Detailed information NTG1160515

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: ACI6O7_RS01185
• Genome accession: NZ_OY725152
• Coordinates: 232177..234324 (+)
• Length: 715 a.a.
• NCBI ID: WP_404378906.1
• Uniprot ID: -
• Organism: Lactococcus lactis strain IMDO WA12L8
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	223848..249550	232177..234324	within	0

Gene organization within MGE regions

Location: 223848..249550

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACI6O7_RS01145 (LLWA12L8_FAMOGCFE_00232)	-	223848..225683 (+)	1836	WP_010905248.1	ABC transporter ATP-binding protein	-
ACI6O7_RS01150 (LLWA12L8_FAMOGCFE_00233)	-	225680..227557 (+)	1878	WP_404378898.1	ABC transporter ATP-binding protein	-
ACI6O7_RS01155 (LLWA12L8_FAMOGCFE_00234)	-	227654..228307 (+)	654	WP_010905251.1	YcjF family protein	-
ACI6O7_RS01160 (LLWA12L8_FAMOGCFE_00235)	-	228353..229372 (-)	1020	WP_017864067.1	Gfo/Idh/MocA family oxidoreductase	-
ACI6O7_RS01165 (LLWA12L8_FAMOGCFE_00236)	-	229356..229523 (-)	168	WP_003131184.1	hypothetical protein	-
ACI6O7_RS01170 (LLWA12L8_FAMOGCFE_00237)	-	229711..230187 (-)	477	WP_404378900.1	S-ribosylhomocysteine lyase	-
ACI6O7_RS01175 (LLWA12L8_FAMOGCFE_00238)	-	230397..231551 (-)	1155	WP_404378902.1	tyrosine-type recombinase/integrase	-
ACI6O7_RS01180 (LLWA12L8_FAMOGCFE_00239)	-	231642..231902 (+)	261	WP_404378904.1	hypothetical protein	-
ACI6O7_RS01185 (LLWA12L8_FAMOGCFE_00240)	comA	232177..234324 (+)	2148	WP_404378906.1	peptide cleavage/export ABC transporter	Regulator
ACI6O7_RS01190 (LLWA12L8_FAMOGCFE_00241)	-	234339..235760 (+)	1422	WP_404378908.1	HlyD family secretion protein	-
ACI6O7_RS01195 (LLWA12L8_FAMOGCFE_00242)	-	235890..236069 (+)	180	WP_336268551.1	lactococcin family bacteriocin	-
ACI6O7_RS01200 (LLWA12L8_FAMOGCFE_00243)	-	236231..236536 (+)	306	WP_404378910.1	hypothetical protein	-
ACI6O7_RS01205 (LLWA12L8_FAMOGCFE_00244)	-	237303..237767 (+)	465	WP_010905253.1	GyrI-like domain-containing protein	-
ACI6O7_RS01210 (LLWA12L8_FAMOGCFE_00245)	-	237832..238677 (+)	846	WP_003131189.1	aldo/keto reductase	-
ACI6O7_RS01215 (LLWA12L8_FAMOGCFE_00246)	-	238843..239355 (+)	513	WP_023189990.1	cysteine hydrolase family protein	-
ACI6O7_RS01220 (LLWA12L8_FAMOGCFE_00247)	-	239474..240022 (+)	549	WP_003131191.1	DUF6036 family nucleotidyltransferase	-
ACI6O7_RS01225 (LLWA12L8_FAMOGCFE_00248)	-	240019..240303 (+)	285	WP_003131192.1	hypothetical protein	-
ACI6O7_RS01230 (LLWA12L8_FAMOGCFE_00249)	-	240342..241661 (-)	1320	WP_012897088.1	LysM peptidoglycan-binding domain-containing protein	-
ACI6O7_RS01235 (LLWA12L8_FAMOGCFE_00250)	nrdD	242005..244248 (+)	2244	WP_010905257.1	anaerobic ribonucleoside-triphosphate reductase	-
ACI6O7_RS01240 (LLWA12L8_FAMOGCFE_00251)	nrdG	244245..244850 (+)	606	WP_025016575.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
ACI6O7_RS01245 (LLWA12L8_FAMOGCFE_00252)	-	244959..245465 (-)	507	WP_003131197.1	DUF2325 domain-containing protein	-
ACI6O7_RS01250 (LLWA12L8_FAMOGCFE_00253)	eno	245756..247024 (+)	1269	WP_404378914.1	phosphopyruvate hydratase	-
ACI6O7_RS01260 (LLWA12L8_FAMOGCFE_00255)	-	247322..248155 (+)	834	WP_012897143.1	energy-coupling factor ABC transporter ATP-binding protein	-
ACI6O7_RS01265 (LLWA12L8_FAMOGCFE_00256)	-	248199..248687 (+)	489	WP_050484020.1	GNAT family N-acetyltransferase	-
ACI6O7_RS01270 (LLWA12L8_FAMOGCFE_00257)	-	248684..249550 (+)	867	WP_012897144.1	energy-coupling factor ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 715 a.a.
• Molecular weight: 79891.36 Da
• Isoelectric Point: 7.9370

