Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQN33_RS04950 Genome accession   NZ_LS483408
Coordinates   974232..974906 (-) Length   224 a.a.
NCBI ID   WP_012658457.1    Uniprot ID   A0A2X4ES39
Organism   Streptococcus uberis strain NCTC4674     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 969232..979906
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN33_RS04925 (NCTC4674_01019) - 969502..970779 (-) 1278 WP_012658452.1 pyrimidine-nucleoside phosphorylase -
  DQN33_RS04930 (NCTC4674_01020) - 970776..971366 (-) 591 WP_012658453.1 class I SAM-dependent methyltransferase -
  DQN33_RS04935 (NCTC4674_01021) coaA 971630..972550 (+) 921 WP_046389364.1 type I pantothenate kinase -
  DQN33_RS04940 (NCTC4674_01022) rpsT 972610..972852 (+) 243 WP_160463058.1 30S ribosomal protein S20 -
  DQN33_RS04945 (NCTC4674_01023) ciaH 972929..974239 (-) 1311 WP_037592122.1 sensor histidine kinase Regulator
  DQN33_RS04950 (NCTC4674_01024) ciaR 974232..974906 (-) 675 WP_012658457.1 response regulator transcription factor Regulator
  DQN33_RS04955 (NCTC4674_01025) - 975028..977565 (-) 2538 WP_046390250.1 M1 family metallopeptidase -
  DQN33_RS04960 (NCTC4674_01026) phoU 977635..978288 (-) 654 WP_012658459.1 phosphate signaling complex protein PhoU -
  DQN33_RS04965 (NCTC4674_01027) pstB 978308..979066 (-) 759 WP_012658460.1 phosphate ABC transporter ATP-binding protein PstB -
  DQN33_RS04970 (NCTC4674_01028) pstB 979079..979882 (-) 804 WP_012658461.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25870.70 Da        Isoelectric Point: 4.3915

>NTDB_id=1140511 DQN33_RS04950 WP_012658457.1 974232..974906(-) (ciaR) [Streptococcus uberis strain NCTC4674]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKDIKTPVLIMTA
KETIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNNNLIRYGNIQVDTDRNMVTVNQENIELLGKEYELLIY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYISKIRKKLKSTDFATNLQTLRSVGYILKSND

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1140511 DQN33_RS04950 WP_012658457.1 974232..974906(-) (ciaR) [Streptococcus uberis strain NCTC4674]
ATGATAAAACTCTTATTGGTAGAGGATGATTTAAGCTTATCCAATTCCATCTTTGACTTTCTAGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGTGAAGAAGGACTATACGAGGCAGAAAGTGGTGTCTATGATCTTATTTTATTGGATCTGATGT
TACCAGAAAAAAATGGCTTTCAAGTATTGAAAGAATTAAGAGAAAAAGATATCAAAACACCGGTCTTAATCATGACCGCT
AAGGAAACCATTGATGATAAAGGTCATGGTTTTGAACTAGGAGCGGATGATTATTTAACGAAACCTTTTTATTTAGAAGA
GTTAAAAATGCGCATCCAAGCCTTGCTTAAAAGGTCTGGAAAGTTCAATAATAACCTTATTCGTTACGGGAACATTCAAG
TTGATACAGACCGTAATATGGTTACTGTTAACCAAGAAAACATTGAATTATTAGGTAAAGAATATGAACTTCTAATTTAT
TTTCTACAAAATCAAAATGTCATTCTTCCTAAATCTCAAATTTTTGATCGAATTTGGGGATTTGATAGTGACACAACCAT
CTCAGTAGTAGAGGTTTACATTTCTAAAATTCGAAAAAAACTAAAATCTACTGATTTTGCTACTAATTTACAAACACTAA
GAAGTGTTGGTTATATTTTGAAATCTAATGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4ES39

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

87.33

98.661

0.862
  ciaR Streptococcus pneumoniae Rx1

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae D39

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae R6

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae TIGR4

84.615

98.661

0.835
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment