Detailed information NTG1141026

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQN75_RS08975
• Genome accession: NZ_LS483420
• Coordinates: 1783560..1784783 (+)
• Length: 407 a.a.
• NCBI ID: WP_111685357.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC13739
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1778560..1789783

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN75_RS08960 (NCTC13739_01770)	-	1781697..1782474 (-)	778	Protein_1660	IS30 family transposase	-
DQN75_RS08970 (NCTC13739_01773)	rlmH	1782869..1783348 (-)	480	WP_002981964.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQN75_RS08975 (NCTC13739_01774)	htrA	1783560..1784783 (+)	1224	WP_111685357.1	S1C family serine protease	Regulator
DQN75_RS08980 (NCTC13739_01775)	spo0J	1784872..1785648 (+)	777	WP_014407987.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42760.38 Da
• Isoelectric Point: 7.3920

>NTDB_id=1141026 DQN75_RS08975 WP_111685357.1 1783560..1784783(+) (htrA) [Streptococcus pyogenes strain NCTC13739]
MPSMKHILKSLSILLVGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
TLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=1141026 DQN75_RS08975 WP_111685357.1 1783560..1784783(+) (htrA) [Streptococcus pyogenes strain NCTC13739]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTATTTTACTAGTTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTCAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
ACCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGACTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGACGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (301-396)

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.881	99.263	0.614
htrA	Streptococcus gordonii str. Challis substr. CH1	55.473	98.771	0.548
htrA	Streptococcus mitis NCTC 12261	52.58	100	0.526
htrA	Streptococcus pneumoniae Rx1	52.334	100	0.523
htrA	Streptococcus pneumoniae D39	52.334	100	0.523
htrA	Streptococcus pneumoniae R6	52.334	100	0.523
htrA	Streptococcus pneumoniae TIGR4	52.334	100	0.523