Detailed information
Bioinformatically predicted
Overview
| Name | comYB | Type | Machinery gene |
| Locus tag | DQM95_RS00770 | Genome accession | NZ_LS483397 |
| Coordinates | 124648..125682 (+) | Length | 344 a.a. |
| NCBI ID | WP_408646205.1 | Uniprot ID | - |
| Organism | Streptococcus uberis strain NCTC3858 | ||
| Function | dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 125763..181096 | 124648..125682 | flank | 81 |
Gene organization within MGE regions
Location: 124648..181096
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQM95_RS00770 (NCTC3858_00157) | comYB | 124648..125682 (+) | 1035 | WP_408646205.1 | competence type IV pilus assembly protein ComGB | Machinery gene |
| DQM95_RS00780 (NCTC3858_00159) | - | 125763..127208 (-) | 1446 | WP_037592992.1 | recombinase family protein | - |
| DQM95_RS00785 (NCTC3858_00160) | - | 127358..127807 (-) | 450 | WP_037592991.1 | Ltp family lipoprotein | - |
| DQM95_RS00790 (NCTC3858_00161) | - | 127860..128237 (-) | 378 | WP_037593023.1 | ImmA/IrrE family metallo-endopeptidase | - |
| DQM95_RS00795 (NCTC3858_00162) | - | 128221..128583 (-) | 363 | WP_037592990.1 | helix-turn-helix domain-containing protein | - |
| DQM95_RS00800 (NCTC3858_00163) | - | 128774..128974 (+) | 201 | WP_037592989.1 | helix-turn-helix transcriptional regulator | - |
| DQM95_RS00805 (NCTC3858_00164) | - | 129021..129746 (+) | 726 | WP_037592987.1 | phage antirepressor KilAC domain-containing protein | - |
| DQM95_RS00810 (NCTC3858_00165) | - | 129758..130099 (+) | 342 | WP_037592986.1 | hypothetical protein | - |
| DQM95_RS00815 (NCTC3858_00166) | - | 130100..130312 (-) | 213 | WP_037592984.1 | hypothetical protein | - |
| DQM95_RS00820 | - | 130462..130647 (+) | 186 | WP_037592983.1 | helix-turn-helix transcriptional regulator | - |
| DQM95_RS10020 (NCTC3858_00167) | - | 130710..130868 (+) | 159 | WP_170123115.1 | BOW99_gp33 family protein | - |
| DQM95_RS00830 (NCTC3858_00168) | - | 131395..131676 (+) | 282 | WP_037592981.1 | hypothetical protein | - |
| DQM95_RS00835 (NCTC3858_00169) | - | 131676..131936 (+) | 261 | WP_037592980.1 | hypothetical protein | - |
| DQM95_RS10145 (NCTC3858_00170) | - | 131949..132080 (+) | 132 | WP_269460017.1 | hypothetical protein | - |
| DQM95_RS00840 (NCTC3858_00171) | - | 132084..132263 (+) | 180 | WP_037592979.1 | hypothetical protein | - |
| DQM95_RS00845 (NCTC3858_00172) | bet | 132260..133033 (+) | 774 | WP_037592978.1 | phage recombination protein Bet | - |
| DQM95_RS00850 (NCTC3858_00173) | - | 133044..134072 (+) | 1029 | WP_037592977.1 | DUF1351 domain-containing protein | - |
| DQM95_RS00855 (NCTC3858_00174) | - | 134075..134344 (+) | 270 | WP_037592976.1 | hypothetical protein | - |
