Detailed information NTG1140974

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQM62_RS09915
• Genome accession: NZ_LS483418
• Coordinates: 1982152..1983348 (+)
• Length: 398 a.a.
• NCBI ID: WP_012028059.1
• Uniprot ID: D5AF49
• Organism: Streptococcus suis strain NCTC10234
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1977152..1988348

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM62_RS09885 (NCTC10234_01943)	-	1977811..1980390 (+)	2580	WP_012028056.1	YfhO family protein	-
DQM62_RS09905	-	1980791..1981474 (-)	684	WP_012775416.1	YoaK family protein	-
DQM62_RS09910 (NCTC10234_01947)	rlmH	1981499..1981978 (-)	480	WP_012028058.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQM62_RS09915 (NCTC10234_01948)	htrA	1982152..1983348 (+)	1197	WP_012028059.1	S1C family serine protease	Regulator
DQM62_RS09920 (NCTC10234_01949)	spo0J	1983409..1984173 (+)	765	WP_012775418.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41866.92 Da
• Isoelectric Point: 4.6543

>NTDB_id=1140974 DQM62_RS09915 WP_012028059.1 1982152..1983348(+) (htrA) [Streptococcus suis strain NCTC10234]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPQVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGVIFGNIESSDELAVAGEGSGVIYKKYGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSKDGQTISTNAIQTDTAINPGNSGGPLIN
TQGQVIGITSSKITSSSANSSGVAVEGLGFAIPANDAVAIINQLEKTGQVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide

• Length: 1197 bp

>NTDB_id=1140974 DQM62_RS09915 WP_012028059.1 1982152..1983348(+) (htrA) [Streptococcus suis strain NCTC10234]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTTTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTGTCAGCCTCTTTCTTCCAGCCACAGGTGCAACAAGCAAATTCTGCTATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCCACCACAAAAGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAATCAGCC
AACAATAGTCTTGGTGTTATCTTTGGAAATATTGAATCATCTGACGAACTAGCTGTTGCTGGAGAGGGGTCTGGGGTTAT
CTATAAAAAATATGGTCAATATGCCTATATTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATCCTTT
TAGCATCTGGAGAAAAAATTAGCGGTGAACTTGTTGGTTCCGATACATATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCCAATACAGTTACCCAGGGTATTATTTCTAGCTTAAGTCGGACAGTTACTTCACAATCAAAAG
ATGGACAAACAATCTCAACTAACGCTATTCAAACTGATACAGCTATCAACCCTGGAAACTCTGGCGGACCGTTAATCAAT
ACCCAAGGACAAGTGATAGGCATTACCTCTAGCAAAATTACCTCAAGTTCTGCAAATAGCTCAGGCGTGGCTGTAGAAGG
GTTGGGATTTGCTATTCCTGCAAATGATGCCGTAGCTATTATCAATCAGCTTGAAAAAACTGGACAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTAGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTAGTAATTGTCTCTACACAAAGTGGGCTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (293-389)

3D structure

• AlphaFold DB: D5AF49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	59.194	99.749	0.59
htrA	Streptococcus gordonii str. Challis substr. CH1	58.987	99.246	0.585
htrA	Streptococcus pneumoniae D39	57.252	98.744	0.565
htrA	Streptococcus pneumoniae TIGR4	57.252	98.744	0.565
htrA	Streptococcus mitis NCTC 12261	57.252	98.744	0.565
htrA	Streptococcus pneumoniae R6	57.252	98.744	0.565
htrA	Streptococcus pneumoniae Rx1	57.252	98.744	0.565