Detailed information NTG1140204

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQM80_RS00260
• Genome accession: NZ_LS483399
• Coordinates: 47034..47945 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8227
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42034..52945

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM80_RS00240 (NCTC8227_00049)	purE	42329..42820 (+)	492	WP_111701709.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQM80_RS00245 (NCTC8227_00050)	purK	42807..43880 (+)	1074	WP_172452960.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQM80_RS00250 (NCTC8227_00051)	-	43901..45241 (+)	1341	WP_111701713.1	hypothetical protein	-
DQM80_RS00255 (NCTC8227_00052)	purB	45610..46902 (+)	1293	WP_002987723.1	adenylosuccinate lyase	-
DQM80_RS00260 (NCTC8227_00053)	comR	47034..47945 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQM80_RS09640 (NCTC8227_00054)	comS	48029..48124 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQM80_RS00265 (NCTC8227_00055)	ruvB	48171..49169 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
DQM80_RS00270 (NCTC8227_00056)	-	49307..49744 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQM80_RS00275 (NCTC8227_00057)	-	49767..50168 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
DQM80_RS00280 (NCTC8227_00058)	-	50165..51940 (+)	1776	WP_002986669.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1140204 DQM80_RS00260 WP_002986681.1 47034..47945(+) (comR) [Streptococcus pyogenes strain NCTC8227]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1140204 DQM80_RS00260 WP_002986681.1 47034..47945(+) (comR) [Streptococcus pyogenes strain NCTC8227]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462