Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQN31_RS01395 Genome accession   NZ_LS483421
Coordinates   250898..251659 (+) Length   253 a.a.
NCBI ID   WP_014407297.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC10877     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 245898..256659
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN31_RS01380 (NCTC10877_00273) - 246156..247724 (-) 1569 WP_014407294.1 ABC transporter substrate-binding protein/permease -
  DQN31_RS01385 (NCTC10877_00274) - 247922..249847 (+) 1926 WP_014407295.1 DUF2207 domain-containing protein -
  DQN31_RS01390 (NCTC10877_00275) - 249913..250752 (+) 840 WP_014407296.1 undecaprenyl-diphosphate phosphatase -
  DQN31_RS01395 (NCTC10877_00276) mecA 250898..251659 (+) 762 WP_014407297.1 adaptor protein MecA Regulator
  DQN31_RS01400 (NCTC10877_00277) - 251666..252835 (+) 1170 WP_014407298.1 glycosyltransferase family 4 protein -
  DQN31_RS01405 (NCTC10877_00278) sufC 252957..253727 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  DQN31_RS01410 (NCTC10877_00279) sufD 253822..255084 (+) 1263 WP_014407299.1 Fe-S cluster assembly protein SufD -
  DQN31_RS01415 (NCTC10877_00280) - 255115..256341 (+) 1227 WP_011054183.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29078.75 Da        Isoelectric Point: 4.1622

>NTDB_id=1141039 DQN31_RS01395 WP_014407297.1 250898..251659(+) (mecA) [Streptococcus pyogenes strain NCTC10877]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGNNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=1141039 DQN31_RS01395 WP_014407297.1 250898..251659(+) (mecA) [Streptococcus pyogenes strain NCTC10877]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCTACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAACAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

62.8

98.814

0.621
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.627

100

0.49
  mecA Streptococcus pneumoniae D39

48.627

100

0.49
  mecA Streptococcus pneumoniae R6

48.627

100

0.49
  mecA Streptococcus pneumoniae TIGR4

48.627

100

0.49

Multiple sequence alignment