| DQM95_RS00860 (NCTC3858_00175) | - | 134354..134677 (+) | 324 | WP_037592975.1 | hypothetical protein | - |
| DQM95_RS00865 (NCTC3858_00176) | - | 134674..134853 (+) | 180 | WP_037592974.1 | hypothetical protein | - |
| DQM95_RS00875 (NCTC3858_00177) | - | 135323..135664 (+) | 342 | WP_037592972.1 | hypothetical protein | - |
| DQM95_RS00880 (NCTC3858_00178) | - | 135664..136092 (+) | 429 | WP_037592971.1 | RusA family crossover junction endodeoxyribonuclease | - |
| DQM95_RS00885 (NCTC3858_00179) | - | 136083..136397 (+) | 315 | WP_037592970.1 | DUF1372 family protein | - |
| DQM95_RS00890 (NCTC3858_00180) | - | 136394..136846 (+) | 453 | WP_037592969.1 | YopX family protein | - |
| DQM95_RS00895 (NCTC3858_00181) | - | 136827..137072 (+) | 246 | WP_037592968.1 | hypothetical protein | - |
| DQM95_RS00900 (NCTC3858_00182) | - | 137069..137383 (+) | 315 | WP_037592967.1 | hypothetical protein | - |
| DQM95_RS00905 (NCTC3858_00183) | - | 137458..137874 (+) | 417 | WP_037592964.1 | DUF1492 domain-containing protein | - |
| DQM95_RS00910 (NCTC3858_00184) | terS | 138034..138765 (+) | 732 | WP_037592962.1 | phage terminase small subunit | - |
| DQM95_RS00915 (NCTC3858_00185) | - | 138734..140032 (+) | 1299 | WP_037592960.1 | PBSX family phage terminase large subunit | - |
| DQM95_RS00920 (NCTC3858_00186) | - | 140044..141555 (+) | 1512 | WP_331813043.1 | phage portal protein | - |
| DQM95_RS00925 (NCTC3858_00187) | - | 141560..143182 (+) | 1623 | WP_037592958.1 | phage minor capsid protein | - |
| DQM95_RS00930 (NCTC3858_00188) | - | 143179..143370 (+) | 192 | WP_037592956.1 | hypothetical protein | - |
| DQM95_RS00935 (NCTC3858_00189) | - | 143421..143693 (+) | 273 | WP_037592949.1 | hypothetical protein | - |
| DQM95_RS00940 (NCTC3858_00190) | - | 143861..144424 (+) | 564 | WP_037592944.1 | phage scaffolding protein | - |
| DQM95_RS00945 (NCTC3858_00191) | - | 144445..145314 (+) | 870 | WP_037592941.1 | hypothetical protein | - |
| DQM95_RS10025 (NCTC3858_00192) | - | 145328..145486 (+) | 159 | WP_000032859.1 | hypothetical protein | - |
| DQM95_RS00950 (NCTC3858_00193) | - | 145492..145692 (+) | 201 | WP_001051385.1 | hypothetical protein | - |
| DQM95_RS00955 (NCTC3858_00194) | - | 145707..146117 (+) | 411 | WP_111685886.1 | hypothetical protein | - |
| DQM95_RS00960 (NCTC3858_00195) | - | 146104..146445 (+) | 342 | WP_037592938.1 | putative minor capsid protein | - |
| DQM95_RS00965 (NCTC3858_00196) | - | 146445..146807 (+) | 363 | WP_037592937.1 | minor capsid protein | - |
| DQM95_RS00970 (NCTC3858_00197) | - | 146804..147205 (+) | 402 | WP_111685887.1 | minor capsid protein | - |
