Detailed information NTG1147468

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: CKV85_RS01730
• Genome accession: NZ_LT906454
• Coordinates: 349888..350655 (+)
• Length: 255 a.a.
• NCBI ID: WP_017768996.1
• Uniprot ID: A0A239WKU3
• Organism: Streptococcus acidominimus strain NCTC11291
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 344888..355655

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CKV85_RS01705 (SAMEA4504048_00358)	-	344981..345874 (+)	894	WP_095121670.1	SPFH domain-containing protein	-
CKV85_RS01710 (SAMEA4504048_00359)	-	346024..346143 (-)	120	WP_017768991.1	putative metal homeostasis protein	-
CKV85_RS01715 (SAMEA4504048_00360)	-	346413..347153 (-)	741	WP_017768992.1	amino acid ABC transporter ATP-binding protein	-
CKV85_RS01720 (SAMEA4504048_00361)	-	347146..348714 (-)	1569	WP_095121673.1	ABC transporter substrate-binding protein/permease	-
CKV85_RS01725 (SAMEA4504048_00362)	-	348896..349735 (+)	840	WP_095121675.1	undecaprenyl-diphosphate phosphatase	-
CKV85_RS01730 (SAMEA4504048_00363)	mecA	349888..350655 (+)	768	WP_017768996.1	adaptor protein MecA	Regulator
CKV85_RS01735 (SAMEA4504048_00364)	-	350655..351821 (+)	1167	WP_017768997.1	glycosyltransferase family 4 protein	-
CKV85_RS01740 (SAMEA4504048_00365)	sufC	351903..352676 (+)	774	WP_095121677.1	Fe-S cluster assembly ATPase SufC	-
CKV85_RS01745 (SAMEA4504048_00366)	sufD	352686..353948 (+)	1263	WP_095121679.1	Fe-S cluster assembly protein SufD	-
CKV85_RS01750 (SAMEA4504048_00367)	-	354019..355245 (+)	1227	WP_095121681.1	cysteine desulfurase	-

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 29355.27 Da
• Isoelectric Point: 4.1972

>NTDB_id=1147468 CKV85_RS01730 WP_017768996.1 349888..350655(+) (mecA) [Streptococcus acidominimus strain NCTC11291]
MEMKQISETTLKIIISMEDLEERGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPKKDRLDVFVTKSEI
DKDLNFEDLADLGDVSQMSPDEFFKTLEKSMLEKGDVDAHKKLKQMEDMVESAMTDAMAASEQTSDPVSEEDDALDTPEY
THYVLIFSTVKEVVRFSKAIDFEVEASELYKLSGQYYMTVLVGLEDKPAYYADLIHSRLLEYSREGLKTRAYLQEHGVRL
LEGTAIQILEGIRVN

Nucleotide

• Length: 768 bp

>NTDB_id=1147468 CKV85_RS01730 WP_017768996.1 349888..350655(+) (mecA) [Streptococcus acidominimus strain NCTC11291]
ATGGAAATGAAACAAATTAGCGAAACGACGCTAAAAATTATAATTAGTATGGAAGACTTAGAAGAACGGGGAATGGAGTT
GAAAGATTTCTTGATTCCACAAGAAAAAACGGAAGAGTTTTTTTATACCGTTATGGATGAGTTGGATTTGCCCGATAATT
TTAAAAACAGTGGCATGCTCAGTTTTAGGGTGACGCCCAAAAAGGATCGCTTAGATGTTTTTGTGACAAAGTCTGAGATT
GATAAAGACCTTAATTTTGAAGATTTGGCGGATCTTGGCGATGTTTCGCAAATGTCACCGGATGAATTTTTTAAGACATT
GGAAAAATCGATGTTGGAGAAAGGGGATGTAGATGCCCATAAAAAACTAAAACAAATGGAAGATATGGTTGAGTCAGCAA
TGACAGATGCTATGGCAGCATCTGAACAAACCTCTGATCCCGTATCCGAAGAGGACGATGCTTTGGATACACCGGAGTAT
ACTCACTATGTTCTGATATTTTCAACAGTTAAAGAGGTTGTTAGATTTTCAAAAGCGATTGATTTTGAGGTTGAAGCTTC
TGAATTGTATAAACTTTCTGGGCAGTATTATATGACAGTATTAGTTGGTCTCGAGGACAAACCTGCTTATTATGCTGACT
TGATTCATTCAAGATTGTTAGAATATAGTCGCGAAGGTTTAAAAACACGTGCTTACCTCCAAGAACATGGTGTTCGTTTA
TTGGAAGGGACTGCTATCCAAATATTAGAGGGTATTAGGGTGAACTAA

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-249)

3D structure

• AlphaFold DB: A0A239WKU3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus mutans UA159	60.714	98.824	0.6
mecA	Streptococcus thermophilus LMD-9	55.906	99.608	0.557
mecA	Streptococcus thermophilus LMG 18311	55.118	99.608	0.549
mecA	Streptococcus pneumoniae Rx1	47.471	100	0.478
mecA	Streptococcus pneumoniae D39	47.471	100	0.478
mecA	Streptococcus pneumoniae R6	47.471	100	0.478
mecA	Streptococcus pneumoniae TIGR4	47.471	100	0.478