Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   DQM65_RS03340 Genome accession   NZ_LS483392
Coordinates   648582..649925 (-) Length   447 a.a.
NCBI ID   WP_111691236.1    Uniprot ID   -
Organism   Haemophilus influenzae strain NCTC11931     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 643582..654925
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM65_RS03310 (NCTC11931_00662) - 644418..644690 (-) 273 WP_014550417.1 HU family DNA-binding protein -
  DQM65_RS03315 (NCTC11931_00663) - 644829..645419 (-) 591 WP_111691234.1 YjaG family protein -
  DQM65_RS03320 (NCTC11931_00664) nudC 645455..646249 (-) 795 WP_042594793.1 NAD(+) diphosphatase -
  DQM65_RS03325 (NCTC11931_00665) nfuA 646317..646913 (-) 597 WP_050847361.1 Fe-S biogenesis protein NfuA -
  DQM65_RS03330 (NCTC11931_00666) - 646989..647675 (-) 687 WP_111691235.1 ComF family protein -
  DQM65_RS03335 (NCTC11931_00667) tnpA 648130..648585 (-) 456 WP_005652127.1 IS200/IS605 family transposase -
  DQM65_RS03340 (NCTC11931_00668) comE 648582..649925 (-) 1344 WP_111691236.1 type IV pilus secretin PilQ family protein Machinery gene
  DQM65_RS03345 (NCTC11931_00669) comD 649935..650348 (-) 414 WP_111691237.1 pilus assembly protein PilP Machinery gene
  DQM65_RS03350 (NCTC11931_00670) comC 650345..650866 (-) 522 WP_111691238.1 competence protein ComC Machinery gene
  DQM65_RS03355 (NCTC11931_00671) comB 650863..651369 (-) 507 WP_111691239.1 competence protein B Machinery gene
  DQM65_RS03360 (NCTC11931_00672) comA 651370..652167 (-) 798 WP_111691240.1 pilus assembly protein PilM Machinery gene
  DQM65_RS03365 (NCTC11931_00673) - 652266..654860 (+) 2595 WP_111691241.1 penicillin-binding protein 1A -

Sequence

Protein


Download         Length: 447 a.a.        Molecular weight: 49482.64 Da        Isoelectric Point: 6.7040

>NTDB_id=1140031 DQM65_RS03340 WP_111691236.1 648582..649925(-) (comE) [Haemophilus influenzae strain NCTC11931]
MNKYLLKCGYFLVCFCLPLIVFANSKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVMDEALESNISLRLDNIDMPRLLQ
IIAKSKHLRLNKDDDIYYLNGGQSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPTGSITFDDRSN
LLVIQDDPRSVQNIKKLISEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLVGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKKLQ

Nucleotide


Download         Length: 1344 bp        

>NTDB_id=1140031 DQM65_RS03340 WP_111691236.1 648582..649925(-) (comE) [Haemophilus influenzae strain NCTC11931]
ATGAATAAATATCTTTTAAAGTGCGGTTATTTTTTAGTGTGTTTTTGTTTGCCATTAATCGTTTTTGCTAATTCCAAAAC
TGATAATGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCCCAAACATTGGAACAGTTGGCTTTTCAACAAGATG
TGAATTTAGTGATGGATGAAGCATTAGAAAGTAATATTTCATTGAGATTAGATAATATTGATATGCCACGTTTGCTACAA
ATAATCGCAAAAAGTAAGCATCTTAGGCTGAATAAAGACGACGATATTTATTATCTGAATGGAGGGCAATCAGGCAAAGG
TCAAGTTGCAGGAAATCTTACTACAAATGAACCGCACTTAGTGAGCCATACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAGTCCTTAACCACAGGGAGCGGTTCTTTGCTTTCTCCTACAGGGAGCATTACCTTTGATGATCGTAGTAAT
TTGCTGGTTATTCAGGATGATCCTCGTTCTGTACAAAATATCAAAAAACTAATTTCTGAAATGGATAAACCTATTGAGCA
GATTGCTATTGAAGCGCGTATTGTGACGATAACAGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACGGAAAATGCAAGACGAGTTGCGGGCAGTCTTGTAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCGATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTCGATTTAGAATT
AAGCGCGTTAGAGCGTGAAAATAATGTGGAAATTATCGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTATATTGTGAGCAATACTCGTAACGATACGCAATCAGTGGAATTTCGCGAGGCGGTG
CTTGGTTTGGAAGTGACGCCACATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTCAGCAAAGAAAGCGAACGACATCAAAAACGTGAGCTCGTGATTTTCGTGACGCCGCATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAGCAAAAAAGTGCGGGGAAAAAGTTACAATGA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

95.73

99.553

0.953
  comE Haemophilus influenzae 86-028NP

95.506

99.553

0.951
  comE Glaesserella parasuis strain SC1401

51.508

96.421

0.497
  pilQ Vibrio campbellii strain DS40M4

42.959

93.736

0.403
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

42.233

92.17

0.389
  pilQ Vibrio cholerae strain A1552

42.233

92.17

0.389

Multiple sequence alignment