Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQN71_RS09250 Genome accession   NZ_LS483471
Coordinates   1765653..1766399 (-) Length   248 a.a.
NCBI ID   WP_015605704.1    Uniprot ID   A0A512ADZ5
Organism   Streptococcus cristatus strain NCTC13807     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1760653..1771399
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN71_RS09230 (NCTC13807_01762) - 1761058..1762290 (-) 1233 WP_015605700.1 cysteine desulfurase -
  DQN71_RS09235 (NCTC13807_01763) sufD 1762331..1763593 (-) 1263 WP_015605701.1 Fe-S cluster assembly protein SufD -
  DQN71_RS09240 (NCTC13807_01764) sufC 1763635..1764405 (-) 771 WP_015605702.1 Fe-S cluster assembly ATPase SufC -
  DQN71_RS09245 (NCTC13807_01765) - 1764490..1765662 (-) 1173 WP_041826834.1 glycosyltransferase family 4 protein -
  DQN71_RS09250 (NCTC13807_01766) mecA 1765653..1766399 (-) 747 WP_015605704.1 adaptor protein MecA Regulator
  DQN71_RS09260 (NCTC13807_01767) - 1766664..1767506 (-) 843 WP_015605705.1 undecaprenyl-diphosphate phosphatase -
  DQN71_RS09265 (NCTC13807_01768) - 1767595..1769490 (-) 1896 WP_015605706.1 DUF2207 domain-containing protein -
  DQN71_RS09270 (NCTC13807_01769) - 1769621..1771186 (+) 1566 WP_015605707.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 248 a.a.        Molecular weight: 28843.36 Da        Isoelectric Point: 3.9084

>NTDB_id=1142332 DQN71_RS09250 WP_015605704.1 1765653..1766399(-) (mecA) [Streptococcus cristatus strain NCTC13807]
MEVKQINDSTIKITIQLEDLEEHGMEIADFLVPQEKTEEFFYTILDELEMPESFLDSGMLSFRVTPKPDKLDVFVTRSKI
DKNLNFEDLGNLPDLDELSQMSPDEFLKTLEKNIFEKSKDDLEAVKSLEEAEADQEDSADSSEEKEEENLDRYVYYILSF
TDLRSVVSFAKTVDYPIDLSELYKYDSAYYLTILVDLEEQPELYPAWLLAKMREFAEDTDITRAVLQEHGRLLLVTEAIQ
QLQKVECV

Nucleotide


Download         Length: 747 bp        

>NTDB_id=1142332 DQN71_RS09250 WP_015605704.1 1765653..1766399(-) (mecA) [Streptococcus cristatus strain NCTC13807]
ATGGAAGTGAAACAGATTAATGATTCGACGATTAAAATCACCATCCAATTGGAAGATTTAGAAGAACACGGCATGGAAAT
TGCAGATTTCCTAGTTCCCCAAGAAAAAACAGAAGAATTTTTCTATACAATCTTGGATGAGCTGGAAATGCCGGAAAGTT
TCTTAGATAGTGGGATGCTGAGCTTTCGGGTGACGCCTAAGCCAGACAAGCTGGATGTCTTTGTAACAAGATCCAAGATT
GATAAGAATTTGAATTTTGAAGATTTGGGCAATCTACCAGATCTGGATGAGCTCAGCCAGATGTCTCCAGATGAATTTTT
AAAGACTTTGGAAAAAAATATCTTTGAAAAGAGTAAGGATGATCTCGAGGCGGTTAAATCTTTAGAGGAAGCAGAGGCTG
ATCAGGAGGATTCTGCAGATTCTTCAGAAGAGAAGGAAGAAGAGAATCTAGACCGGTATGTCTATTATATTCTATCTTTT
ACTGACCTGCGCAGCGTAGTTTCTTTCGCCAAAACGGTTGACTATCCGATAGACCTGTCAGAACTCTATAAATATGACTC
TGCCTACTACCTGACTATTTTGGTAGATTTGGAAGAGCAACCGGAGCTCTATCCAGCTTGGTTACTGGCTAAAATGCGGG
AATTTGCTGAGGATACAGATATTACTCGTGCTGTCCTGCAAGAACACGGACGTCTGCTTTTGGTGACAGAAGCCATCCAA
CAATTGCAAAAGGTTGAATGCGTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A512ADZ5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

65.306

98.79

0.645
  mecA Streptococcus pneumoniae D39

65.306

98.79

0.645
  mecA Streptococcus pneumoniae R6

65.306

98.79

0.645
  mecA Streptococcus pneumoniae TIGR4

64.898

98.79

0.641
  mecA Streptococcus mutans UA159

50.612

98.79

0.5
  mecA Streptococcus thermophilus LMG 18311

46.245

100

0.472
  mecA Streptococcus thermophilus LMD-9

45.85

100

0.468

Multiple sequence alignment