Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SMUFR_RS01230 Genome accession   NZ_CP007016
Coordinates   233728..234450 (+) Length   240 a.a.
NCBI ID   WP_002262749.1    Uniprot ID   Q8DW33
Organism   Streptococcus mutans UA159-FR     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 228728..239450
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUFR_RS01215 (SMUFR_0202) - 229129..230682 (-) 1554 WP_002262752.1 ABC transporter substrate-binding protein/permease -
  SMUFR_RS01220 (SMUFR_0203) - 230834..232735 (+) 1902 WP_002262751.1 DUF2207 domain-containing protein -
  SMUFR_RS01225 (SMUFR_0204) - 232793..233638 (+) 846 WP_002262750.1 undecaprenyl-diphosphate phosphatase -
  SMUFR_RS01230 (SMUFR_0205) mecA 233728..234450 (+) 723 WP_002262749.1 adaptor protein MecA Regulator
  SMUFR_RS01235 (SMUFR_0206) rgpG 234456..235616 (+) 1161 WP_002262748.1 rhamnose-glucose polysaccharide biosynthesis protein RgpB -
  SMUFR_RS01240 (SMUFR_0207) sufC 235690..236460 (+) 771 WP_002262747.1 Fe-S cluster assembly ATPase SufC -
  SMUFR_RS01245 (SMUFR_0208) sufD 236498..237760 (+) 1263 WP_002262746.1 Fe-S cluster assembly protein SufD -
  SMUFR_RS01250 (SMUFR_0209) - 237765..238994 (+) 1230 WP_002262745.1 cysteine desulfurase -
  SMUFR_RS01255 (SMUFR_0210) sufU 238981..239415 (+) 435 WP_002262744.1 Fe-S cluster assembly sulfur transfer protein SufU -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 28055.65 Da        Isoelectric Point: 4.2340

>NTDB_id=115742 SMUFR_RS01230 WP_002262749.1 233728..234450(+) (mecA) [Streptococcus mutans UA159-FR]
MEMKQISETTLKITISMEDLEERGMELKDFLIPQEKTEEFFYTVMDELDLPENFKDSGMLSFRVTPRNDRIDVFVTKSEI
NKNLNLEDLSDFDDISKMSPEDFFNTLEETMREKGDAAALDKLAEIEKREEEKTQQEKGETKEKRDYVHFVLDFPNIQQV
INFAKTVDYDVEASELFKESDAYHMTVLLNLEDKPDYYADLMFARMLEHAGRGTKTRAYLLEHGVQLIKADALQELQMIG

Nucleotide


Download         Length: 723 bp        

>NTDB_id=115742 SMUFR_RS01230 WP_002262749.1 233728..234450(+) (mecA) [Streptococcus mutans UA159-FR]
ATGGAAATGAAACAAATCAGCGAAACAACATTAAAAATCACCATCAGTATGGAAGATTTAGAAGAAAGAGGCATGGAATT
AAAAGATTTCTTGATTCCGCAGGAAAAGACGGAAGAATTTTTCTATACTGTTATGGATGAGCTGGACTTGCCTGAAAATT
TCAAGGACAGTGGGATGTTAAGCTTTCGAGTAACACCAAGGAATGATCGCATTGATGTTTTTGTCACTAAGTCAGAAATC
AATAAAAATCTTAATTTGGAGGATTTGTCTGATTTTGATGATATTTCAAAAATGTCTCCGGAGGATTTCTTTAATACCTT
GGAGGAAACCATGCGTGAAAAAGGGGATGCTGCAGCTCTGGATAAATTGGCTGAAATTGAAAAAAGAGAAGAAGAGAAGA
CTCAGCAGGAAAAAGGTGAAACTAAGGAAAAAAGAGATTACGTTCACTTTGTGCTGGATTTTCCTAATATTCAGCAAGTC
ATAAATTTTGCTAAGACAGTTGACTATGATGTAGAGGCTTCAGAACTTTTTAAGGAGTCTGACGCTTATCACATGACTGT
TCTGCTTAATCTCGAAGATAAACCCGACTATTATGCTGATCTTATGTTTGCAAGAATGTTGGAGCATGCTGGTAGAGGAA
CAAAGACACGTGCTTATCTATTAGAACATGGAGTTCAGCTCATTAAAGCAGATGCTCTGCAAGAATTACAAATGATTGGA
TAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-236)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DW33

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

100

100

1
  mecA Streptococcus thermophilus LMD-9

57.787

100

0.588
  mecA Streptococcus thermophilus LMG 18311

57.377

100

0.583
  mecA Streptococcus pneumoniae Rx1

48.571

100

0.496
  mecA Streptococcus pneumoniae D39

48.571

100

0.496
  mecA Streptococcus pneumoniae R6

48.571

100

0.496
  mecA Streptococcus pneumoniae TIGR4

48.571

100

0.496

Multiple sequence alignment