTGACATCAGTCGTTCAGTCTTGCAAGAGTATGGGCAAATATTGATTAACCATGACGCAGTTCTCGGT
CTGCAAAAGATTCGTTCATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-238)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T2ZW54

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

91.393

99.187

0.906
  mecA Streptococcus pneumoniae D39

91.393

99.187

0.906
  mecA Streptococcus pneumoniae R6

91.393

99.187

0.906
  mecA Streptococcus pneumoniae TIGR4

90.984

99.187

0.902
  mecA Streptococcus mutans UA159

49.18

99.187

0.488
  mecA Streptococcus thermophilus LMD-9

46.825

100

0.48
  mecA Streptococcus thermophilus LMG 18311

46.429

100

0.476

Multiple sequence alignment