Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   DQN42_RS02170 Genome accession   NZ_LS483436
Coordinates   428765..430639 (+) Length   624 a.a.
NCBI ID   WP_003073669.1    Uniprot ID   A0A3R9JBZ9
Organism   Streptococcus intermedius strain NCTC11324     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 423765..435639
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN42_RS02155 (NCTC11324_00437) fmt 425771..426706 (+) 936 WP_003078292.1 methionyl-tRNA formyltransferase -
  DQN42_RS02160 (NCTC11324_00438) rsmB 426696..428009 (+) 1314 WP_003078425.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQN42_RS02165 (NCTC11324_00439) - 428028..428768 (+) 741 WP_003073671.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQN42_RS02170 (NCTC11324_00440) stkP 428765..430639 (+) 1875 WP_003073669.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQN42_RS02175 (NCTC11324_00441) liaF 430902..431600 (+) 699 WP_003078234.1 cell wall-active antibiotics response protein LiaF -
  DQN42_RS02180 (NCTC11324_00442) - 431597..432592 (+) 996 WP_003078340.1 sensor histidine kinase -
  DQN42_RS02185 (NCTC11324_00443) - 432594..433226 (+) 633 WP_003078408.1 response regulator transcription factor -
  DQN42_RS02190 (NCTC11324_00444) - 433266..434666 (+) 1401 WP_003078255.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQN42_RS02195 (NCTC11324_00445) - 434668..435060 (+) 393 WP_014829583.1 S1 RNA-binding domain-containing protein -
  DQN42_RS02200 (NCTC11324_00446) - 435180..435497 (-) 318 WP_003073656.1 DUF960 domain-containing protein -

Sequence

Protein


Download         Length: 624 a.a.        Molecular weight: 67672.81 Da        Isoelectric Point: 9.6670

>NTDB_id=1141426 DQN42_RS02170 WP_003073669.1 428765..430639(+) (stkP) [Streptococcus intermedius strain NCTC11324]
MIQVGKIFAGRYRIIKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEEGQQYLAMEYVAGLDLKRYIKEHAPLSNEEAVRIMGQILLAMRLAHTHGIVHRDLKPQNVLLTPDGDAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPNVP
QALENVVIKATAKKLTDRYQSVAEMYVDLSSCLSADRRNEKKLVFDDTVKADTKTLPKVSQNTLTSASKPTATSTKEAVD
NQTKPKPKPKKKRRLRTRYKVLLSAVVLVIAALVALVYLSPSNVKIPDVTGKTVAQARSAIEAAGLKVGKEKDEYSDSAK
KDSVIRTNPQAGTQRREGSTVDLIVSKGPKTFTMEDYSGQKKADAINSLVQKYKVSKGLIKIEEVESSDYAAGTVVSQTP
AAGSTYDLTSKNRITLKVAKTVSSVTMPSYIGSTYEFAYNNLTEVIGVQGANVEKRIVTTAPAGTQAHTIIKQSPEAKRP
LNLKNDRIVLYVYEPKTEESSTSESSSQSGSSSNKNSPSSSSSSSSGNDGSSSKTPDTSASASN

