Detailed information NTG0114040

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: N507_RS05770
• Genome accession: NZ_CP006804
• Coordinates: 1202372..1204564 (-)
• Length: 730 a.a.
• NCBI ID: WP_005686870.1
• Uniprot ID: A0A1Z1XG57
• Organism: Lacticaseibacillus rhamnosus DSM 14870
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1205527..1206942	1202372..1204564	flank	963

Gene organization within MGE regions

Location: 1202372..1206942

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
N507_RS05770 (N507_1136)	comA	1202372..1204564 (-)	2193	WP_005686870.1	peptide cleavage/export ABC transporter	Regulator
N507_RS15845	-	1204840..1204992 (-)	153	WP_005686869.1	bacteriocin-like peptide, LSEI_2386 family	-
N507_RS05780 (N507_1137)	-	1205527..1206942 (+)	1416	WP_015764830.1	IS5-like element ISLrh2 family transposase	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81507.79 Da
• Isoelectric Point: 7.2454

>NTDB_id=114040 N507_RS05770 WP_005686870.1 1202372..1204564(-) (comA) [Lacticaseibacillus rhamnosus DSM 14870]
MVKYTPKLGQITYYKRFYTAQVDERDCGVAALNMLLKYNGSDYSLAHLRELAKTNQDGTTALGIVRAAEALAFETKPVQA
NMQLFDLEDVPYPFIAHVLKRGELLHYYVVFKATRTSILIGDPDPSVRMTWLSREVFEKEWSGVAIFIAPAPQYQPRKED
KGSLFAFVPMLAKQKGIIANIILAAVLITVISIVGSYFLQSIIDTYIPNAMRTTMGMIASGLLVAYLLQAVLTYGQNFLM
AVLGQRLAIDVILGYVRHLYELPMSFFSTRRTGEIVSRFADANKIIDALANTIMTLFLDVWIVLILGIVLGIQNGTLFLV
SLIAVPCYLVIVFAFQRPFDRLNQETMESNAILSSSIIEDLNGIETIKSLTGERVSYERVDREFLTYLKKSFSYTKADQL
QQAIKGLLKLALNVVVLWIGASLVIANRMSLGQMLTFNALLSYFTNPLESIINLQPKLQMARVANNRLNEVYLVESEFKE
QRHLTERHLIEGPIRVRDVSFKYGFGQDVLKNVNLEVPENAKYTIVGMSGSGKSTLAKLLVGFYPVDADKGTITFNGIPV
KDINLTTLRQYIEYVPQDPFIFSGTVLENLTLGSRSDVSEQDLTQACLAAEIAADIANLPQQWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGKIVEQGDHATLLAQ
DGYYARLVHE