| DQM95_RS00975 (NCTC3858_00198) | - | 147206..147667 (+) | 462 | WP_037592936.1 | phage tail tube protein | - |
| DQM95_RS00980 (NCTC3858_00199) | - | 147730..148098 (+) | 369 | WP_006739703.1 | hypothetical protein | - |
| DQM95_RS00985 (NCTC3858_00200) | - | 148100..148699 (+) | 600 | WP_037592934.1 | Gp15 family bacteriophage protein | - |
| DQM95_RS00990 (NCTC3858_00201) | - | 148715..152092 (+) | 3378 | WP_037592930.1 | tape measure protein | - |
| DQM95_RS00995 (NCTC3858_00202) | - | 152089..153531 (+) | 1443 | WP_111685888.1 | distal tail protein Dit | - |
| DQM95_RS01000 (NCTC3858_00203) | - | 153531..156311 (+) | 2781 | WP_037592928.1 | phage tail spike protein | - |
| DQM95_RS01005 (NCTC3858_00204) | - | 156325..158334 (+) | 2010 | WP_037592924.1 | DUF859 domain-containing protein | - |
| DQM95_RS01010 (NCTC3858_00205) | - | 158347..158745 (+) | 399 | WP_037592923.1 | DUF1366 domain-containing protein | - |
| DQM95_RS10030 (NCTC3858_00206) | - | 158808..158966 (+) | 159 | WP_170123116.1 | hypothetical protein | - |
| DQM95_RS01015 (NCTC3858_00207) | - | 158979..159449 (+) | 471 | WP_111685889.1 | phage holin family protein | - |
| DQM95_RS10190 (NCTC3858_00208) | - | 159451..160164 (+) | 714 | WP_037592922.1 | peptidoglycan amidohydrolase family protein | - |
| DQM95_RS01030 (NCTC3858_00211) | comYC | 161081..161347 (+) | 267 | WP_037592920.1 | competence type IV pilus major pilin ComGC | Machinery gene |
| DQM95_RS01035 (NCTC3858_00212) | comGD | 161298..161735 (+) | 438 | WP_111685890.1 | competence type IV pilus minor pilin ComGD | - |
| DQM95_RS01040 (NCTC3858_00213) | comGE | 161707..162006 (+) | 300 | WP_111685891.1 | competence type IV pilus minor pilin ComGE | - |
| DQM95_RS01045 (NCTC3858_00214) | comGF | 161966..162421 (+) | 456 | WP_037592918.1 | competence type IV pilus minor pilin ComGF | - |
| DQM95_RS01050 (NCTC3858_00215) | comGG | 162399..162758 (+) | 360 | WP_037592916.1 | competence type IV pilus minor pilin ComGG | - |
| DQM95_RS01055 (NCTC3858_00216) | comYH | 162803..163759 (+) | 957 | WP_037592915.1 | class I SAM-dependent methyltransferase | Machinery gene |
| DQM95_RS01060 (NCTC3858_00217) | - | 163815..165005 (+) | 1191 | WP_037592914.1 | acetate kinase | - |
| DQM95_RS01065 (NCTC3858_00218) | - | 165123..165326 (+) | 204 | WP_012657682.1 | helix-turn-helix transcriptional regulator | - |
| DQM95_RS01070 | - | 165328..165780 (+) | 453 | WP_037592912.1 | hypothetical protein | - |
| DQM95_RS01075 (NCTC3858_00220) | - | 165789..166442 (+) | 654 | WP_012657684.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DQM95_RS01080 (NCTC3858_00221) | proC | 166468..167238 (-) | 771 | WP_111685892.1 | pyrroline-5-carboxylate reductase | - |
