Detailed information NTG1161710

Bioinformatically predicted

Overview

• Name: stkP
• Type: Regulator
• Locus tag: U8955_RS02415
• Genome accession: NZ_OY769914
• Coordinates: 459894..461777 (+)
• Length: 627 a.a.
• NCBI ID: WP_038804822.1
• Uniprot ID: A0A7T2ZYL1
• Organism: Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746
• Function: require for competence development; phosphorylate ComE (predicted from homology) Competence regulation

Genomic Context

Location: 454894..466777

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U8955_RS02400 (SDENT7746_02395)	fmt	456900..457835 (+)	936	WP_000163668.1	methionyl-tRNA formyltransferase	-
U8955_RS02405 (SDENT7746_02400)	rsmB	457828..459141 (+)	1314	WP_038805610.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
U8955_RS02410 (SDENT7746_02405)	-	459157..459897 (+)	741	WP_038804821.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
U8955_RS02415 (SDENT7746_02410)	stkP	459894..461777 (+)	1884	WP_038804822.1	Stk1 family PASTA domain-containing Ser/Thr kinase	Regulator
U8955_RS02420 (SDENT7746_02415)	-	461865..462623 (+)	759	WP_038804824.1	threonine/serine exporter family protein	-
U8955_RS02425 (SDENT7746_02420)	-	462625..463080 (+)	456	WP_038804825.1	threonine/serine exporter family protein	-
U8955_RS02430 (SDENT7746_02425)	-	463199..464371 (+)	1173	WP_038805611.1	hydroxymethylglutaryl-CoA synthase	-
U8955_RS02435 (SDENT7746_02430)	-	464371..465645 (+)	1275	WP_038804826.1	hydroxymethylglutaryl-CoA reductase, degradative	-
U8955_RS02440 (SDENT7746_02435)	-	465787..466752 (-)	966	WP_000225991.1	LacI family DNA-binding transcriptional regulator	-

Sequence

Protein

• Length: 627 a.a.
• Molecular weight: 68374.68 Da
• Isoelectric Point: 9.2160

>NTDB_id=1161710 U8955_RS02415 WP_038804822.1 459894..461777(+) (stkP) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MIQIGKIFAGRYRIIKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHSPLSNEEAVRIMGQILLAMRLAHTRGIIHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPAVP
QALENVVIKATAKKLTDRYQSVSEMYVDLSSCLSHNRRREPKLVFDEASKVDTKTLPKVPQSTLTSIPKAKPQLERPQSK
QQTQQVVDEAPVPKPAKKRKFKARYMILLASALLVAASLIWIFSRTPATIAIPDVSGQTVAEAKETLKKANFEVGEEKTE
ASDTVAEGRVIRTDPEARSGRKEGSKVNLIVSSGKQSFQLSNYVGRKSSDVVAELKEKKVPENLIKIEEEESSESDPGTV
IRQTPAAGSTYDLTKASTITLTVAKKVTSVSMPSYIGSSLEFTKNNLTQIVGVKEANIEVVEVSTAPEGTTAGTVVSQDP
KPGEKVDLNKTRVKISIYKPKPLPSSSSSSQHGNSGTDTTPSQSNNQGSNPTTDSSDGSRTSSNERN