>NTDB_id=1160515 ACI6O7_RS01185 WP_404378906.1 232177..234324(+) (comA) [Lactococcus lactis strain IMDO WA12L8]
MKFKKKNYTQQVDEMDCGCAALSMILKSYGTEKSLASLRLLAGTTIEGTSALGIKKAGEGLDFAVQVLRADASLFEMKEV
PYPFIAHVIKDQKYPHYYVITGANKNSVFIADPDPTVKMTKLSKEVFLSEWTGISLFLSPTPSYQPTKEKASSLLSFIPI
ITRQKKVILNIVVASFIVTLINILGSYYLQSMIDSYIPNALMGTLGIISVGLLLTYIIQQVLEFAKTFLLNVLSQRLAID
VILSYIRHIFQLPMSFFSTRRTGEITSRFSDASSILDAIASTILSLFLDLTIVLMTGLILGVQNMQLFLLVLLAIPLYIV
VIIIFTPLFEKQNHEVMQTNSVLNSSIIEDINGIETIKALASEQERYQKIDYEFASYLKKAFTLQQSEAIQTAIKTTVQL
VLNVLVLWFGATLVIHQKITLGQLITFNALLSYFTNPITNIINLQTKLQKARVANERLNEVYLVPSEFEEKKTELSLAHF
NLNMSEISYQYGFGRKVLSEIKLSIKENEKLTIVGMSGSGKSTLVKLLVNFFQPTSGTITLGGIDLQQFDKHQLRRLINY
LPQQPYIFTGSILDNLLLGANDNTSQEEIIKAVELAEIRVDIEQMQLGYQTELSSDASSLSGGQKQRIALARALLSPAKI
LILDEATSNLDMITEKKILKNLLALDKTIIFIAHRLSVAEMSHRIIVIEQGKVIESGSHSELLAQNGFYAQLYHN

