Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQN33_RS07405 Genome accession   NZ_LS483408
Coordinates   1496924..1498810 (-) Length   628 a.a.
NCBI ID   WP_046391537.1    Uniprot ID   -
Organism   Streptococcus uberis strain NCTC4674     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1491924..1503810
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN33_RS07380 (NCTC4674_01569) - 1492686..1493042 (-) 357 WP_015911700.1 S1 RNA-binding domain-containing protein -
  DQN33_RS07385 (NCTC4674_01570) - 1493042..1494442 (-) 1401 WP_046393652.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQN33_RS07390 (NCTC4674_01571) - 1494476..1495117 (-) 642 WP_015911702.1 response regulator transcription factor -
  DQN33_RS07395 (NCTC4674_01572) - 1495110..1496114 (-) 1005 WP_037593424.1 sensor histidine kinase -
  DQN33_RS07400 (NCTC4674_01573) liaF 1496111..1496806 (-) 696 WP_046388758.1 cell wall-active antibiotics response protein LiaF -
  DQN33_RS07405 (NCTC4674_01574) pknB 1496924..1498810 (-) 1887 WP_046391537.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQN33_RS07410 (NCTC4674_01575) - 1498807..1499547 (-) 741 WP_015911706.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQN33_RS07415 (NCTC4674_01576) rsmB 1499585..1500907 (-) 1323 WP_015911707.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQN33_RS07420 (NCTC4674_01577) fmt 1500897..1501832 (-) 936 WP_015911708.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 628 a.a.        Molecular weight: 68301.42 Da        Isoelectric Point: 8.9129

>NTDB_id=1140518 DQN33_RS07405 WP_046391537.1 1496924..1498810(-) (pknB) [Streptococcus uberis strain NCTC4674]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKSGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLYEMLTGHIPYDGDSAVTIALQHFQKPLPSILDENKMVP
QALENVVIKATAKKLSDRYASTFDMSRDLMTALSYNRSREKKLVFEDGDSTKPLPKVSPTPNVTPKSSPTVSATKANEPA
KQDYLQKPQKERKRGRFLGTLFKILFALFVVGVAIFTFLILTKPSTVKVPNLNGSTLSVAKTELKTMGFKVGDIKKIESG
TVAVGHVVKTDPSAGTAKREGATIDIFVSSGKKGFVMEDYTGQNYQDVISNLMTTYGVSRSKIKIKRINTNDYQADTVIS
QTPDKGEKFNPDGKSKITLSVASSGTVTMPDLTGYTYQEALNELTALGINTNRIKTYYTNGSSGEKKSMIVSEQTPYAYS
SISLSDSSEISLGLYAATETSNSSTPSSSSEVSSSSSSSTYDPGISSETTTSSSSSSTNAGLDPNHNP

Nucleotide


Download         Length: 1887 bp        

>NTDB_id=1140518 DQN33_RS07405 WP_046391537.1 1496924..1498810(-) (pknB) [Streptococcus uberis strain NCTC4674]
ATGATACAGATTGGCAAATTATTTGCTGGTCGTTATCGCATCTTAAAATCAATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGACTTGATATTAGATAATGAGGACGTAGCTATTAAGGTATTACGTACAAATTATCAAACAGATCAGGTTG
CAGTTGCACGTTTTCAACGAGAAGCGCGTGCGATGGCAGAATTAAATCATCCGAACATTGTAGCCATACGAGATATAGGT
GAAGAAGACGGACAGCAGTTTTTAGTAATGGAATACGTCGATGGTGCAGACTTGAAAAAATACATTCAAGATCATGCTCC
ATTGTCTAACAACGAAGTTGTTAGAATTATGGAGGAAGTTCTCTCTGCAATGACACTTGCTCACCAAAAGGGCATTGTTC
ATAGGGACTTAAAACCTCAAAATATTTTATTAACCAAATCTGGAGTCGTTAAAGTAACTGATTTTGGTATAGCTGTTGCA
TTTGCTGAAACGAGTTTAACCCAAACAAACTCCATGTTAGGAAGTGTGCATTATTTATCTCCAGAACAAGCTCGTGGCTC
AAAAGCGACTATTCAGAGCGATATATATGCAATGGGTATCATGCTTTATGAAATGTTGACTGGACATATTCCATATGATG
GAGATAGTGCAGTTACCATTGCTTTACAACATTTCCAAAAACCATTACCATCTATTTTAGATGAAAATAAAATGGTGCCA
CAAGCTTTGGAAAATGTGGTCATAAAAGCTACAGCTAAGAAGCTGAGTGATCGCTATGCTTCGACATTTGACATGAGCAG
GGATTTAATGACGGCTCTAAGCTATAATAGAAGCCGTGAGAAAAAATTAGTGTTTGAGGATGGCGACAGTACAAAGCCAT
TACCAAAAGTTTCTCCAACACCAAATGTAACCCCTAAATCATCTCCAACAGTTTCAGCAACTAAGGCAAATGAGCCTGCA
AAACAAGACTACTTGCAAAAACCACAAAAAGAGAGAAAACGAGGTCGTTTTTTAGGCACTTTATTCAAAATTCTCTTTGC
CCTATTTGTCGTAGGTGTGGCAATCTTTACCTTCCTTATTTTGACGAAACCATCAACGGTCAAAGTTCCTAATTTAAATG
GTTCAACTTTATCTGTCGCTAAAACTGAATTGAAAACAATGGGATTTAAAGTTGGAGATATCAAAAAAATAGAAAGTGGA
ACTGTTGCGGTAGGTCATGTTGTTAAAACAGATCCTAGTGCTGGTACAGCAAAACGTGAAGGAGCCACTATTGATATATT
TGTATCATCTGGGAAAAAAGGTTTTGTCATGGAAGATTACACAGGACAAAATTACCAAGATGTTATTTCTAATCTGATGA
CTACTTATGGTGTTTCTCGTTCTAAAATCAAAATTAAACGAATCAACACAAATGACTATCAAGCAGATACAGTTATTAGC
CAAACGCCGGATAAAGGTGAAAAATTCAATCCGGATGGTAAGTCAAAAATTACCTTAAGTGTGGCATCAAGTGGAACTGT
TACAATGCCAGATTTAACAGGATATACTTACCAAGAAGCATTAAACGAATTGACTGCTTTAGGCATTAACACAAACCGGA
TCAAGACTTACTATACTAATGGTTCAAGTGGTGAAAAGAAATCCATGATTGTCTCAGAGCAAACCCCTTACGCTTATTCA
AGCATTTCTCTTTCTGATTCTAGTGAAATTAGTTTAGGATTATATGCCGCTACAGAAACGTCGAACAGCTCAACACCATC
AAGTTCAAGTGAAGTTTCCTCTTCTAGTAGTTCATCGACATATGATCCAGGAATTTCTTCAGAAACAACAACATCAAGTT
CTTCTTCTTCGACAAATGCGGGACTTGATCCAAATCACAATCCATAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-253)

PASTA domain (PASTA)

(367-429)

PASTA domain (PASTA)

(436-502)

PASTA domain (PASTA)

(507-572)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.753

92.994

0.611
  stkP/pknB Streptococcus salivarius strain HSISS4

62.742

90.605

0.568
  stkP Streptococcus pneumoniae TIGR4

53.422

95.382

0.51
  stkP Streptococcus pneumoniae D39

53.255

95.382

0.508
  stkP Streptococcus pneumoniae R6

53.255

95.382

0.508
  stkP Streptococcus pneumoniae Rx1

53.088

95.382

0.506

Multiple sequence alignment