Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   QML67_RS01925 Genome accession   NZ_OX346401
Coordinates   373448..374695 (-) Length   415 a.a.
NCBI ID   WP_047242863.1    Uniprot ID   A0A1Y4QZA2
Organism   Enterococcus cecorum isolate CIRMBP-1246     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 368448..379695
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QML67_RS01890 (CIRMBP1246_00372) - 368731..369042 (+) 312 WP_016251466.1 thioredoxin family protein -
  QML67_RS01895 (CIRMBP1246_00373) - 369065..369508 (+) 444 WP_047242913.1 universal stress protein -
  QML67_RS01900 (CIRMBP1246_00374) - 369553..370155 (+) 603 WP_080961615.1 CadD family cadmium resistance transporter -
  QML67_RS01905 (CIRMBP1246_00375) ytpR 370234..370845 (+) 612 WP_047242912.1 YtpR family tRNA-binding protein -
  QML67_RS01910 (CIRMBP1246_00376) - 370914..371084 (-) 171 WP_016251470.1 hypothetical protein -
  QML67_RS01915 (CIRMBP1246_00377) - 371087..372316 (-) 1230 WP_047242911.1 MFS transporter -
  QML67_RS01920 (CIRMBP1246_00378) - 372685..373341 (+) 657 WP_047242864.1 Crp/Fnr family transcriptional regulator -
  QML67_RS01925 (CIRMBP1246_00379) htrA 373448..374695 (-) 1248 WP_047242863.1 trypsin-like peptidase domain-containing protein Regulator
  QML67_RS01930 (CIRMBP1246_00380) rlmH 375152..375631 (+) 480 WP_016251475.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  QML67_RS01935 (CIRMBP1246_00381) - 375639..376337 (+) 699 WP_016251476.1 hypothetical protein -
  QML67_RS01940 (CIRMBP1246_00382) - 376485..377663 (+) 1179 WP_047242862.1 MalY/PatB family protein -
  QML67_RS01945 (CIRMBP1246_00383) - 377690..378790 (+) 1101 WP_047242861.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
  QML67_RS01950 (CIRMBP1246_00384) - 378793..379542 (+) 750 WP_047242860.1 NADPH-dependent oxidoreductase -

Sequence

Protein


Download         Length: 415 a.a.        Molecular weight: 43061.03 Da        Isoelectric Point: 5.2387

>NTDB_id=1154896 QML67_RS01925 WP_047242863.1 373448..374695(-) (htrA) [Enterococcus cecorum isolate CIRMBP-1246]
MSRRKNSNTIMKRFGIGICSGVIGGALAFGGLYAVTGMNNATSSTGIQSAQTATKVKNVKYNVESDVTKAVSKVQGAVVS
IINLQNQNAQGTGSLEDFFGAQQGNSSSQNSGTLETASEGSGVIYKKEGKHAYIVTNNHVVEGQNALQVLLADGTKVDAE
LVGTDSYTDLAVIKIASDKVSTVATFGDSDSLKVGEPAIAIGSPLGTDYANSVTEGIISSLNRQVVSENDSGQEVNINAI
QTDAAINPGNSGGPLINIAGQVIGINSSKIATTSTSSSGVSVEGMGFAIPSNDVVNIINQLEQSGKVTRPALGVRTVDLN
ALSDQQKTNILKVPASLNEGVVLAQVNSATPAEKAGLKQYDVITEIDGEKVNDGTALRAALYKKQVGDSIKVTYYRGNDK
KTTTVHLTVDQSINE

Nucleotide


Download         Length: 1248 bp        

>NTDB_id=1154896 QML67_RS01925 WP_047242863.1 373448..374695(-) (htrA) [Enterococcus cecorum isolate CIRMBP-1246]
ATGAGTAGAAGAAAAAATTCAAATACAATTATGAAAAGATTTGGTATCGGCATTTGTAGCGGTGTGATTGGTGGTGCCCT
TGCTTTTGGTGGCTTGTATGCAGTCACAGGTATGAATAATGCGACTAGCTCAACAGGTATTCAAAGTGCCCAAACCGCAA
CTAAAGTTAAAAATGTGAAATATAATGTAGAAAGCGATGTTACAAAAGCGGTCTCTAAAGTACAAGGCGCAGTCGTTTCC
ATCATTAATTTACAAAATCAAAACGCACAAGGCACGGGCAGCTTAGAAGATTTCTTTGGTGCCCAACAAGGAAATAGTAG
CAGTCAAAATAGCGGTACTTTGGAAACAGCCAGTGAAGGTAGTGGTGTCATTTATAAAAAAGAAGGTAAACATGCTTATA
TCGTGACAAATAATCACGTGGTTGAAGGTCAAAATGCATTACAAGTCTTACTAGCAGACGGTACCAAAGTCGATGCTGAA
TTAGTTGGTACGGACAGCTATACTGACTTAGCGGTAATCAAGATTGCTAGCGATAAAGTTTCAACGGTTGCTACTTTTGG
AGATTCAGATAGTCTAAAAGTTGGTGAACCTGCCATCGCCATCGGATCACCATTAGGAACTGATTATGCCAACTCAGTGA
CTGAAGGAATTATTTCTTCTTTAAATCGTCAAGTCGTGAGTGAAAATGATTCCGGTCAAGAAGTCAATATCAATGCCATC
CAAACTGATGCAGCGATTAACCCTGGTAACTCTGGTGGTCCATTAATTAATATCGCCGGTCAAGTTATCGGAATTAACTC
AAGTAAAATTGCTACCACTTCAACCTCAAGCTCTGGTGTAAGTGTTGAAGGTATGGGCTTTGCAATTCCAAGTAATGATG
TCGTCAATATTATTAACCAACTAGAACAAAGTGGGAAAGTGACTCGTCCTGCTTTAGGGGTTAGAACGGTTGATTTGAAT
GCTTTATCTGATCAACAAAAAACAAACATCTTAAAAGTACCTGCCTCATTAAATGAAGGTGTCGTGCTTGCTCAAGTCAA
TAGTGCAACGCCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTTATTACTGAAATTGATGGCGAAAAGGTCAACGATG
GCACTGCTTTAAGAGCGGCTCTTTATAAAAAACAAGTCGGTGACAGCATTAAAGTGACTTACTATCGTGGCAATGACAAA
AAGACAACCACCGTACACCTTACCGTCGACCAATCAATTAATGAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(120-265)

PDZ domain (PDZ_2)

(310-407)

Peptidase family M50 (Peptidase_M50)

(251-410)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1Y4QZA2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

56.461

85.783

0.484
  htrA Streptococcus gordonii str. Challis substr. CH1

49.14

98.072

0.482
  htrA Streptococcus pneumoniae R6

48.529

98.313

0.477
  htrA Streptococcus pneumoniae TIGR4

48.529

98.313

0.477
  htrA Streptococcus pneumoniae D39

48.529

98.313

0.477
  htrA Streptococcus pneumoniae Rx1

48.529

98.313

0.477
  htrA Streptococcus mitis NCTC 12261

50.131

91.807

0.46

Multiple sequence alignment