Detailed information NTG1143041

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: STN4L_RS06305
• Genome accession: NZ_LS974444
• Coordinates: 1210603..1211352 (-)
• Length: 249 a.a.
• NCBI ID: WP_011680667.1
• Uniprot ID: Q03MN5
• Organism: Streptococcus thermophilus strain N4L
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1205603..1216352

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STN4L_RS06285 (STN4L_01472)	-	1205926..1207158 (-)	1233	WP_113870450.1	cysteine desulfurase	-
STN4L_RS06290 (STN4L_01473)	sufD	1207212..1208474 (-)	1263	WP_014621089.1	Fe-S cluster assembly protein SufD	-
STN4L_RS06295 (STN4L_01474)	sufC	1208511..1209281 (-)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
STN4L_RS06300 (STN4L_01475)	-	1209442..1210599 (-)	1158	WP_014621088.1	glycosyltransferase family 4 protein	-
STN4L_RS06305 (STN4L_01476)	mecA	1210603..1211352 (-)	750	WP_011680667.1	adaptor protein MecA	Regulator
STN4L_RS06310	-	1211636..1211926 (+)	291	WP_223899616.1	DUF3021 family protein	-
STN4L_RS06315 (STN4L_01478)	-	1211978..1212832 (-)	855	WP_011680666.1	undecaprenyl-diphosphate phosphatase	-
STN4L_RS06320 (STN4L_01479)	-	1213035..1214585 (+)	1551	WP_011680665.1	ABC transporter substrate-binding protein/permease	-
STN4L_RS06325 (STN4L_01480)	-	1214585..1215325 (+)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
STN4L_RS06330 (STN4L_01481)	-	1215412..1215519 (-)	108	WP_081247985.1	LPXTG cell wall anchor domain-containing protein	-
STN4L_RS10065 (STN4L_01482)	-	1215606..1215776 (-)	171	WP_011680664.1	hypothetical protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29174.68 Da
• Isoelectric Point: 4.0481

>NTDB_id=1143041 STN4L_RS06305 WP_011680667.1 1210603..1211352(-) (mecA) [Streptococcus thermophilus strain N4L]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide

• Length: 750 bp

>NTDB_id=1143041 STN4L_RS06305 WP_011680667.1 1210603..1211352(-) (mecA) [Streptococcus thermophilus strain N4L]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-242)

3D structure

• AlphaFold DB: Q03MN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus thermophilus LMD-9	100	100	1
mecA	Streptococcus thermophilus LMG 18311	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.787	97.992	0.566
mecA	Streptococcus pneumoniae Rx1	46.586	100	0.466
mecA	Streptococcus pneumoniae D39	46.586	100	0.466
mecA	Streptococcus pneumoniae R6	46.586	100	0.466
mecA	Streptococcus pneumoniae TIGR4	46.586	100	0.466