Detailed information
Bioinformatically predicted
Overview
| Name | ciaR | Type | Regulator |
| Locus tag | DQL01_RS04225 | Genome accession | NZ_LS483451 |
| Coordinates | 782332..783006 (+) | Length | 224 a.a. |
| NCBI ID | WP_000590640.1 | Uniprot ID | D4I4V1 |
| Organism | Streptococcus pneumoniae strain 4041STDY6836166 | ||
| Function | repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 736021..785911 | 782332..783006 | within | 0 |
Gene organization within MGE regions
Location: 736021..785911
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL01_RS03955 | - | 736068..736316 (+) | 249 | WP_000462126.1 | YlbG family protein | - |
| DQL01_RS03960 | - | 736418..737578 (+) | 1161 | WP_000726146.1 | ABC transporter substrate-binding protein | - |
| DQL01_RS03965 | - | 737846..738715 (+) | 870 | WP_000941419.1 | branched-chain amino acid ABC transporter permease | - |
| DQL01_RS03970 | - | 738719..739675 (+) | 957 | WP_000662293.1 | branched-chain amino acid ABC transporter permease | - |
| DQL01_RS03975 | - | 739675..740439 (+) | 765 | WP_001186003.1 | ABC transporter ATP-binding protein | - |
| DQL01_RS03980 | - | 740439..741149 (+) | 711 | WP_000062219.1 | ABC transporter ATP-binding protein | - |
| DQL01_RS03985 | - | 741457..742113 (+) | 657 | WP_000268677.1 | CBS domain-containing protein | - |
| DQL01_RS03990 | prfB | 742221..743316 (+) | 1096 | WP_111702498.1 | peptide chain release factor 2 | - |
| DQL01_RS03995 | ftsE | 743334..744026 (+) | 693 | WP_000022268.1 | cell division ATP-binding protein FtsE | - |
| DQL01_RS04000 | ftsX | 744019..744945 (+) | 927 | WP_000625536.1 | permease-like cell division protein FtsX | - |
| DQL01_RS04005 | - | 745231..747411 (+) | 2181 | WP_078138275.1 | PTS transporter subunit IIBC | - |
| DQL01_RS04010 | - | 747463..748278 (+) | 816 | WP_000670830.1 | endonuclease/exonuclease/phosphatase family protein | - |
| DQL01_RS04015 | - | 748418..749761 (+) | 1344 | WP_050221128.1 | DEAD/DEAH box helicase | - |
| DQL01_RS04025 | metK | 750138..751328 (+) | 1191 | WP_000003935.1 | methionine adenosyltransferase | - |
| DQL01_RS04035 | - | 751881..752816 (+) | 936 | WP_000255160.1 | dihydroorotate oxidase | - |
| DQL01_RS04040 | holA | 752850..753887 (+) | 1038 | WP_111702499.1 | DNA polymerase III subunit delta | - |
| DQL01_RS04045 | sodA | 754060..754665 (+) | 606 | WP_000974746.1 | superoxide dismutase SodA | - |
| DQL01_RS04050 | - | 754821..755351 (+) | 531 | WP_001224352.1 | YutD family protein | - |
| DQL01_RS04055 | rlmN | 755372..756457 (+) | 1086 | WP_111702500.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| DQL01_RS04060 | - | 756457..756939 (+) | 483 | WP_000976708.1 | VanZ family protein | - |
| DQL01_RS04065 | - | 756941..758482 (+) | 1542 | WP_000025400.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| DQL01_RS04070 | - | 758538..759341 (-) | 804 | WP_061841802.1 | peptidylprolyl isomerase | - |
| DQL01_RS04075 | - | 759424..759654 (-) | 231 | WP_000011700.1 | hypothetical protein | - |
| DQL01_RS04085 | - | 760127..760342 (-) | 216 | WP_061841801.1 | hypothetical protein | - |
| DQL01_RS04090 | rpsP | 760512..760784 (+) | 273 | WP_000268761.1 | 30S ribosomal protein S16 | - |
| DQL01_RS04095 | kphA | 760804..761043 (+) | 240 | WP_000379621.1 | RNA-binding protein KphA | - |
| DQL01_RS04100 | - | 761204..761516 (+) | 313 | Protein_780 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| DQL01_RS04105 | - | 761620..762393 (+) | 774 | WP_061366279.1 | alpha/beta hydrolase | - |
| DQL01_RS04110 | rimM | 762439..762957 (+) | 519 | WP_001105899.1 | ribosome maturation factor RimM | - |
| DQL01_RS04115 | trmD | 762947..763666 (+) | 720 | WP_061366280.1 | tRNA (guanosine(37)-N1)-methyltransferase TrmD | - |
| DQL01_RS04120 | - | 763678..764016 (+) | 339 | WP_001196049.1 | ATP cone domain-containing protein | - |
