Detailed information NTG1140448

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQM86_RS02205
• Genome accession: NZ_LS483407
• Coordinates: 401893..404046 (-)
• Length: 717 a.a.
• NCBI ID: WP_111674508.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC13744
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 396893..409046

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM86_RS02185 (NCTC13744_00429)	comE/blpR	398084..398833 (+)	750	WP_002992578.1	response regulator transcription factor	Regulator
DQM86_RS02190 (NCTC13744_00430)	-	398834..400168 (+)	1335	WP_111674506.1	sensor histidine kinase	-
DQM86_RS02195 (NCTC13744_00431)	-	400316..400441 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DQM86_RS02200 (NCTC13744_00432)	-	400518..401882 (-)	1365	WP_111674507.1	bacteriocin secretion accessory protein	-
DQM86_RS02205 (NCTC13744_00433)	comA/nlmT	401893..404046 (-)	2154	WP_111674508.1	peptide cleavage/export ABC transporter	Regulator
DQM86_RS02215	-	404499..405185 (+)	687	Protein_372	transposase	-
DQM86_RS02220 (NCTC13744_00435)	-	405373..405609 (+)	237	WP_111674509.1	Blp family class II bacteriocin	-
DQM86_RS02225 (NCTC13744_00436)	-	405634..405816 (+)	183	WP_002987564.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
DQM86_RS02230 (NCTC13744_00437)	-	406007..406692 (-)	686	Protein_375	transposase	-
DQM86_RS02235 (NCTC13744_00438)	-	407011..407238 (+)	228	WP_002992018.1	Blp family class II bacteriocin	-
DQM86_RS02240 (NCTC13744_00439)	-	407251..407451 (+)	201	WP_002985729.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
DQM86_RS09485	-	407812..407940 (+)	129	WP_002985724.1	hypothetical protein	-
DQM86_RS02255 (NCTC13744_00440)	-	407990..408271 (+)	282	WP_011054252.1	hypothetical protein	-
DQM86_RS02260 (NCTC13744_00441)	-	408465..408866 (+)	402	WP_023605036.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80573.48 Da
• Isoelectric Point: 7.0109

>NTDB_id=1140448 DQM86_RS02205 WP_111674508.1 401893..404046(-) (comA/nlmT) [Streptococcus pyogenes strain NCTC13744]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLINFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARTLLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=1140448 DQM86_RS02205 WP_111674508.1 401893..404046(-) (comA/nlmT) [Streptococcus pyogenes strain NCTC13744]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGGTTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAACTTTTTACCTCTT
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAATTACCCATGTCTTTCTTTGCAACACGTCGGACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACCAAACTTCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAATTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAACTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.867	99.721	0.727
comA	Streptococcus mitis NCTC 12261	67.511	99.163	0.669
comA	Streptococcus mitis SK321	67.089	99.163	0.665
comA	Streptococcus pneumoniae Rx1	67.089	99.163	0.665
comA	Streptococcus pneumoniae D39	67.089	99.163	0.665
comA	Streptococcus pneumoniae R6	67.089	99.163	0.665
comA	Streptococcus pneumoniae TIGR4	66.807	99.163	0.662
comA	Streptococcus gordonii str. Challis substr. CH1	66.014	99.721	0.658