Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   T303_RS02020 Genome accession   NZ_CP006819
Coordinates   355123..355872 (+) Length   249 a.a.
NCBI ID   WP_011680667.1    Uniprot ID   Q03MN5
Organism   Streptococcus thermophilus ASCC 1275     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 350123..360872
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  T303_RS10995 (T303_02040) - 350699..350869 (+) 171 WP_011680664.1 hypothetical protein -
  T303_RS09930 (T303_02045) - 350956..351063 (+) 108 WP_011226802.1 LPXTG cell wall anchor domain-containing protein -
  T303_RS02005 (T303_02050) - 351150..351890 (-) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  T303_RS02010 (T303_02055) - 351890..353440 (-) 1551 WP_011680665.1 ABC transporter substrate-binding protein/permease -
  T303_RS02015 (T303_02060) - 353643..354497 (+) 855 WP_011680666.1 undecaprenyl-diphosphate phosphatase -
  T303_RS09935 - 354549..354857 (-) 309 WP_306496352.1 DUF3021 family protein -
  T303_RS02020 (T303_02065) mecA 355123..355872 (+) 750 WP_011680667.1 adaptor protein MecA Regulator
  T303_RS02025 (T303_02070) - 355876..357033 (+) 1158 WP_002947632.1 MraY family glycosyltransferase -
  T303_RS02030 (T303_02075) sufC 357193..357963 (+) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  T303_RS02035 (T303_02080) sufD 358000..359262 (+) 1263 WP_011680669.1 Fe-S cluster assembly protein SufD -
  T303_RS02040 (T303_02085) - 359316..360548 (+) 1233 WP_011680670.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29174.68 Da        Isoelectric Point: 4.0481

>NTDB_id=114074 T303_RS02020 WP_011680667.1 355123..355872(+) (mecA) [Streptococcus thermophilus ASCC 1275]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=114074 T303_RS02020 WP_011680667.1 355123..355872(+) (mecA) [Streptococcus thermophilus ASCC 1275]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q03MN5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

100

100

1
  mecA Streptococcus thermophilus LMG 18311

99.197

100

0.992
  mecA Streptococcus mutans UA159

57.787

97.992

0.566
  mecA Streptococcus pneumoniae Rx1

46.586

100

0.466
  mecA Streptococcus pneumoniae D39

46.586

100

0.466
  mecA Streptococcus pneumoniae R6

46.586

100

0.466
  mecA Streptococcus pneumoniae TIGR4

46.586

100

0.466

Multiple sequence alignment