Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   CKV83_RS09825 Genome accession   NZ_LT906439
Coordinates   2085813..2086550 (+) Length   245 a.a.
NCBI ID   WP_018373632.1    Uniprot ID   A0A239SZ06
Organism   Streptococcus merionis strain NCTC13788     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 2080813..2091550
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CKV83_RS09805 (SAMEA4412692_01958) - 2081479..2081688 (+) 210 WP_018373636.1 hypothetical protein -
  CKV83_RS09810 (SAMEA4412692_01959) - 2082186..2083307 (+) 1122 WP_018373635.1 carbohydrate kinase -
  CKV83_RS09815 (SAMEA4412692_01960) - 2083297..2084214 (+) 918 WP_018373634.1 pseudouridine-5'-phosphate glycosidase -
  CKV83_RS09820 (SAMEA4412692_01961) - 2084577..2085431 (+) 855 WP_040834618.1 undecaprenyl-diphosphate phosphatase -
  CKV83_RS09825 (SAMEA4412692_01962) mecA 2085813..2086550 (+) 738 WP_018373632.1 adaptor protein MecA Regulator
  CKV83_RS09830 (SAMEA4412692_01963) - 2086547..2087713 (+) 1167 WP_018373631.1 glycosyltransferase family 4 protein -
  CKV83_RS09835 (SAMEA4412692_01964) sufC 2087926..2088696 (+) 771 WP_018373630.1 Fe-S cluster assembly ATPase SufC -
  CKV83_RS09840 (SAMEA4412692_01965) sufD 2088739..2090001 (+) 1263 WP_018373629.1 Fe-S cluster assembly protein SufD -
  CKV83_RS09845 (SAMEA4412692_01966) - 2090005..2091240 (+) 1236 WP_018373628.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28323.04 Da        Isoelectric Point: 4.2006

>NTDB_id=1147153 CKV83_RS09825 WP_018373632.1 2085813..2086550(+) (mecA) [Streptococcus merionis strain NCTC13788]
MEVKQISESTLKITIKLDDLEARGMELSDFLIPQEKTEEFFYSILDELEMPEHFLHSGMLSFRVTPKPDKLDIFVTKSDI
DQELDFQDLAEMANVEDISHLSPDDFFSTLEKTLKSKSSADSKAVAALELLESQMAQEEQAVEDEEMSRYVYFTLRFKDL
SEAIGFAKSVDYPVDTSELYKYNGAYYMTILLDFLNETPRYASFMHARIMEHAEDTGVTRPYLQEHGYVMLQVDAIERLK
KVELV

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1147153 CKV83_RS09825 WP_018373632.1 2085813..2086550(+) (mecA) [Streptococcus merionis strain NCTC13788]
ATGGAAGTTAAGCAAATTAGTGAATCAACCTTGAAAATCACGATAAAATTAGACGATTTAGAAGCACGAGGAATGGAATT
GTCTGATTTTCTGATTCCTCAGGAGAAAACGGAAGAATTTTTCTACAGTATTTTGGATGAATTAGAGATGCCTGAGCATT
TTTTACATTCTGGAATGCTGTCTTTTCGGGTGACACCGAAACCGGATAAACTCGATATTTTTGTGACCAAGTCAGACATT
GATCAGGAACTGGACTTTCAAGATTTGGCTGAGATGGCCAACGTTGAGGATATTTCCCATCTGTCGCCTGATGATTTTTT
TAGCACCTTAGAAAAAACGCTGAAGAGCAAGAGTTCTGCAGATAGCAAGGCGGTCGCAGCTCTAGAGCTTTTGGAAAGCC
AGATGGCGCAAGAAGAGCAAGCAGTAGAAGATGAAGAGATGAGCCGCTATGTCTATTTCACCCTGCGGTTTAAGGATTTG
TCAGAGGCTATTGGTTTTGCTAAGAGTGTGGATTACCCAGTGGACACATCAGAATTGTATAAGTACAACGGTGCCTACTA
TATGACCATTTTGCTGGACTTTTTGAACGAGACACCTCGTTATGCTAGTTTTATGCATGCGCGAATTATGGAGCATGCAG
AGGACACTGGTGTGACACGTCCCTACCTGCAGGAACATGGCTATGTCATGTTACAGGTTGATGCTATTGAGCGTCTCAAG
AAGGTGGAACTCGTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A239SZ06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae R6

51.639

99.592

0.514
  mecA Streptococcus pneumoniae Rx1

51.639

99.592

0.514
  mecA Streptococcus pneumoniae D39

51.639

99.592

0.514
  mecA Streptococcus pneumoniae TIGR4

51.639

99.592

0.514
  mecA Streptococcus mutans UA159

51.029

99.184

0.506
  mecA Streptococcus thermophilus LMD-9

45.749

100

0.461
  mecA Streptococcus thermophilus LMG 18311

45.344

100

0.457

Multiple sequence alignment