Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQM95_RS02225 Genome accession   NZ_LS483397
Coordinates   389048..389806 (+) Length   252 a.a.
NCBI ID   WP_012657878.1    Uniprot ID   B9DTL0
Organism   Streptococcus uberis strain NCTC3858     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 384048..394806
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM95_RS02210 (NCTC3858_00449) - 384371..385921 (-) 1551 WP_037593540.1 ABC transporter substrate-binding protein/permease -
  DQM95_RS02215 (NCTC3858_00450) - 386123..388024 (+) 1902 WP_046393291.1 DUF2207 domain-containing protein -
  DQM95_RS02220 (NCTC3858_00451) - 388094..388933 (+) 840 WP_012657877.1 undecaprenyl-diphosphate phosphatase -
  DQM95_RS02225 (NCTC3858_00452) mecA 389048..389806 (+) 759 WP_012657878.1 adaptor protein MecA Regulator
  DQM95_RS02230 (NCTC3858_00453) - 389813..390970 (+) 1158 WP_037593539.1 glycosyltransferase family 4 protein -
  DQM95_RS02235 (NCTC3858_00454) - 391313..391636 (+) 324 WP_037593538.1 hypothetical protein -
  DQM95_RS02240 (NCTC3858_00455) sufC 391969..392739 (+) 771 WP_037593536.1 Fe-S cluster assembly ATPase SufC -
  DQM95_RS02245 (NCTC3858_00456) sufD 392844..394115 (+) 1272 WP_037593535.1 Fe-S cluster assembly protein SufD -

Sequence

Protein


Download         Length: 252 a.a.        Molecular weight: 29392.19 Da        Isoelectric Point: 4.1676

>NTDB_id=1140151 DQM95_RS02225 WP_012657878.1 389048..389806(+) (mecA) [Streptococcus uberis strain NCTC3858]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSDL
NKEINFDDLADLGDVSQMTPEDFFKTIEKSMIEKGDVNAHEKLEKIEEMMEEAVDAVMTQNAEEQKEEESPFEPLDYVHY
VLDFMTIQDAITFSKTVTFPIEASELYKSSDRYHMTILLDIQNQPSYYANVMYARLIEHALPGSKTRAYLQEHAHQLLED
HAVTELQKVELV

Nucleotide


Download         Length: 759 bp        

>NTDB_id=1140151 DQM95_RS02225 WP_012657878.1 389048..389806(+) (mecA) [Streptococcus uberis strain NCTC3858]
ATGGAAATGAAACAAATCAGCGAAACAACGCTAAAAATCACTATTAGTATGGATGATCTGGAAGAAAGAGGAATGGAGTT
AAAAGACTTCTTAATCCCTCAAGAAAAAACGGAAGAATTCTTTTACACTGTCATGGATGAGCTAGACTTACCTGATAATT
TTAAAGACAGTGGTATGTTAAGTTTCCGAGTTACTCCAAGAAAGGACCGTTTGGATGTCTTTGTCACCAAATCAGATTTG
AATAAAGAAATTAATTTTGATGATTTGGCAGACTTGGGAGATGTTTCTCAAATGACACCTGAAGACTTCTTCAAAACAAT
TGAGAAGAGTATGATTGAAAAAGGTGATGTTAACGCTCATGAGAAACTCGAGAAAATTGAAGAAATGATGGAAGAAGCAG
TGGATGCTGTTATGACGCAAAATGCTGAAGAGCAAAAGGAAGAAGAGTCACCTTTTGAACCTCTAGATTATGTGCATTAC
GTTTTGGATTTCATGACCATTCAAGATGCCATTACCTTTTCTAAAACAGTGACCTTCCCGATAGAAGCTTCTGAATTATA
TAAAAGTTCTGACCGATATCACATGACCATTTTATTGGATATTCAAAACCAACCTTCTTATTATGCCAATGTCATGTATG
CTAGATTAATTGAGCATGCACTCCCAGGTAGTAAGACTAGAGCTTACTTGCAGGAACATGCCCATCAATTACTGGAAGAT
CATGCAGTAACAGAATTACAAAAAGTAGAGTTGGTGTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-246)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B9DTL0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.855

98.81

0.631
  mecA Streptococcus thermophilus LMD-9

59.274

98.413

0.583
  mecA Streptococcus thermophilus LMG 18311

58.871

98.413

0.579
  mecA Streptococcus pneumoniae Rx1

49.213

100

0.496
  mecA Streptococcus pneumoniae D39

49.213

100

0.496
  mecA Streptococcus pneumoniae R6

49.213

100

0.496
  mecA Streptococcus pneumoniae TIGR4

49.213

100

0.496

Multiple sequence alignment