Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQN21_RS03075 Genome accession   NZ_LS483409
Coordinates   555251..557128 (+) Length   625 a.a.
NCBI ID   WP_012961536.1    Uniprot ID   -
Organism   Streptococcus gallolyticus strain NCTC13773     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 550251..562128
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN21_RS03060 (NCTC13773_00616) fmt 552229..553164 (+) 936 WP_077496359.1 methionyl-tRNA formyltransferase -
  DQN21_RS03065 (NCTC13773_00617) rsmB 553154..554476 (+) 1323 WP_077496361.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQN21_RS03070 (NCTC13773_00618) - 554514..555251 (+) 738 WP_009853567.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQN21_RS03075 (NCTC13773_00619) pknB 555251..557128 (+) 1878 WP_012961536.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQN21_RS03080 (NCTC13773_00620) liaF 557239..557934 (+) 696 WP_009853569.1 cell wall-active antibiotics response protein LiaF -
  DQN21_RS03085 (NCTC13773_00621) - 557931..558956 (+) 1026 WP_012961538.1 sensor histidine kinase -
  DQN21_RS03090 (NCTC13773_00622) - 558940..559584 (+) 645 WP_009853571.1 response regulator transcription factor -
  DQN21_RS03095 (NCTC13773_00623) - 559703..561103 (+) 1401 WP_077496363.1 Cof-type HAD-IIB family hydrolase -
  DQN21_RS03100 (NCTC13773_00624) - 561103..561459 (+) 357 WP_003063541.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 625 a.a.        Molecular weight: 67656.85 Da        Isoelectric Point: 5.0759

>NTDB_id=1140551 DQN21_RS03075 WP_012961536.1 555251..557128(+) (pknB) [Streptococcus gallolyticus strain NCTC13773]
MIQIGKLFAGRYRILKSIGRGGMADVYLAKDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKDGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENKNVP
QALENVVIKATAKRLSDRYASTFEMSRDLMTALSYNRSREPKLVFEDTENTKTLPKVTTSTSVPSTTEQLLKKQKAAKED
KAATENKATKAKTKKKKSRRMFGTLMKIFFAVVIVAIAIFTYLTLTSPSTVSVPDVAGSSLSEAKTTIKSSGLKVGTVHK
VSSDTVESGYVIKTSPTAGSSKKEGSSIDIYVSKGSSGFKIKDYTGQDYQTAVKDLVNNYGVSESQIEIEEVSTSDYDEG
VIISQTPSEGETFKVSGDDKITFKVAAESTVTMPNLTGYTYSEAIAALTALGVSSSHITVYQADPNSSTGYVQVSSPSST
ATVTAQTPYYGETLSGNVVLYLAADEEESSQAPSSSSSESSESKESSSSSSSTDDSSSSTETSDE

Nucleotide


Download         Length: 1878 bp        

>NTDB_id=1140551 DQN21_RS03075 WP_012961536.1 555251..557128(+) (pknB) [Streptococcus gallolyticus strain NCTC13773]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATCCTCAAATCTATCGGACGGGGTGGAATGGCAGATGTTTA
TCTGGCAAAAGATCTCATTCTTGATAATGAAGAAGTTGCCATTAAGGTGCTTCGGACGAATTATCAGACTGATCAAATTG
CCGTAGCGCGTTTCCAACGGGAAGCGCGTGCCATGGCAGAACTGAACCATCCAAATATCGTCTCGATTCGTGATATTGGA
GAAGAAGACGGACAGCAATTCTTAGTAATGGAATATGTTGATGGCTCGGACTTGAAAAAATACATTCAAGATCATGCTCC
GCTTTCTAATAATGAAGTTGTTAGAATCATGGAAGAAGTCTTATCTGCGATGACTTTGGCGCATCAACAAGGAATTGTTC
ACCGTGATTTAAAACCACAAAATATCTTATTAACCAAAGACGGAACTGTTAAAGTTACTGACTTTGGTATCGCCGTAGCC
TTTGCCGAAACAAGTTTAACGCAAACCAATTCAATGCTAGGTAGTGTGCATTATTTATCGCCTGAACAAGCACGTGGTTC
AAAAGCGACTGTTCAAAGTGATATTTACGCTATGGGGATTATGTTGTTTGAAATGTTAACAGGTCACATCCCATATGATG
GCGATTCAGCTGTTACCATTGCGCTTCAACATTTCCAAAAACCACTTCCTTCCATCATTGATGAGAATAAAAATGTGCCA
CAAGCACTAGAAAATGTTGTTATCAAGGCGACTGCAAAACGTTTAAGTGACCGTTATGCGTCAACTTTTGAAATGAGTCG
TGATTTGATGACGGCACTTTCTTACAACCGTAGCCGTGAACCTAAACTTGTTTTTGAAGATACTGAAAATACAAAGACAC
TTCCAAAGGTAACAACATCAACATCTGTTCCTTCAACGACAGAACAACTCTTGAAGAAACAAAAAGCAGCTAAAGAAGAT
AAAGCAGCAACAGAAAACAAAGCGACTAAGGCTAAAACAAAGAAGAAAAAATCACGTCGTATGTTCGGCACATTGATGAA
AATCTTTTTTGCAGTTGTGATTGTAGCTATTGCTATCTTTACTTACTTGACGTTGACCTCACCATCAACCGTGAGTGTTC
CAGATGTTGCTGGCTCTAGTTTATCAGAAGCAAAAACAACGATAAAATCATCAGGTCTTAAAGTTGGAACCGTTCATAAA
GTATCAAGTGATACCGTTGAGAGTGGTTATGTTATTAAGACAAGTCCAACTGCTGGTTCATCGAAAAAAGAAGGGTCATC
AATTGATATTTACGTATCAAAAGGCTCATCAGGATTCAAGATAAAAGACTATACAGGTCAAGATTATCAAACAGCCGTTA
AAGATTTGGTCAATAATTACGGTGTTTCAGAGTCGCAAATTGAGATTGAAGAAGTCTCAACGTCAGACTATGACGAAGGT
GTTATCATCAGTCAAACGCCTAGCGAAGGTGAAACCTTTAAGGTAAGTGGCGATGATAAGATTACCTTTAAAGTAGCCGC
AGAAAGCACAGTAACAATGCCAAATCTGACAGGCTATACTTATTCAGAAGCTATTGCTGCCTTGACGGCTCTAGGTGTGT
CAAGTTCACATATTACGGTTTATCAAGCCGACCCAAATTCTTCTACGGGTTATGTGCAAGTAAGCTCACCATCTTCAACA
GCAACTGTCACTGCTCAGACACCTTATTATGGTGAAACGTTAAGTGGTAACGTGGTACTTTACCTAGCAGCTGATGAAGA
AGAAAGCTCACAGGCACCATCGTCATCAAGCTCAGAATCCTCTGAATCAAAAGAATCAAGTTCATCAAGCAGTAGTACAG
ATGACAGTAGCTCATCGACAGAAACAAGTGATGAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(371-434)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(511-575)

Protein kinase domain (Pkinase)

(12-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

68.313

93.92

0.642
  stkP/pknB Streptococcus salivarius strain HSISS4

65.025

94.24

0.613
  stkP Streptococcus pneumoniae TIGR4

54.795

93.44

0.512
  stkP Streptococcus pneumoniae D39

54.623

93.44

0.51
  stkP Streptococcus pneumoniae R6

54.623

93.44

0.51
  stkP Streptococcus pneumoniae Rx1

54.452

93.44

0.509

Multiple sequence alignment