Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQN40_RS06735 Genome accession   NZ_LS483413
Coordinates   1331386..1332060 (+) Length   224 a.a.
NCBI ID   WP_014612304.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC7136     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1326386..1337060
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN40_RS06720 (NCTC7136_01397) pstB 1326955..1327713 (+) 759 WP_003057749.1 phosphate ABC transporter ATP-binding protein PstB -
  DQN40_RS06725 (NCTC7136_01398) phoU 1327791..1328444 (+) 654 WP_111679149.1 phosphate signaling complex protein PhoU -
  DQN40_RS06730 (NCTC7136_01399) - 1328645..1331182 (+) 2538 WP_084916834.1 M1 family metallopeptidase -
  DQN40_RS06735 (NCTC7136_01400) ciaR 1331386..1332060 (+) 675 WP_014612304.1 response regulator transcription factor Regulator
  DQN40_RS06740 (NCTC7136_01401) ciaH 1332053..1333363 (+) 1311 WP_014612303.1 HAMP domain-containing sensor histidine kinase Regulator
  DQN40_RS06745 (NCTC7136_01402) rpsT 1333521..1333769 (-) 249 WP_009881183.1 30S ribosomal protein S20 -
  DQN40_RS06750 (NCTC7136_01403) coaA 1333823..1334743 (-) 921 WP_084916836.1 type I pantothenate kinase -
  DQN40_RS06755 (NCTC7136_01404) - 1335011..1335610 (+) 600 WP_015057597.1 class I SAM-dependent methyltransferase -
  DQN40_RS06760 (NCTC7136_01405) - 1335597..1336874 (+) 1278 WP_015017041.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25592.57 Da        Isoelectric Point: 4.4128

>NTDB_id=1140711 DQN40_RS06735 WP_014612304.1 1331386..1332060(+) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC7136]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGQGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGQKEVQVDGRPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVDKLQTLRSVGYILKSHE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1140711 DQN40_RS06735 WP_014612304.1 1331386..1332060(+) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC7136]
ATGATCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATTATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACAGGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACAGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAATGTCGTAG
TGGATTTAGGACAAAAAGAAGTTCAAGTGGATGGCCGGCCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTGTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATTTTGTGGACAAACTGCAGACATTGA
GAAGCGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

84.163

98.661

0.83
  ciaR Streptococcus pneumoniae D39

84.163

98.661

0.83
  ciaR Streptococcus pneumoniae R6

84.163

98.661

0.83
  ciaR Streptococcus pneumoniae TIGR4

84.163

98.661

0.83
  ciaR Streptococcus mutans UA159

83.71

98.661

0.826
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.326

100

0.388
  vicR Streptococcus mutans UA159

35.443

100

0.375

Multiple sequence alignment