Detailed information NTG1139956

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQN61_RS00330
• Genome accession: NZ_LS483391
• Coordinates: 53162..54073 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8320
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48162..59073

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN61_RS00310 (NCTC8320_00062)	purE	48456..48947 (+)	492	WP_023079557.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQN61_RS00315 (NCTC8320_00063)	purK	48934..50007 (+)	1074	WP_023079558.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQN61_RS00320 (NCTC8320_00064)	-	50028..51368 (+)	1341	WP_011017237.1	hypothetical protein	-
DQN61_RS00325 (NCTC8320_00065)	purB	51737..53029 (+)	1293	WP_011017238.1	adenylosuccinate lyase	-
DQN61_RS00330 (NCTC8320_00066)	comR	53162..54073 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQN61_RS10135 (NCTC8320_00067)	comS	54158..54253 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQN61_RS00335 (NCTC8320_00068)	ruvB	54300..55298 (+)	999	WP_023079556.1	Holliday junction branch migration DNA helicase RuvB	-
DQN61_RS00340 (NCTC8320_00069)	-	55436..55873 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQN61_RS00345 (NCTC8320_00070)	-	55896..56297 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
DQN61_RS00350 (NCTC8320_00071)	-	56294..58069 (+)	1776	WP_011017241.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1139956 DQN61_RS00330 WP_002986681.1 53162..54073(+) (comR) [Streptococcus pyogenes strain NCTC8320]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1139956 DQN61_RS00330 WP_002986681.1 53162..54073(+) (comR) [Streptococcus pyogenes strain NCTC8320]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462