Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQM95_RS05250 Genome accession   NZ_LS483397
Coordinates   985492..986166 (-) Length   224 a.a.
NCBI ID   WP_012658457.1    Uniprot ID   A0A2X4ES39
Organism   Streptococcus uberis strain NCTC3858     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 980492..991166
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM95_RS05225 (NCTC3858_01069) - 980762..982039 (-) 1278 WP_012658452.1 pyrimidine-nucleoside phosphorylase -
  DQM95_RS05230 (NCTC3858_01070) - 982036..982626 (-) 591 WP_012658453.1 class I SAM-dependent methyltransferase -
  DQM95_RS05235 (NCTC3858_01071) coaA 982890..983810 (+) 921 WP_037592124.1 type I pantothenate kinase -
  DQM95_RS05240 (NCTC3858_01072) rpsT 983870..984112 (+) 243 WP_160463058.1 30S ribosomal protein S20 -
  DQM95_RS05245 (NCTC3858_01073) ciaH 984189..985499 (-) 1311 WP_037592122.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DQM95_RS05250 (NCTC3858_01074) ciaR 985492..986166 (-) 675 WP_012658457.1 response regulator transcription factor Regulator
  DQM95_RS05255 (NCTC3858_01075) - 986288..988825 (-) 2538 WP_037592121.1 M1 family metallopeptidase -
  DQM95_RS05260 (NCTC3858_01076) phoU 988896..989549 (-) 654 WP_012658459.1 phosphate signaling complex protein PhoU -
  DQM95_RS05265 (NCTC3858_01077) pstB 989569..990327 (-) 759 WP_012658460.1 phosphate ABC transporter ATP-binding protein PstB -
  DQM95_RS05270 (NCTC3858_01078) pstB 990340..991143 (-) 804 WP_012658461.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25870.70 Da        Isoelectric Point: 4.3915

>NTDB_id=1140169 DQM95_RS05250 WP_012658457.1 985492..986166(-) (ciaR) [Streptococcus uberis strain NCTC3858]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKDIKTPVLIMTA
KETIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNNNLIRYGNIQVDTDRNMVTVNQENIELLGKEYELLIY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYISKIRKKLKSTDFATNLQTLRSVGYILKSND

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1140169 DQM95_RS05250 WP_012658457.1 985492..986166(-) (ciaR) [Streptococcus uberis strain NCTC3858]
ATGATAAAACTCTTATTGGTAGAGGATGATTTAAGCTTATCCAATTCCATCTTTGACTTTCTAGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGTGAAGAAGGACTATACGAGGCAGAAAGTGGTGTCTATGATCTTATTTTATTGGATCTGATGT
TACCAGAAAAAAATGGCTTTCAAGTATTGAAAGAATTAAGAGAAAAAGATATCAAAACACCGGTCTTAATCATGACCGCT
AAGGAAACCATTGATGATAAAGGTCATGGTTTTGAACTAGGAGCGGATGATTATTTAACGAAACCTTTTTATTTAGAAGA
GTTAAAAATGCGCATCCAAGCCTTGCTTAAAAGGTCTGGAAAGTTCAATAATAACCTTATTCGTTACGGGAACATTCAAG
TTGATACAGACCGTAATATGGTTACTGTTAACCAAGAAAACATTGAATTATTAGGTAAAGAATATGAACTTCTGATTTAT
TTTCTACAAAATCAAAATGTCATTCTTCCTAAATCTCAAATTTTTGATCGAATTTGGGGATTTGATAGTGACACAACCAT
CTCAGTAGTAGAGGTTTACATTTCTAAAATTCGAAAAAAACTAAAATCTACTGATTTTGCCACTAATTTACAAACACTAA
GAAGTGTTGGTTATATTTTGAAATCTAATGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4ES39

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

87.33

98.661

0.862
  ciaR Streptococcus pneumoniae Rx1

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae D39

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae R6

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae TIGR4

84.615

98.661

0.835
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment