Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQL20_RS02205 Genome accession   NZ_LS483444
Coordinates   386521..387267 (+) Length   248 a.a.
NCBI ID   WP_006594967.1    Uniprot ID   E7S7I0
Organism   Streptococcus australis strain NCTC13166     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 381521..392267
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL20_RS02190 (NCTC11371_00432) - 381770..383332 (-) 1563 WP_006594970.1 ABC transporter substrate-binding protein/permease -
  DQL20_RS02195 (NCTC11371_00433) - 383453..385360 (+) 1908 WP_006594969.1 DUF2207 domain-containing protein -
  DQL20_RS02200 (NCTC11371_00434) - 385520..386356 (+) 837 WP_006594968.1 undecaprenyl-diphosphate phosphatase -
  DQL20_RS02205 (NCTC11371_00435) mecA 386521..387267 (+) 747 WP_006594967.1 adaptor protein MecA Regulator
  DQL20_RS02210 (NCTC11371_00436) - 387264..388421 (+) 1158 WP_006594966.1 glycosyltransferase family 4 protein -
  DQL20_RS02215 (NCTC11371_00437) sufC 388508..389278 (+) 771 WP_006594965.1 Fe-S cluster assembly ATPase SufC -
  DQL20_RS02220 (NCTC11371_00438) sufD 389320..390582 (+) 1263 WP_006594964.1 Fe-S cluster assembly protein SufD -
  DQL20_RS02225 (NCTC11371_00439) - 390585..391811 (+) 1227 WP_006594963.1 cysteine desulfurase -
  DQL20_RS02230 (NCTC11371_00440) sufU 391798..392232 (+) 435 WP_006594962.1 Fe-S cluster assembly sulfur transfer protein SufU -

Sequence

Protein


Download         Length: 248 a.a.        Molecular weight: 28808.45 Da        Isoelectric Point: 4.0873

>NTDB_id=1141722 DQL20_RS02205 WP_006594967.1 386521..387267(+) (mecA) [Streptococcus australis strain NCTC13166]
MKMKQISDSTIKITIQLEDLEERGMEMADFLVPQEKTEEFFYTILDELEMPESFLDSGMLSFRVTPKPDKLDVFVTKSKI
DQHLNFEDFSDLPDMEELSQMSPDEFIKTLEKTISEKSKGDGDAIRHLEAEELADENQLSEEDTPNHPVDTRYIYYILQF
SQLEEVIRFTKTVHYAVETSELYKMDGVYYLTVLIDLEGCPQDYPGWLLATMREYAEDTDTTRAVLQEHGHLLLVSDAIH
ELQKVNLV

Nucleotide


Download         Length: 747 bp        

>NTDB_id=1141722 DQL20_RS02205 WP_006594967.1 386521..387267(+) (mecA) [Streptococcus australis strain NCTC13166]
ATGAAGATGAAGCAAATCAGTGATTCAACCATTAAAATCACGATTCAATTAGAGGATTTAGAAGAACGAGGCATGGAAAT
GGCCGATTTTTTGGTGCCTCAAGAAAAAACAGAAGAATTTTTCTATACCATCTTGGATGAATTGGAAATGCCAGAAAGCT
TCTTAGACAGTGGCATGTTGAGTTTCCGAGTGACTCCTAAGCCGGATAAGCTCGATGTGTTTGTGACCAAATCAAAAATT
GATCAGCATCTAAATTTTGAAGATTTTTCCGACTTGCCTGATATGGAAGAATTGTCGCAAATGTCTCCAGACGAATTTAT
CAAGACCTTGGAAAAAACCATCTCTGAAAAGAGTAAGGGAGACGGCGATGCTATCCGTCATTTAGAAGCTGAGGAATTGG
CTGATGAGAATCAGCTTTCAGAAGAAGATACGCCGAATCATCCAGTAGATACACGGTATATTTATTATATCCTCCAGTTT
TCTCAGTTAGAAGAAGTGATTCGGTTTACAAAAACAGTTCATTATGCGGTTGAGACTTCGGAACTTTATAAAATGGACGG
GGTTTACTATTTAACCGTCTTGATTGATTTGGAAGGGTGCCCGCAGGATTATCCAGGTTGGCTCTTGGCAACCATGCGTG
AATATGCGGAAGACACAGATACTACTAGAGCTGTCCTCCAGGAACACGGTCATCTCTTGCTCGTTTCAGATGCTATTCAC
GAACTACAAAAGGTCAATTTGGTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB E7S7I0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

65.854

99.194

0.653
  mecA Streptococcus pneumoniae D39

65.854

99.194

0.653
  mecA Streptococcus pneumoniae R6

65.854

99.194

0.653
  mecA Streptococcus pneumoniae TIGR4

65.854

99.194

0.653
  mecA Streptococcus mutans UA159

51.2

100

0.516
  mecA Streptococcus thermophilus LMD-9

46.185

100

0.464
  mecA Streptococcus thermophilus LMG 18311

45.783

100

0.46

Multiple sequence alignment