| DQL01_RS04125 | - | 764046..764366 (-) | 321 | WP_001216099.1 | hypothetical protein | - |
| DQL01_RS04130 | - | 764464..764679 (+) | 216 | WP_000807422.1 | YdbC family protein | - |
| DQL01_RS12350 | - | 764676..764822 (-) | 147 | WP_001809980.1 | hypothetical protein | - |
| DQL01_RS04140 | - | 764884..765420 (-) | 537 | WP_000709037.1 | biotin transporter BioY | - |
| DQL01_RS04145 | gor | 765617..766963 (-) | 1347 | WP_001209571.1 | glutathione-disulfide reductase | - |
| DQL01_RS04150 | - | 767228..768427 (+) | 1200 | WP_061366281.1 | efflux RND transporter periplasmic adaptor subunit | - |
| DQL01_RS04155 | - | 768411..769112 (+) | 702 | WP_000811482.1 | ABC transporter ATP-binding protein | - |
| DQL01_RS04160 | - | 769114..770373 (+) | 1260 | WP_001180425.1 | ABC transporter permease | - |
| DQL01_RS04165 | metG | 770497..772494 (+) | 1998 | WP_061366282.1 | methionine--tRNA ligase | - |
| DQL01_RS12355 | - | 772544..772717 (+) | 174 | WP_223842241.1 | hypothetical protein | - |
| DQL01_RS04170 | - | 772792..774189 (+) | 1398 | Protein_795 | ISNCY-like element IS1202 family transposase | - |
| DQL01_RS04180 | - | 774618..774938 (+) | 321 | WP_000665420.1 | PadR family transcriptional regulator | - |
| DQL01_RS04185 | - | 774942..775757 (+) | 816 | WP_000738406.1 | membrane protein | - |
| DQL01_RS04190 | - | 775832..776758 (+) | 927 | WP_001269466.1 | aldo/keto reductase | - |
| DQL01_RS04195 | - | 776854..777090 (+) | 237 | WP_000141921.1 | DUF2829 domain-containing protein | - |
| DQL01_RS04200 | - | 777083..777781 (+) | 699 | WP_000167119.1 | 3-oxoacyl-ACP reductase | - |
| DQL01_RS04205 | - | 777792..778292 (+) | 501 | WP_000403347.1 | NUDIX hydrolase | - |
| DQL01_RS04210 | - | 778270..779139 (+) | 870 | WP_000795799.1 | putative PEP-binding protein | - |
| DQL01_RS04215 | - | 779114..779554 (+) | 441 | WP_001820631.1 | ASCH domain-containing protein | - |
| DQL01_RS04220 | - | 779677..782223 (+) | 2547 | WP_111702501.1 | M1 family metallopeptidase | - |
| DQL01_RS04225 | ciaR | 782332..783006 (+) | 675 | WP_000590640.1 | two-component system response regulator CiaR | Regulator |
| DQL01_RS04230 | ciaH | 782996..784330 (+) | 1335 | WP_000491790.1 | two-component system sensor histidine kinase CiaH | Regulator |
| DQL01_RS04235 | - | 784364..784651 (-) | 288 | WP_001145225.1 | DUF3270 domain-containing protein | - |
| DQL01_RS04240 | - | 784791..785720 (+) | 930 | WP_050205469.1 | peptidase U32 family protein | - |
Sequence
Protein
Download Length: 224 a.a. Molecular weight: 25466.29 Da Isoelectric Point: 4.3283
>NTDB_id=1142049 DQL01_RS04225 WP_000590640.1 782332..783006(+) (ciaR) [Streptococcus pneumoniae strain 4041STDY6836166]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ
Nucleotide
Download Length: 675 bp
>NTDB_id=1142049 DQL01_RS04225 WP_000590640.1 782332..783006(+) (ciaR) [Streptococcus pneumoniae strain 4041STDY6836166]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGTGTCTATGACTTGATTTTGCTCGATTTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACTCCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGACTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACTTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGTGTCTATGACTTGATTTTGCTCGATTTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACTCCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGACTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACTTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ciaR | Streptococcus pneumoniae Rx1 |
100 |
100 |
1 |
| ciaR | Streptococcus pneumoniae D39 |
100 |
100 |
1 |
| ciaR | Streptococcus pneumoniae R6 |
100 |
100 |
1 |
| ciaR | Streptococcus pneumoniae TIGR4 |
100 |
100 |
1 |
| ciaR | Streptococcus mutans UA159 |
88.393 |
100 |
0.884 |
| covR | Lactococcus lactis subsp. lactis strain DGCC12653 |
36.726 |
100 |
0.371 |
| vicR | Streptococcus mutans UA159 |
35.622 |
100 |
0.371 |