Detailed information NTG1140426

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQM86_RS00330
• Genome accession: NZ_LS483407
• Coordinates: 52874..53785 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC13744
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47874..58785

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM86_RS00310 (NCTC13744_00062)	purE	48459..48950 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQM86_RS00315 (NCTC13744_00063)	purK	48937..50010 (+)	1074	WP_032460884.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQM86_RS09345 (NCTC13744_00064)	-	50012..50410 (+)	399	WP_227875639.1	hypothetical protein	-
DQM86_RS00320 (NCTC13744_00065)	-	50421..51431 (+)	1011	WP_227875640.1	hypothetical protein	-
DQM86_RS00325 (NCTC13744_00066)	purB	51451..52743 (+)	1293	WP_030127622.1	adenylosuccinate lyase	-
DQM86_RS00330 (NCTC13744_00067)	comR	52874..53785 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQM86_RS09550 (NCTC13744_00068)	comS	53869..53964 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQM86_RS00335 (NCTC13744_00069)	ruvB	54011..55009 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQM86_RS00340 (NCTC13744_00070)	-	55147..55584 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQM86_RS00345 (NCTC13744_00071)	-	55607..56008 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
DQM86_RS00350 (NCTC13744_00072)	-	56005..57780 (+)	1776	WP_002994672.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1140426 DQM86_RS00330 WP_002986681.1 52874..53785(+) (comR) [Streptococcus pyogenes strain NCTC13744]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1140426 DQM86_RS00330 WP_002986681.1 52874..53785(+) (comR) [Streptococcus pyogenes strain NCTC13744]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462