Nucleotide

• Length: 1884 bp

>NTDB_id=1161710 U8955_RS02415 WP_038804822.1 459894..461777(+) (stkP) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGATCCAGATCGGCAAGATTTTTGCCGGACGATATCGGATTATCAAACAGATTGGTCGAGGAGGCATGGCGGATGTTTA
CTTGGCCAAGGATTTGATCCTAGACGGGGAAGAAGTGGCGGTTAAGGTCCTGAGGACTAACTATCAGACAGATCCGATTG
CTGTGGCACGTTTTCAACGTGAAGCGAGAGCCATGGCGGATCTGGATCATCCCCATATCGTTCGAATAACAGATATCGGT
GAAGAAGACGGTCAGCAGTATCTGGCTATGGAGTATGTGGCAGGGCTTGATCTCAAACGTTATATCAAAGAACACTCCCC
TCTCTCAAACGAAGAAGCCGTCCGTATTATGGGACAGATTCTCTTGGCGATGCGTCTGGCGCATACGAGAGGGATTATCC
ACCGAGATTTGAAACCTCAAAATATCCTATTGACACCAGATGGAACTGCCAAAGTTACAGACTTTGGGATTGCCGTGGCT
TTTGCAGAGACCAGTCTGACACAGACTAACTCCATGCTCGGTTCAGTCCACTATCTCTCACCTGAGCAGGCCCGTGGTTC
CAAGGCAACTGTGCAGAGTGACATCTATGCTATGGGGATTATTTTCTATGAGATGTTGACAGGACATATCCCTTATGATG
GGGATAGTGCAGTGACTATTGCCCTCCAGCATTTCCAAAAACCACTTCCATCTGTTATTGCTGAGAATCCAGCAGTACCA
CAAGCTTTGGAAAATGTTGTTATCAAGGCAACGGCCAAGAAATTGACAGATCGCTATCAGTCTGTATCAGAAATGTATGT
GGACTTGTCAAGTTGTTTGTCTCACAATCGTAGGAGAGAACCAAAGCTAGTCTTTGATGAGGCAAGCAAGGTTGATACCA
AGACCTTGCCTAAAGTTCCACAAAGCACTCTGACCTCTATTCCGAAGGCTAAGCCACAATTAGAGCGACCTCAATCAAAA
CAGCAGACTCAGCAGGTGGTAGATGAAGCACCAGTACCAAAACCAGCGAAAAAACGGAAGTTTAAAGCTCGCTACATGAT
TTTACTGGCCAGTGCCTTGCTAGTTGCAGCCTCTTTGATTTGGATCTTCTCCCGAACTCCAGCGACTATTGCTATTCCAG
ATGTATCGGGACAGACAGTTGCTGAAGCTAAAGAGACACTGAAGAAAGCTAATTTTGAAGTAGGTGAAGAAAAGACAGAG
GCCAGCGACACAGTAGCCGAAGGTCGCGTCATTCGAACAGATCCAGAAGCTAGAAGCGGTCGAAAAGAAGGAAGCAAAGT
AAATCTAATCGTTTCATCAGGTAAGCAATCCTTCCAACTAAGTAACTATGTAGGACGTAAGTCCTCGGATGTTGTCGCGG
AGCTCAAAGAGAAAAAGGTTCCAGAAAACCTCATTAAGATCGAGGAAGAGGAATCTAGCGAAAGCGATCCAGGAACAGTC
ATTAGGCAAACCCCAGCTGCAGGAAGCACTTACGATCTCACGAAAGCCAGCACGATTACCTTAACAGTTGCTAAGAAGGT
AACCAGCGTTTCGATGCCAAGTTACATTGGTTCAAGTCTCGAATTTACTAAGAACAATTTGACTCAGATTGTTGGTGTAA
AAGAGGCCAATATCGAAGTTGTGGAAGTATCAACTGCTCCTGAAGGAACTACTGCAGGAACAGTTGTTAGTCAGGACCCT
AAACCTGGAGAAAAGGTAGATCTCAATAAAACACGTGTTAAGATTTCTATTTATAAACCAAAACCACTTCCTTCTTCATC
AAGTTCGTCTCAACACGGAAATTCAGGAACAGACACGACGCCTTCACAGAGTAACAATCAAGGTAGCAACCCTACAACGG
ATTCTTCAGATGGCAGTAGAACGTCAAGTAATGAACGAAATTAA

Domains

Predicted by InterproScan.

• PASTA domain (PASTA) (441-505)

• PASTA domain (PASTA) (371-432)

• PASTA domain (PASTA) (510-579)

• Protein kinase domain (Pkinase) (12-227)

3D structure

• AlphaFold DB: A0A7T2ZYL1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
stkP	Streptococcus pneumoniae TIGR4	77.187	92.982	0.718
stkP	Streptococcus pneumoniae D39	76.844	92.982	0.715
stkP	Streptococcus pneumoniae R6	76.844	92.982	0.715
stkP	Streptococcus pneumoniae Rx1	76.672	92.982	0.713
pknB	Streptococcus mutans UA159	56.282	92.663	0.522
stkP/pknB	Streptococcus salivarius strain HSISS4	50.918	95.534	0.486