Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQM80_RS01250 Genome accession   NZ_LS483399
Coordinates   231628..232389 (+) Length   253 a.a.
NCBI ID   WP_011106593.1    Uniprot ID   A0A5S4TK55
Organism   Streptococcus pyogenes strain NCTC8227     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 226628..237389
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM80_RS01235 (NCTC8227_00245) - 226886..228454 (-) 1569 WP_002991130.1 ABC transporter substrate-binding protein/permease -
  DQM80_RS01240 (NCTC8227_00246) - 228652..230577 (+) 1926 WP_085614041.1 DUF2207 domain-containing protein -
  DQM80_RS01245 (NCTC8227_00247) - 230643..231482 (+) 840 WP_111677036.1 undecaprenyl-diphosphate phosphatase -
  DQM80_RS01250 (NCTC8227_00248) mecA 231628..232389 (+) 762 WP_011106593.1 adaptor protein MecA Regulator
  DQM80_RS01255 (NCTC8227_00249) - 232396..233565 (+) 1170 WP_011184169.1 glycosyltransferase family 4 protein -
  DQM80_RS01260 (NCTC8227_00250) sufC 233687..234457 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  DQM80_RS01265 (NCTC8227_00251) sufD 234552..235814 (+) 1263 WP_011017331.1 Fe-S cluster assembly protein SufD -
  DQM80_RS01270 (NCTC8227_00252) - 235845..237071 (+) 1227 WP_002986020.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.68 Da        Isoelectric Point: 4.1282

>NTDB_id=1140213 DQM80_RS01250 WP_011106593.1 231628..232389(+) (mecA) [Streptococcus pyogenes strain NCTC8227]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEQIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=1140213 DQM80_RS01250 WP_011106593.1 231628..232389(+) (mecA) [Streptococcus pyogenes strain NCTC8227]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAACAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TK55

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.627

100

0.49
  mecA Streptococcus pneumoniae D39

48.627

100

0.49
  mecA Streptococcus pneumoniae R6

48.627

100

0.49
  mecA Streptococcus pneumoniae TIGR4

48.627

100

0.49

Multiple sequence alignment