Nucleotide

• Length: 2193 bp

>NTDB_id=114040 N507_RS05770 WP_005686870.1 1202372..1204564(-) (comA) [Lacticaseibacillus rhamnosus DSM 14870]
ATGGTTAAATACACCCCAAAACTAGGCCAGATCACCTACTACAAACGTTTCTACACCGCACAAGTTGACGAGCGTGACTG
TGGTGTGGCTGCGTTAAACATGCTGCTTAAATACAATGGGTCGGACTATTCGTTAGCCCACTTGCGCGAGTTAGCGAAGA
CAAATCAGGATGGCACGACGGCTTTGGGAATCGTTCGGGCCGCTGAAGCACTAGCGTTTGAGACGAAACCGGTGCAGGCG
AATATGCAGTTGTTTGATCTTGAGGATGTGCCTTATCCGTTTATTGCCCATGTGCTGAAGCGCGGTGAATTGCTTCATTA
CTATGTTGTTTTTAAAGCAACGCGCACGAGTATTCTGATTGGCGATCCTGACCCGTCAGTGCGCATGACCTGGCTTTCGC
GAGAGGTGTTTGAAAAAGAATGGTCGGGTGTGGCCATCTTTATTGCACCGGCGCCGCAGTATCAGCCGCGTAAGGAGGAC
AAAGGCAGTTTGTTTGCGTTTGTACCCATGCTGGCTAAGCAAAAAGGTATTATCGCGAACATTATTCTGGCCGCGGTATT
GATTACGGTCATTAGTATCGTTGGGTCGTATTTTTTGCAGTCTATTATTGATACGTATATACCGAATGCCATGCGGACGA
CGATGGGGATGATTGCTAGTGGCCTTTTGGTGGCTTACTTGCTGCAAGCTGTGTTGACTTATGGCCAGAATTTTTTGATG
GCGGTGTTGGGGCAGCGGCTTGCGATTGATGTCATTTTAGGGTATGTGCGCCACTTATATGAATTGCCGATGTCGTTTTT
TTCAACTCGGCGGACCGGAGAGATTGTGTCGCGGTTTGCGGATGCCAATAAAATTATTGACGCGCTGGCGAATACGATTA
TGACGTTGTTTTTGGATGTCTGGATTGTCCTAATATTAGGCATTGTTCTAGGGATCCAAAATGGGACTTTGTTTTTAGTG
TCATTGATTGCCGTGCCGTGTTATTTGGTGATTGTTTTTGCATTTCAGCGGCCGTTTGATCGGTTGAACCAAGAGACGAT
GGAAAGTAACGCAATCTTGAGTTCATCGATTATTGAAGATTTGAATGGCATTGAAACCATCAAGTCCCTGACCGGCGAAC
GAGTTAGCTATGAACGGGTTGATCGGGAATTTCTAACCTATCTGAAGAAATCGTTTAGTTACACCAAGGCAGATCAATTA
CAGCAAGCGATTAAAGGTCTGTTGAAGCTGGCGTTGAACGTTGTGGTGTTGTGGATTGGGGCAAGTTTGGTGATTGCCAA
TCGGATGAGCTTGGGGCAGATGCTGACCTTTAATGCACTGCTGTCATACTTTACGAATCCGCTTGAAAGCATCATCAACC
TACAGCCAAAGTTACAAATGGCGCGGGTTGCTAACAATCGCCTGAATGAAGTTTATCTGGTCGAATCGGAATTCAAAGAA
CAGCGGCACTTGACGGAGCGGCATTTAATCGAAGGTCCGATACGCGTTCGGGATGTCTCGTTTAAATATGGTTTTGGCCA
AGATGTATTGAAAAACGTCAACCTTGAAGTGCCGGAAAATGCTAAATATACCATTGTTGGCATGAGCGGTTCTGGTAAGT
CGACATTAGCAAAATTATTAGTTGGCTTTTACCCGGTTGATGCCGATAAAGGAACCATCACGTTTAATGGCATTCCGGTC
AAAGACATTAACCTGACAACATTACGGCAATATATTGAATATGTACCTCAGGATCCGTTTATTTTTTCGGGCACGGTGTT
GGAGAATTTGACGTTAGGTAGCCGTTCGGATGTTTCGGAACAAGATTTGACGCAGGCGTGTTTGGCTGCGGAAATTGCCG
CAGACATCGCAAACTTACCGCAGCAGTGGCAGACCAAATTGTCAGAAAGCGGCAGTATTTTATCAGGCGGTCAGAAGCAG
CGGCTGGCGATTGCACGGGCCTTGTTGTCACCGGCAAAAGTACTGATTTTTGACGAATCGACCAGCAGTCTGGATACCAT
TACAGAGCGAAAAATTGTCGATCGCTTGCTGGCAATGACGGATCGGACCATTATTTTTGTTGCCCATCGCTTAACTATTG
CGGCTAAAACCGAACAAATTGTGGTGATGGATCATGGCAAAATTGTGGAACAAGGTGACCATGCAACGTTGTTAGCCCAA
GACGGTTATTACGCGCGCCTGGTTCATGAGTGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (18-152)

• ABC transporter (ABC_tran) (510-662)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

3D structure

• AlphaFold DB: A0A1Z1XG57

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus pneumoniae D39	58.182	97.945	0.57
comA	Streptococcus pneumoniae R6	58.182	97.945	0.57
comA	Streptococcus pneumoniae Rx1	58.182	97.945	0.57
comA	Streptococcus pneumoniae TIGR4	57.762	97.945	0.566
comA	Streptococcus mitis NCTC 12261	57.762	97.945	0.566
comA	Streptococcus mitis SK321	57.622	97.945	0.564
comA	Streptococcus gordonii str. Challis substr. CH1	56.606	98.493	0.558
comA/nlmT	Streptococcus mutans UA159	53.686	98.493	0.529