Detailed information NTG1140587

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: DQN21_RS11065
• Genome accession: NZ_LS483409
• Coordinates: 2215462..2216190 (-)
• Length: 242 a.a.
• NCBI ID: WP_012962512.1
• Uniprot ID: A0A139R4K2
• Organism: Streptococcus gallolyticus strain NCTC13773
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2210462..2221190

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN21_RS11030 (NCTC13773_02241)	-	2211066..2211695 (-)	630	WP_013643475.1	thiamine diphosphokinase	-
DQN21_RS11035 (NCTC13773_02242)	rpe	2211688..2212350 (-)	663	WP_013643476.1	ribulose-phosphate 3-epimerase	-
DQN21_RS11040 (NCTC13773_02243)	rsgA	2212357..2213229 (-)	873	WP_077497721.1	ribosome small subunit-dependent GTPase A	-
DQN21_RS11055 (NCTC13773_02246)	-	2213752..2213952 (-)	201	WP_077497723.1	bacteriocin	-
DQN21_RS11060 (NCTC13773_02247)	comD/comD3	2214085..2215449 (-)	1365	WP_077497726.1	sensor histidine kinase	Regulator
DQN21_RS11065 (NCTC13773_02248)	comE/comE2	2215462..2216190 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
DQN21_RS11070 (NCTC13773_02249)	-	2216289..2216582 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
DQN21_RS11075 (NCTC13773_02250)	-	2216633..2216785 (-)	153	WP_231873055.1	hypothetical protein	-
DQN21_RS11080 (NCTC13773_02251)	-	2217129..2217440 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
DQN21_RS11085 (NCTC13773_02252)	-	2217452..2217601 (-)	150	WP_013643483.1	hypothetical protein	-
DQN21_RS11090 (NCTC13773_02253)	-	2217658..2217909 (-)	252	WP_231844599.1	DUF3884 family protein	-
DQN21_RS12630 (NCTC13773_02254)	-	2218210..2218350 (+)	141	WP_014295304.1	hypothetical protein	-
DQN21_RS11095 (NCTC13773_02255)	-	2218367..2219677 (-)	1311	WP_058621373.1	sensor histidine kinase	-
DQN21_RS11100 (NCTC13773_02256)	comE/comE1	2219682..2220413 (-)	732	WP_077497729.1	response regulator transcription factor	Regulator
DQN21_RS11105 (NCTC13773_02257)	-	2220430..2220756 (-)	327	WP_009855002.1	LytTR family DNA-binding domain-containing protein	-

Sequence

Protein

• Length: 242 a.a.
• Molecular weight: 28063.45 Da
• Isoelectric Point: 6.7499

>NTDB_id=1140587 DQN21_RS11065 WP_012962512.1 2215462..2216190(-) (comE/comE2) [Streptococcus gallolyticus strain NCTC13773]
MIDIYVLEDDVNQQFRLEKMIDEVLVDNQWQHRCFELFGEPSRLITLIDETVPQIFFLDLDINGDKTKGIEVAKAIRDVS
KTATLVFVTTHSEFMLLTYRAQVSALDFIDKTDSDLAIKENLQACLKKVVEGQVPRLSLDTFIFENNKTKIRIPFEDILY
FETAEAHRLMLVTRTGQRNFYGTIREVKKANHKLFQCHKSYLINPDNVVSLDKKEGLVYFVGGKSCYVSKKHMKELKTKL
ES

Nucleotide

• Length: 729 bp

>NTDB_id=1140587 DQN21_RS11065 WP_012962512.1 2215462..2216190(-) (comE/comE2) [Streptococcus gallolyticus strain NCTC13773]
ATGATTGATATTTATGTTTTGGAAGATGACGTAAATCAGCAGTTTCGCTTGGAAAAAATGATTGACGAGGTGCTTGTGGA
CAATCAGTGGCAACATCGTTGTTTTGAATTGTTTGGTGAGCCCAGTCGTCTTATCACTCTTATTGATGAAACGGTTCCTC
AAATCTTTTTCTTGGATTTGGATATCAATGGCGATAAAACGAAAGGAATTGAAGTTGCCAAGGCGATTAGAGACGTTTCG
AAAACAGCAACACTTGTCTTTGTTACAACGCATTCTGAATTTATGCTCCTGACCTATCGTGCGCAAGTCAGTGCCCTTGA
TTTCATTGATAAAACTGACAGTGACTTGGCAATCAAGGAAAATTTGCAGGCTTGTTTAAAGAAAGTCGTTGAAGGACAAG
TGCCTCGCCTAAGCTTGGATACCTTTATTTTTGAAAACAATAAAACTAAAATCAGAATACCGTTTGAAGATATTCTTTAT
TTTGAAACGGCGGAAGCGCACCGTTTGATGTTGGTGACACGGACAGGACAGCGTAATTTTTACGGAACAATTAGAGAAGT
TAAAAAGGCAAATCATAAGCTATTTCAATGCCATAAATCCTATCTGATTAATCCTGATAATGTCGTCAGTTTGGATAAAA
AAGAAGGGCTTGTTTATTTTGTAGGTGGAAAATCTTGCTACGTTTCCAAAAAACACATGAAAGAATTAAAAACTAAACTA
GAAAGTTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (5-113)

3D structure

• AlphaFold DB: A0A139R4K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	70.248	100	0.702
comE/comE1	Streptococcus equinus JB1	43.802	100	0.438
comE/blpR	Streptococcus mutans UA159	42.739	99.587	0.426