Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   CKV83_RS00985 Genome accession   NZ_LT906439
Coordinates   214632..216461 (+) Length   609 a.a.
NCBI ID   WP_018373097.1    Uniprot ID   -
Organism   Streptococcus merionis strain NCTC13788     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 209632..221461
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CKV83_RS00970 (SAMEA4412692_00198) fmt 211632..212561 (+) 930 WP_018373094.1 methionyl-tRNA formyltransferase -
  CKV83_RS00975 (SAMEA4412692_00199) rsmB 212554..213870 (+) 1317 WP_026216890.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  CKV83_RS00980 (SAMEA4412692_00200) - 213895..214632 (+) 738 WP_018373096.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  CKV83_RS00985 (SAMEA4412692_00201) pknB 214632..216461 (+) 1830 WP_018373097.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  CKV83_RS00990 (SAMEA4412692_00202) liaF 216718..217419 (+) 702 WP_018373098.1 cell wall-active antibiotics response protein LiaF -
  CKV83_RS00995 (SAMEA4412692_00203) - 217416..218426 (+) 1011 WP_018373099.1 sensor histidine kinase -
  CKV83_RS01000 (SAMEA4412692_00204) - 218413..219051 (+) 639 WP_018373100.1 response regulator transcription factor -
  CKV83_RS01005 (SAMEA4412692_00205) - 219218..220543 (-) 1326 WP_026216891.1 PTS sugar transporter subunit IIC -
  CKV83_RS01010 (SAMEA4412692_00206) - 220543..220872 (-) 330 WP_018373102.1 PTS sugar transporter subunit IIB -
  CKV83_RS01015 (SAMEA4412692_00207) - 220889..221215 (-) 327 WP_018373103.1 PTS lactose/cellobiose transporter subunit IIA -

Sequence

Protein


Download         Length: 609 a.a.        Molecular weight: 67173.98 Da        Isoelectric Point: 4.8747

>NTDB_id=1147120 CKV83_RS00985 WP_018373097.1 214632..216461(+) (pknB) [Streptococcus merionis strain NCTC13788]
MIQIGKIFAGRYKVIEQIGRGGMADVYLARDLILDGEEVAVKVLRTNYQTDQVAIQRFQREARAMADLDHPNIVRISDIG
EEDGQQYLAMEYVDALDLKKYIQDKAPFSNEEAVRVMAQILLAMRLAHQQGIVHRDIKPQNVLLTKEGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIVLYEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENPKVP
QALENVVIKATAKKLSDRYQTVEDMYTDLVTCLSPRHQLDRKLIFSDNKVDSKVLPKVTPPPQEVSRQEELRVPEEEYSH
PYESNDDYKPKRRMRMRFKVLFGAIFLTLLALVAIFLTSPTTVIVPDVAGQTLEAAQQTLAKAGLRVDQVRKESSDTVPE
GTVIATDPESGTSKRKHSSVKIIVSKGDRDFTLEDYVGQAYSDVVNALTERGVDESYIKLEEVENGDHQVGTIIEQSLEA
GTLYDLDKPKRITFKVAKAQSTVMMPNLTGLTYKQAVNVLVGLGIKANQITTVPEAISATAVVESQSIYAFTEIYPETVN
IVLHFAAEESTSSSSTNASSTRPTRSSSSTEPSSDTDTDASTDDDNAGE