Nucleotide

• Length: 2148 bp

>NTDB_id=1160515 ACI6O7_RS01185 WP_404378906.1 232177..234324(+) (comA) [Lactococcus lactis strain IMDO WA12L8]
ATGAAATTTAAAAAGAAAAATTATACCCAACAAGTGGATGAAATGGACTGTGGCTGTGCTGCTTTATCAATGATTTTAAA
GTCTTATGGCACAGAAAAGTCACTCGCTTCATTGCGTTTACTTGCTGGCACAACAATCGAAGGAACTTCCGCTTTAGGAA
TAAAAAAAGCAGGAGAAGGTTTAGATTTCGCAGTTCAAGTATTAAGAGCAGATGCAAGCCTTTTTGAAATGAAGGAAGTC
CCTTACCCTTTTATTGCTCATGTTATTAAAGACCAAAAGTATCCACACTACTATGTGATAACTGGCGCAAATAAAAATTC
GGTATTCATCGCAGATCCTGACCCAACCGTTAAAATGACAAAACTTTCAAAAGAAGTTTTTTTATCGGAATGGACAGGCA
TTAGTTTATTTCTTTCGCCTACCCCATCTTATCAGCCCACTAAAGAAAAAGCTTCCTCATTATTATCTTTTATCCCAATT
ATCACCCGTCAAAAGAAAGTCATTCTCAATATTGTTGTTGCCTCATTCATTGTAACGCTGATTAATATTCTAGGCTCTTA
CTACCTCCAAAGTATGATTGATAGTTATATCCCAAATGCCTTAATGGGAACTTTAGGGATTATCTCAGTAGGACTATTAT
TGACTTATATTATCCAACAAGTCTTAGAGTTTGCTAAGACTTTCTTACTGAATGTTCTTTCTCAAAGATTAGCTATTGAT
GTCATTCTTTCTTATATTAGACACATTTTCCAACTTCCAATGTCTTTCTTTTCAACCCGAAGAACAGGAGAAATTACGAG
TCGGTTTTCTGATGCCAGTTCTATTTTAGATGCTATTGCTTCAACGATTCTTTCACTTTTTTTAGATTTGACGATTGTCC
TCATGACAGGACTAATTTTAGGCGTTCAAAATATGCAACTCTTTCTTCTCGTTCTTTTGGCAATCCCACTTTATATTGTT
GTTATTATTATTTTTACACCCCTTTTTGAAAAACAAAACCATGAAGTTATGCAGACCAATTCCGTCTTAAATTCTTCAAT
TATTGAAGACATTAATGGGATTGAAACCATCAAAGCGCTCGCCAGTGAACAAGAGAGATATCAAAAAATTGACTACGAAT
TTGCAAGTTATCTAAAAAAGGCTTTCACTTTACAACAGTCAGAAGCCATTCAGACGGCAATAAAAACGACAGTACAACTT
GTACTAAATGTTCTTGTTTTATGGTTTGGTGCAACTTTAGTCATACATCAAAAAATTACCCTCGGACAACTCATTACTTT
TAATGCCTTGCTTTCTTACTTTACAAATCCAATTACTAATATCATTAACCTTCAAACAAAACTACAAAAGGCAAGGGTAG
CCAATGAACGATTAAATGAGGTCTATCTTGTACCCAGTGAATTTGAAGAAAAGAAAACAGAACTGTCCCTCGCACATTTT
AATTTAAACATGTCTGAGATTTCATATCAATATGGTTTTGGCAGAAAAGTCTTATCTGAGATAAAACTATCTATTAAAGA
AAATGAAAAGTTGACCATTGTTGGTATGAGCGGTTCAGGGAAGAGTACTCTTGTTAAATTATTGGTCAACTTCTTTCAAC
CCACTTCTGGTACCATCACTTTAGGTGGAATTGACCTTCAACAGTTTGATAAACACCAACTCCGACGATTAATTAACTAT
CTTCCCCAACAACCTTATATTTTTACTGGTTCAATTTTAGATAATCTGCTTCTAGGAGCTAACGATAATACTTCGCAAGA
AGAGATTATTAAAGCGGTGGAATTGGCAGAAATCCGTGTGGACATTGAACAAATGCAGTTAGGCTATCAGACCGAACTTT
CAAGTGATGCAAGTAGTCTATCGGGAGGACAAAAACAACGAATTGCTTTAGCTCGTGCGCTCCTTTCTCCTGCCAAAATA
CTCATTTTAGATGAAGCTACCAGCAACCTAGATATGATTACTGAAAAGAAAATATTAAAGAATTTGTTGGCCTTGGATAA
AACCATTATTTTCATTGCCCACCGCCTCTCTGTGGCGGAAATGAGCCATCGTATCATTGTCATTGAACAAGGAAAAGTGA
TAGAAAGTGGTTCACATTCGGAACTGCTTGCTCAAAATGGCTTTTACGCACAACTTTACCATAACTAA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (6-142)

• ABC transporter (ABC_tran) (498-648)

• ABC transporter transmembrane region (ABC_membrane) (169-437)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus gordonii str. Challis substr. CH1	61.345	99.86	0.613
comA	Streptococcus mitis NCTC 12261	59.804	99.86	0.597
comA	Streptococcus mitis SK321	59.664	99.86	0.596
comA	Streptococcus pneumoniae Rx1	59.384	99.86	0.593
comA	Streptococcus pneumoniae D39	59.384	99.86	0.593
comA	Streptococcus pneumoniae R6	59.384	99.86	0.593
comA	Streptococcus pneumoniae TIGR4	59.104	99.86	0.59
comA/nlmT	Streptococcus mutans UA159	58.078	100	0.583