Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   QML77_RS02190 Genome accession   NZ_OX346407
Coordinates   404942..406189 (-) Length   415 a.a.
NCBI ID   WP_047242863.1    Uniprot ID   A0A1Y4QZA2
Organism   Enterococcus cecorum isolate CIRMBP-1274     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 399942..411189
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QML77_RS02155 (CIRMBP1274_00427) - 399957..400268 (+) 312 WP_016251466.1 thioredoxin family protein -
  QML77_RS02160 (CIRMBP1274_00428) - 400291..400734 (+) 444 WP_113785146.1 universal stress protein -
  QML77_RS02165 (CIRMBP1274_00429) - 400779..401381 (+) 603 WP_281957016.1 CadD family cadmium resistance transporter -
  QML77_RS02170 (CIRMBP1274_00430) ytpR 401460..402071 (+) 612 WP_281957017.1 YtpR family tRNA-binding protein -
  QML77_RS02175 (CIRMBP1274_00431) - 402137..402307 (-) 171 WP_016251470.1 hypothetical protein -
  QML77_RS02180 (CIRMBP1274_00432) - 402310..403539 (-) 1230 WP_281957018.1 MFS transporter -
  QML77_RS02185 (CIRMBP1274_00433) - 403908..404564 (+) 657 WP_047242864.1 Crp/Fnr family transcriptional regulator -
  QML77_RS02190 (CIRMBP1274_00434) htrA 404942..406189 (-) 1248 WP_047242863.1 trypsin-like peptidase domain-containing protein Regulator
  QML77_RS02195 (CIRMBP1274_00435) rlmH 406646..407125 (+) 480 WP_016251475.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  QML77_RS02200 (CIRMBP1274_00436) - 407133..407831 (+) 699 WP_016251476.1 hypothetical protein -
  QML77_RS02205 (CIRMBP1274_00437) - 407979..409157 (+) 1179 WP_047242862.1 MalY/PatB family protein -
  QML77_RS02210 (CIRMBP1274_00438) - 409184..410284 (+) 1101 WP_281957019.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
  QML77_RS02215 (CIRMBP1274_00439) - 410287..411036 (+) 750 WP_281957020.1 NADPH-dependent oxidoreductase -

Sequence

Protein


Download         Length: 415 a.a.        Molecular weight: 43061.03 Da        Isoelectric Point: 5.2387

>NTDB_id=1155148 QML77_RS02190 WP_047242863.1 404942..406189(-) (htrA) [Enterococcus cecorum isolate CIRMBP-1274]
MSRRKNSNTIMKRFGIGICSGVIGGALAFGGLYAVTGMNNATSSTGIQSAQTATKVKNVKYNVESDVTKAVSKVQGAVVS
IINLQNQNAQGTGSLEDFFGAQQGNSSSQNSGTLETASEGSGVIYKKEGKHAYIVTNNHVVEGQNALQVLLADGTKVDAE
LVGTDSYTDLAVIKIASDKVSTVATFGDSDSLKVGEPAIAIGSPLGTDYANSVTEGIISSLNRQVVSENDSGQEVNINAI
QTDAAINPGNSGGPLINIAGQVIGINSSKIATTSTSSSGVSVEGMGFAIPSNDVVNIINQLEQSGKVTRPALGVRTVDLN
ALSDQQKTNILKVPASLNEGVVLAQVNSATPAEKAGLKQYDVITEIDGEKVNDGTALRAALYKKQVGDSIKVTYYRGNDK
KTTTVHLTVDQSINE

Nucleotide


Download         Length: 1248 bp        

>NTDB_id=1155148 QML77_RS02190 WP_047242863.1 404942..406189(-) (htrA) [Enterococcus cecorum isolate CIRMBP-1274]
ATGAGTAGAAGAAAAAATTCAAATACAATTATGAAAAGATTTGGTATTGGCATTTGTAGCGGTGTGATTGGTGGTGCCCT
TGCTTTTGGTGGCTTGTATGCAGTCACAGGTATGAATAATGCGACTAGCTCAACAGGTATTCAAAGTGCCCAAACCGCAA
CTAAAGTTAAAAATGTGAAATATAATGTAGAAAGCGATGTTACAAAAGCGGTCTCTAAAGTACAAGGCGCAGTCGTTTCC
ATCATTAATTTACAAAATCAAAACGCACAAGGCACGGGCAGCTTAGAAGATTTCTTTGGTGCCCAACAAGGAAATAGTAG
CAGTCAAAATAGCGGTACTTTGGAAACAGCCAGTGAAGGTAGTGGTGTCATTTATAAAAAAGAAGGTAAACATGCCTATA
TCGTGACAAATAATCACGTGGTTGAAGGTCAAAATGCATTACAAGTCTTACTAGCAGACGGTACCAAAGTCGATGCTGAA
TTAGTTGGTACGGACAGCTATACTGACTTAGCGGTAATCAAGATTGCTAGCGATAAAGTTTCAACGGTTGCTACTTTTGG
AGATTCAGATAGTCTAAAAGTTGGTGAACCTGCCATCGCCATCGGATCACCATTAGGAACTGATTATGCCAACTCAGTGA
CTGAAGGAATTATTTCTTCTTTAAATCGTCAAGTCGTGAGTGAAAATGATTCCGGTCAAGAAGTCAATATCAATGCCATC
CAAACTGATGCAGCGATTAACCCTGGTAACTCTGGTGGTCCATTAATTAATATCGCCGGTCAAGTTATCGGAATTAACTC
AAGTAAAATTGCTACCACTTCAACCTCAAGCTCTGGTGTAAGTGTTGAAGGTATGGGCTTTGCAATTCCAAGTAATGATG
TCGTCAATATTATTAACCAACTAGAACAAAGTGGGAAAGTGACTCGTCCTGCTTTAGGGGTTAGAACGGTTGATTTGAAT
GCTTTATCTGATCAACAAAAAACAAACATCTTAAAAGTACCTGCCTCATTAAATGAAGGTGTCGTGCTTGCTCAAGTCAA
TAGTGCAACGCCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTTATTACTGAAATTGATGGCGAAAAGGTCAACGATG
GCACTGCTTTAAGAGCGGCTCTTTATAAAAAACAAGTCGGTGACAGCATTAAAGTGACTTACTATCGTGGCAATGACAAA
AAGACAACCACCGTACACCTTACCGTCGACCAATCAATTAATGAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(120-265)

PDZ domain (PDZ_2)

(310-407)

Peptidase family M50 (Peptidase_M50)

(251-410)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1Y4QZA2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

56.461

85.783

0.484
  htrA Streptococcus gordonii str. Challis substr. CH1

49.14

98.072

0.482
  htrA Streptococcus pneumoniae R6

48.529

98.313

0.477
  htrA Streptococcus pneumoniae TIGR4

48.529

98.313

0.477
  htrA Streptococcus pneumoniae D39

48.529

98.313

0.477
  htrA Streptococcus pneumoniae Rx1

48.529

98.313

0.477
  htrA Streptococcus mitis NCTC 12261

50.131

91.807

0.46

Multiple sequence alignment