| DQM95_RS01085 (NCTC3858_00222) | pepA | 167260..168324 (-) | 1065 | WP_111686022.1 | glutamyl aminopeptidase | - |
| DQM95_RS01090 (NCTC3858_00223) | - | 168473..168760 (+) | 288 | WP_037592911.1 | DUF4651 domain-containing protein | - |
| DQM95_RS01095 (NCTC3858_00224) | - | 168753..169067 (+) | 315 | WP_037592909.1 | thioredoxin family protein | - |
| DQM95_RS01100 (NCTC3858_00225) | ytpR | 169086..169712 (+) | 627 | WP_037592907.1 | YtpR family tRNA-binding protein | - |
| DQM95_RS01105 (NCTC3858_00226) | - | 169906..173715 (+) | 3810 | WP_111685893.1 | GH32 C-terminal domain-containing protein | - |
| DQM95_RS01110 (NCTC3858_00227) | ssbA | 173879..174277 (+) | 399 | WP_012657691.1 | single-stranded DNA-binding protein | Machinery gene |
| DQM95_RS01115 (NCTC3858_00228) | - | 174769..175728 (+) | 960 | WP_111685894.1 | ABC transporter substrate-binding protein | - |
| DQM95_RS01120 (NCTC3858_00229) | - | 175745..176707 (+) | 963 | WP_037592900.1 | ABC transporter substrate-binding protein | - |
| DQM95_RS01125 (NCTC3858_00230) | - | 176744..177628 (+) | 885 | WP_037592899.1 | ABC transporter permease | - |
| DQM95_RS01130 (NCTC3858_00231) | - | 177637..178440 (+) | 804 | WP_046388461.1 | ABC transporter ATP-binding protein | - |
| DQM95_RS01135 (NCTC3858_00232) | - | 178733..180787 (+) | 2055 | WP_037592898.1 | transcription antiterminator | - |
| DQM95_RS01140 (NCTC3858_00233) | - | 180788..181096 (+) | 309 | WP_037592897.1 | PTS sugar transporter subunit IIB | - |
Sequence
Protein
Download Length: 344 a.a. Molecular weight: 39861.54 Da Isoelectric Point: 9.5535
>NTDB_id=1140145 DQM95_RS00770 WP_408646205.1 124648..125682(+) (comYB) [Streptococcus uberis strain NCTC3858]
MSNFLNKDISITKKPSWKKLKAKQQYQLIKLLHNLSLSGFNLNEMVSFLEKAHLLEDHFVQRMKIDLMNGRDISEMMAHL
GFSDALVTQLSLAEVHGNTTNCLAKIEDYMAQSNRIRQKTIEVITYPMVLMTFLIVILMGLRHYLLPQIGEENQLTHFLN
LFPTVLLLTFFAMIAVVIFLRLCWRKKSQLKQLLVYSKIPLLSAVLQLYLTAYYAREWGNLIAQGVELATILQLMQKEKS
VLMREMGSTMEKALLEGKSFDQSVGIFPFFKRELSLMIEYGEIKGKLGQELDIYAQVSWENYFRKLRQMTQWLQPLIFIL
VAIIIVMIYAAMLLPMYQTIGGEI
MSNFLNKDISITKKPSWKKLKAKQQYQLIKLLHNLSLSGFNLNEMVSFLEKAHLLEDHFVQRMKIDLMNGRDISEMMAHL
GFSDALVTQLSLAEVHGNTTNCLAKIEDYMAQSNRIRQKTIEVITYPMVLMTFLIVILMGLRHYLLPQIGEENQLTHFLN
LFPTVLLLTFFAMIAVVIFLRLCWRKKSQLKQLLVYSKIPLLSAVLQLYLTAYYAREWGNLIAQGVELATILQLMQKEKS
VLMREMGSTMEKALLEGKSFDQSVGIFPFFKRELSLMIEYGEIKGKLGQELDIYAQVSWENYFRKLRQMTQWLQPLIFIL
VAIIIVMIYAAMLLPMYQTIGGEI
Nucleotide
Download Length: 1035 bp
>NTDB_id=1140145 DQM95_RS00770 WP_408646205.1 124648..125682(+) (comYB) [Streptococcus uberis strain NCTC3858]
TTGAGCAACTTCTTAAACAAGGATATATCGATAACGAAAAAGCCAAGTTGGAAAAAATTAAAGGCTAAACAACAATACCA
GCTGATCAAATTATTACATAATCTTAGTCTAAGTGGGTTTAACTTGAACGAAATGGTATCTTTTCTTGAGAAGGCACATC