Nucleotide


Download         Length: 1875 bp        

>NTDB_id=1141426 DQN42_RS02170 WP_003073669.1 428765..430639(+) (stkP) [Streptococcus intermedius strain NCTC11324]
ATGATTCAAGTCGGCAAAATATTTGCCGGACGATATAGAATCATCAAACAAATCGGTCGAGGAGGCATGGCAGATGTTTA
CTTGGCGAAAGATTTGATTTTAGACGGGGAAGAAGTCGCGGTTAAGGTTCTAAGAACCAATTACCAGACGGACCCAATTG
CTGTAGCACGTTTTCAAAGAGAAGCACGCGCCATGGCAGATTTGGATCATCCTCATATTGTCCGGATTACCGACATTGGA
GAAGAAGAAGGCCAGCAATATCTAGCAATGGAGTATGTGGCTGGACTTGACTTGAAACGCTATATCAAAGAGCATGCTCC
TTTGTCCAATGAAGAAGCGGTGCGAATCATGGGACAAATCCTTTTGGCGATGCGTTTGGCGCATACGCATGGGATTGTTC
ACCGTGATTTAAAACCTCAAAATGTCCTTTTAACTCCAGATGGCGATGCAAAAGTAACTGACTTTGGAATTGCAGTAGCT
TTTGCAGAAACGAGTTTAACCCAGACAAATTCAATGCTGGGATCTGTACATTATCTATCACCAGAACAGGCACGTGGGTC
AAAAGCAACAGTTCAAAGTGATATTTATGCTATGGGGATTATTTTCTATGAAATGCTGACAGGTCACATTCCTTATGATG
GGGATAGTGCTGTGACGATTGCACTGCAGCATTTCCAAAAACCCCTTCCTTCTGTAATTGCTGAAAATCCAAATGTTCCA
CAAGCATTAGAAAATGTGGTTATCAAGGCAACGGCAAAAAAATTAACAGATCGTTATCAATCTGTTGCAGAAATGTATGT
TGACTTATCTAGTTGTTTATCTGCTGATCGTCGAAATGAGAAGAAATTAGTTTTTGATGATACTGTTAAAGCAGACACTA
AGACGCTTCCTAAAGTATCACAGAATACGTTGACTTCAGCGTCTAAACCGACTGCTACATCTACAAAAGAAGCTGTCGAT
AATCAAACTAAGCCTAAACCAAAACCAAAGAAAAAACGTCGTTTAAGAACGCGTTATAAAGTGTTGTTGTCGGCAGTAGT
CTTAGTTATTGCAGCTTTGGTAGCTTTAGTCTATTTGAGTCCCTCAAATGTAAAAATACCAGATGTTACTGGAAAAACCG
TCGCGCAAGCACGTTCCGCGATTGAAGCTGCAGGTTTGAAAGTTGGCAAGGAGAAAGACGAATACAGTGATTCTGCTAAG
AAAGATTCTGTCATTCGTACGAATCCACAAGCGGGAACACAACGTCGCGAAGGAAGCACAGTAGATTTGATTGTCTCAAA
AGGGCCGAAAACATTTACTATGGAAGATTATAGCGGTCAGAAAAAAGCAGATGCTATCAACAGTTTGGTGCAAAAATACA
AAGTTTCAAAGGGCTTGATTAAAATTGAAGAAGTCGAAAGTAGTGACTATGCAGCAGGAACTGTTGTTAGTCAGACGCCA
GCAGCAGGTAGTACGTATGATTTGACTTCAAAAAATCGGATTACGTTAAAAGTAGCGAAGACGGTTTCAAGTGTTACAAT
GCCAAGTTATATAGGTTCCACTTATGAATTTGCCTATAATAACCTTACCGAAGTTATTGGCGTTCAAGGAGCTAATGTTG
AAAAACGAATAGTTACAACAGCTCCAGCAGGAACACAGGCACACACGATTATTAAACAAAGCCCAGAAGCAAAGAGGCCT
CTAAATCTAAAAAATGATCGTATTGTCTTATATGTATATGAGCCAAAAACTGAAGAATCATCTACATCTGAAAGTAGTTC
GCAATCTGGAAGCAGTTCAAATAAAAATAGTCCATCATCTAGTAGTTCGTCGAGTAGCGGTAACGATGGATCAAGTTCGA
AAACACCAGACACAAGCGCTAGTGCAAGTAATTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-227)

PASTA domain (PASTA)

(433-500)

PASTA domain (PASTA)

(505-573)

PASTA domain (PASTA)

(364-427)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3R9JBZ9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

66.381

93.429

0.62
  stkP Streptococcus pneumoniae D39

66.038

93.429

0.617
  stkP Streptococcus pneumoniae R6

66.038

93.429

0.617
  stkP Streptococcus pneumoniae Rx1

65.866

93.429

0.615
  pknB Streptococcus mutans UA159

59.658

93.75

0.559
  stkP/pknB Streptococcus salivarius strain HSISS4

59.294

86.218

0.511

Multiple sequence alignment