Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQN42_RS01995 Genome accession   NZ_LS483436
Coordinates   392533..393282 (+) Length   249 a.a.
NCBI ID   WP_003073748.1    Uniprot ID   A0A3R9JLV5
Organism   Streptococcus intermedius strain NCTC11324     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 387533..398282
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN42_RS01980 (NCTC11324_00402) - 387917..389482 (-) 1566 WP_004234074.1 ABC transporter substrate-binding protein/permease -
  DQN42_RS01985 (NCTC11324_00403) - 389608..391497 (+) 1890 WP_003078231.1 DUF2207 domain-containing protein -
  DQN42_RS01990 (NCTC11324_00404) - 391564..392406 (+) 843 WP_003078379.1 undecaprenyl-diphosphate phosphatase -
  DQN42_RS01995 (NCTC11324_00405) mecA 392533..393282 (+) 750 WP_003073748.1 adaptor protein MecA Regulator
  DQN42_RS02000 (NCTC11324_00406) - 393279..394445 (+) 1167 WP_003073746.1 glycosyltransferase family 4 protein -
  DQN42_RS02005 (NCTC11324_00407) sufC 394536..395306 (+) 771 WP_003073743.1 Fe-S cluster assembly ATPase SufC -
  DQN42_RS02010 (NCTC11324_00408) sufD 395346..396608 (+) 1263 WP_004234067.1 Fe-S cluster assembly protein SufD -
  DQN42_RS02015 (NCTC11324_00409) - 396625..397857 (+) 1233 WP_003078307.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 28908.68 Da        Isoelectric Point: 4.2084

>NTDB_id=1141424 DQN42_RS01995 WP_003073748.1 392533..393282(+) (mecA) [Streptococcus intermedius strain NCTC11324]
MEMKQISDTTIKITIKLEDLEERGMEMADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDRLDVFVTKSKI
DKNLNFDDLADLPDVEELSQMSPDEFLKTLEKNIFEKSKDDIEAVRSLETAEAENSRSTSDMEEQEEDNDELTQKYIYYI
LKFANLREVIVFAKTVDYTVNTSELYKMGSHYYLTILVDIEGHPKRYPAWLLASMREHAEDTAVTRAVLQEHGYLLLVND
AVSNLQKVK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1141424 DQN42_RS01995 WP_003073748.1 392533..393282(+) (mecA) [Streptococcus intermedius strain NCTC11324]
ATGGAAATGAAGCAAATTAGTGATACAACGATTAAAATCACAATAAAATTAGAAGATTTAGAAGAACGTGGAATGGAGAT
GGCAGATTTTCTCGTTCCGCAAGAAAAGACAGAAGAGTTTTTCTATGCAATTTTAGATGAGTTGGAAATGCCAGAGAGTT
TTTTGGATAGCGGTATGCTCAGTTTTCGTGTAACCCCTAAACCAGACCGACTGGATGTTTTTGTCACCAAGTCTAAGATT
GATAAGAATCTGAATTTTGATGATTTAGCAGATTTACCAGATGTAGAAGAGCTGTCTCAAATGTCTCCAGATGAATTTTT
AAAGACATTAGAAAAAAATATTTTTGAGAAAAGCAAAGACGATATTGAAGCTGTTCGGTCTTTGGAAACGGCAGAAGCAG
AAAATAGTAGAAGCACTTCTGATATGGAAGAACAAGAGGAAGATAATGACGAGCTAACACAAAAATATATATATTACATT
TTGAAGTTTGCCAACCTAAGAGAAGTGATTGTTTTTGCTAAAACGGTAGATTATACCGTCAATACTTCAGAGTTATACAA
AATGGGCAGTCACTATTATTTGACAATTTTGGTTGATATTGAAGGCCACCCTAAGCGATATCCGGCTTGGCTTCTTGCAT
CTATGCGTGAACATGCAGAAGATACAGCTGTGACAAGAGCTGTTTTGCAAGAGCATGGTTACTTATTGCTTGTCAACGAT
GCGGTTTCCAATCTTCAAAAGGTTAAATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3R9JLV5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

68.145

99.598

0.679
  mecA Streptococcus pneumoniae D39

68.145

99.598

0.679
  mecA Streptococcus pneumoniae R6

68.145

99.598

0.679
  mecA Streptococcus pneumoniae TIGR4

67.742

99.598

0.675
  mecA Streptococcus mutans UA159

51.613

99.598

0.514
  mecA Streptococcus thermophilus LMD-9

46.094

100

0.474
  mecA Streptococcus thermophilus LMG 18311

45.703

100

0.47

Multiple sequence alignment