Nucleotide


Download         Length: 1830 bp        

>NTDB_id=1147120 CKV83_RS00985 WP_018373097.1 214632..216461(+) (pknB) [Streptococcus merionis strain NCTC13788]
ATGATTCAAATCGGGAAAATATTCGCTGGACGGTACAAGGTTATTGAGCAAATTGGCCGAGGTGGAATGGCGGATGTTTA
TCTGGCAAGAGACCTCATTCTAGACGGCGAGGAAGTTGCAGTCAAGGTCTTAAGAACCAATTACCAGACAGATCAGGTAG
CGATTCAACGTTTCCAGCGTGAAGCGCGAGCCATGGCTGATCTGGATCATCCAAATATCGTCCGCATTAGCGACATCGGA
GAGGAAGATGGCCAGCAGTACCTAGCCATGGAATATGTTGATGCCTTAGACCTTAAAAAATATATTCAAGATAAGGCACC
TTTTTCAAATGAGGAAGCCGTTCGTGTTATGGCACAGATCCTCTTGGCCATGCGGCTTGCTCATCAGCAAGGTATTGTCC
ATCGCGATATCAAGCCACAAAATGTCCTTTTGACAAAAGAAGGCACCGCTAAGGTGACCGATTTTGGGATTGCAGTCGCT
TTCGCAGAAACCAGCCTAACTCAAACCAATTCCATGCTAGGCTCTGTTCATTACCTGTCACCTGAACAGGCGCGTGGTTC
AAAAGCCACAGTCCAAAGTGACATTTATGCCATGGGGATTGTTCTTTACGAAATGCTGACGGGCCATATTCCTTATGACG
GGGATTCGGCTGTTACCATTGCACTTCAGCATTTTCAGAAACCTCTGCCATCAATCATTGCAGAAAATCCAAAAGTCCCT
CAAGCTCTTGAAAATGTTGTCATCAAAGCGACAGCAAAGAAGTTATCTGACCGTTATCAAACTGTAGAGGACATGTATAC
AGACCTGGTGACTTGCTTGTCGCCGAGGCATCAACTAGATCGTAAACTAATCTTTTCAGACAATAAAGTAGACAGTAAAG
TATTGCCAAAAGTGACACCTCCTCCTCAAGAGGTTTCGCGCCAAGAAGAGTTGCGTGTGCCTGAGGAAGAATACTCGCAT
CCCTATGAATCCAATGACGACTACAAACCTAAACGTCGGATGCGTATGCGGTTTAAAGTGCTTTTTGGGGCTATTTTCTT
GACACTTTTAGCTTTAGTGGCAATTTTCCTGACCAGTCCTACAACAGTGATAGTTCCAGATGTTGCAGGACAAACGCTGG
AAGCAGCACAACAAACGCTTGCTAAGGCTGGCTTGAGAGTTGATCAAGTGCGTAAGGAATCTAGCGATACCGTCCCTGAA
GGAACAGTTATCGCAACTGATCCTGAGAGTGGAACCAGCAAGCGCAAGCATTCTTCTGTCAAGATTATTGTATCCAAAGG
AGATCGTGATTTTACTTTGGAAGATTATGTCGGTCAAGCCTATAGCGATGTGGTCAATGCCTTAACTGAGCGAGGTGTGG
ATGAATCCTATATCAAACTGGAAGAGGTTGAAAACGGAGACCATCAGGTCGGAACCATTATTGAACAGTCGCTTGAAGCA
GGGACTTTGTATGATTTAGATAAACCTAAGAGAATCACTTTTAAGGTTGCTAAAGCGCAGTCTACTGTCATGATGCCTAA
TTTGACTGGCTTAACCTATAAACAGGCCGTCAACGTTCTGGTTGGATTGGGGATTAAAGCCAATCAAATCACCACTGTTC
CAGAAGCAATTAGTGCCACAGCAGTTGTAGAATCCCAGAGTATCTACGCTTTCACAGAAATTTATCCAGAAACGGTTAAT
ATCGTTCTTCATTTTGCTGCAGAGGAATCAACATCGTCGTCTTCTACCAATGCTTCCTCAACAAGACCGACAAGATCATC
TAGCAGCACTGAACCGTCATCCGATACCGATACGGATGCGTCAACTGATGACGATAATGCTGGTGAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(503-563)

PASTA domain (PASTA)

(432-496)

PASTA domain (PASTA)

(363-426)

Protein kinase domain (Pkinase)

(12-233)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

59.926

88.506

0.53
  stkP Streptococcus pneumoniae TIGR4

60.728

85.714

0.521
  stkP Streptococcus pneumoniae D39

60.345

85.714

0.517
  stkP Streptococcus pneumoniae R6

60.345

85.714

0.517
  stkP Streptococcus pneumoniae Rx1

60.153

85.714

0.516
  stkP/pknB Streptococcus salivarius strain HSISS4

56.934

89.984

0.512

Multiple sequence alignment