TCTTAGAGGATCATTTTGTTCAAAGAATGAAAATAGATTTAATGAATGGACGAGATATTTCGGAAATGATGGCCCATCTT
GGATTCTCAGATGCATTGGTAACACAGCTAAGTTTAGCTGAAGTCCATGGGAACACCACCAACTGTTTAGCAAAGATAGA
AGATTATATGGCTCAATCCAATCGGATTAGACAAAAAACCATTGAAGTCATTACTTATCCTATGGTCTTGATGACCTTCT
TAATCGTGATTTTGATGGGCTTACGCCATTATTTACTTCCGCAAATAGGAGAGGAAAACCAGCTAACACATTTTCTAAAT
TTATTTCCGACAGTATTGCTTTTGACTTTCTTTGCTATGATTGCGGTAGTAATCTTCCTCAGACTCTGCTGGCGAAAAAA
ATCCCAGTTAAAACAATTATTAGTGTATAGTAAAATCCCTCTTTTATCAGCTGTTTTACAATTGTATCTAACTGCCTATT
ATGCGAGAGAGTGGGGCAATCTTATTGCACAAGGTGTTGAACTAGCAACTATTTTGCAACTGATGCAAAAGGAAAAATCC
GTATTGATGCGGGAAATGGGTTCAACAATGGAAAAAGCTTTGTTGGAAGGGAAATCTTTTGACCAGTCTGTGGGCATCTT
CCCATTTTTTAAAAGGGAATTGAGCTTAATGATTGAATATGGAGAAATCAAAGGAAAACTCGGTCAAGAGTTAGACATTT
ATGCACAAGTCAGTTGGGAAAACTATTTTAGAAAGTTACGACAGATGACTCAATGGTTACAACCCCTCATTTTCATACTT
GTAGCCATTATAATCGTTATGATTTATGCGGCAATGTTATTGCCAATGTATCAAACCATCGGAGGTGAAATATAA
TTGAGCAACTTCTTAAACAAGGATATATCGATAACGAAAAAGCCAAGTTGGAAAAAATTAAAGGCTAAACAACAATACCA
GCTGATCAAATTATTACATAATCTTAGTCTAAGTGGGTTTAACTTGAACGAAATGGTATCTTTTCTTGAGAAGGCACATC
TCTTAGAGGATCATTTTGTTCAAAGAATGAAAATAGATTTAATGAATGGACGAGATATTTCGGAAATGATGGCCCATCTT
GGATTCTCAGATGCATTGGTAACACAGCTAAGTTTAGCTGAAGTCCATGGGAACACCACCAACTGTTTAGCAAAGATAGA
AGATTATATGGCTCAATCCAATCGGATTAGACAAAAAACCATTGAAGTCATTACTTATCCTATGGTCTTGATGACCTTCT
TAATCGTGATTTTGATGGGCTTACGCCATTATTTACTTCCGCAAATAGGAGAGGAAAACCAGCTAACACATTTTCTAAAT
TTATTTCCGACAGTATTGCTTTTGACTTTCTTTGCTATGATTGCGGTAGTAATCTTCCTCAGACTCTGCTGGCGAAAAAA
ATCCCAGTTAAAACAATTATTAGTGTATAGTAAAATCCCTCTTTTATCAGCTGTTTTACAATTGTATCTAACTGCCTATT
ATGCGAGAGAGTGGGGCAATCTTATTGCACAAGGTGTTGAACTAGCAACTATTTTGCAACTGATGCAAAAGGAAAAATCC
GTATTGATGCGGGAAATGGGTTCAACAATGGAAAAAGCTTTGTTGGAAGGGAAATCTTTTGACCAGTCTGTGGGCATCTT
CCCATTTTTTAAAAGGGAATTGAGCTTAATGATTGAATATGGAGAAATCAAAGGAAAACTCGGTCAAGAGTTAGACATTT
ATGCACAAGTCAGTTGGGAAAACTATTTTAGAAAGTTACGACAGATGACTCAATGGTTACAACCCCTCATTTTCATACTT
GTAGCCATTATAATCGTTATGATTTATGCGGCAATGTTATTGCCAATGTATCAAACCATCGGAGGTGAAATATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comYB | Streptococcus mutans UA159 |
53.254 |
98.256 |
0.523 |
| comYB | Streptococcus mutans UA140 |
53.254 |
98.256 |
0.523 |
| comYB | Streptococcus gordonii str. Challis substr. CH1 |
47.353 |
98.837 |
0.468 |
| comGB/cglB | Streptococcus mitis NCTC 12261 |
47.305 |
97.093 |
0.459 |
| comGB | Lactococcus lactis subsp. cremoris KW2 |
45.161 |
99.128 |
0.448 |
| comGB/cglB | Streptococcus mitis SK321 |
45.946 |
96.802 |
0.445 |
| comGB/cglB | Streptococcus pneumoniae Rx1 |
44.745 |
96.802 |
0.433 |
| comGB/cglB | Streptococcus pneumoniae D39 |
44.745 |
96.802 |
0.433 |
| comGB/cglB | Streptococcus pneumoniae R6 |
44.745 |
96.802 |
0.433 |
| comGB/cglB | Streptococcus pneumoniae TIGR4 |
44.745 |
96.802 |
0.433 |