Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQM63_RS04705 Genome accession   NZ_LS483385
Coordinates   953131..953805 (+) Length   224 a.a.
NCBI ID   WP_002897753.1    Uniprot ID   A0A2X4AMM1
Organism   Streptococcus sanguinis strain NCTC7863     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 938492..964134 953131..953805 within 0


Gene organization within MGE regions


Location: 938492..964134
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM63_RS04635 (NCTC7863_00909) - 938492..939082 (+) 591 WP_002913665.1 hypothetical protein -
  DQM63_RS04640 (NCTC7863_00910) - 939211..939753 (+) 543 WP_002913664.1 hypothetical protein -
  DQM63_RS04645 (NCTC7863_00911) - 940011..940640 (+) 630 WP_002913663.1 hypothetical protein -
  DQM63_RS04655 (NCTC7863_00913) - 940909..941538 (+) 630 WP_032909734.1 hypothetical protein -
  DQM63_RS04660 - 941529..942871 (+) 1343 Protein_871 hypothetical protein -
  DQM63_RS04665 (NCTC7863_00916) - 942882..943178 (+) 297 WP_002895761.1 hypothetical protein -
  DQM63_RS04670 (NCTC7863_00917) - 943187..943513 (+) 327 WP_002912237.1 hypothetical protein -
  DQM63_RS04675 (NCTC7863_00918) - 943682..946222 (+) 2541 WP_002913662.1 M1 family metallopeptidase -
  DQM63_RS04680 (NCTC7863_00919) - 946375..950577 (+) 4203 WP_002913661.1 GbpC/Spa domain-containing protein -
  DQM63_RS04685 (NCTC7863_00920) - 950845..951129 (+) 285 WP_002900560.1 helix-turn-helix domain-containing protein -
  DQM63_RS04690 (NCTC7863_00921) - 951185..951511 (+) 327 WP_002900559.1 multidrug efflux SMR transporter -
  DQM63_RS04695 (NCTC7863_00922) - 951515..952330 (+) 816 WP_002900558.1 SDR family oxidoreductase -
  DQM63_RS04700 (NCTC7863_00923) - 952511..953026 (+) 516 WP_002902799.1 hypothetical protein -
  DQM63_RS04705 (NCTC7863_00924) ciaR 953131..953805 (+) 675 WP_002897753.1 response regulator transcription factor Regulator
  DQM63_RS04710 (NCTC7863_00925) ciaH 953795..955186 (+) 1392 WP_002913659.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DQM63_RS04715 (NCTC7863_00926) - 955202..956140 (+) 939 WP_002900555.1 ketopantoate reductase family protein -
  DQM63_RS04720 (NCTC7863_00927) - 956252..956638 (+) 387 WP_002895748.1 VOC family protein -
  DQM63_RS04725 (NCTC7863_00928) - 956700..958097 (+) 1398 WP_002900553.1 polysaccharide deacetylase family protein -
  DQM63_RS04730 (NCTC7863_00929) - 958191..959282 (-) 1092 WP_002912245.1 DEAD/DEAH box helicase -
  DQM63_RS04735 (NCTC7863_00930) - 959272..960282 (-) 1011 WP_002900551.1 Gfo/Idh/MocA family protein -
  DQM63_RS04740 (NCTC7863_00931) udk 960362..960997 (+) 636 WP_032909529.1 uridine kinase -
  DQM63_RS04745 (NCTC7863_00932) - 961163..961807 (+) 645 WP_002900549.1 YoaK family protein -
  DQM63_RS11650 - 961913..962370 (+) 458 Protein_889 hypothetical protein -
  DQM63_RS04760 (NCTC7863_00935) - 962514..962969 (+) 456 WP_002900546.1 hypothetical protein -
  DQM63_RS04765 (NCTC7863_00936) - 963119..963553 (+) 435 WP_002900545.1 hypothetical protein -
  DQM63_RS04770 (NCTC7863_00937) - 963697..964134 (+) 438 WP_002900544.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25209.95 Da        Isoelectric Point: 4.4858

>NTDB_id=1139630 DQM63_RS04705 WP_002897753.1 953131..953805(+) (ciaR) [Streptococcus sanguinis strain NCTC7863]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLRAKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLSYGDVTVNLSTNSTTKAGKDVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTAFAKNLHTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1139630 DQM63_RS04705 WP_002897753.1 953131..953805(+) (ciaR) [Streptococcus sanguinis strain NCTC7863]
ATGATTAAAATTCTATTGGTAGAAGATGACCTTGGACTGTCAAACTCAGTTTTTGATTTTTTAGATGATTTTGCAGATGT
AATGCAGGTTTTTGATGGTGAAGAAGGTCTATATGAAGCAGAAAGCGGTGTTTATGACCTCATCTTACTGGATCTCATGT
TGCCTGAAAAGGATGGTTTCCAAGTGCTGAAAGATCTCCGAGCAAAAGGGGTTACAACCCCTGTTCTCATCATGACAGCT
AAGGAAAGCTTGGATGACAAAGGACATGGCTTTGAGCTCGGCGCTGACGACTATCTGACAAAACCTTTCTATTTGGAAGA
ACTGAAAATGCGGATCCAAGCGCTCTTGAAACGCGCTGGTAAATTCAACGAGAATACTCTTTCTTATGGTGATGTGACTG
TCAACCTATCTACAAATTCAACCACGAAGGCGGGTAAAGATGTAGAGTTGCTTGGTAAAGAGTTCGACCTCTTGGTTTAT
TTCCTGCAAAATCAAAATGTAATCTTGCCTAAGACTCAAATTTTTGACCGTCTGTGGGGCTTTGACAGTGATACCACTGT
TTCCGTTGTCGAAGTGTACGTTTCAAAGATTCGTAAAAAACTGAAAGGAACGGCATTTGCGAAAAACCTACATACTCTTC
GTAGTGTCGGCTACATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4AMM1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

88.839

100

0.888
  ciaR Streptococcus pneumoniae D39

88.839

100

0.888
  ciaR Streptococcus pneumoniae R6

88.839

100

0.888
  ciaR Streptococcus pneumoniae TIGR4

88.839

100

0.888
  ciaR Streptococcus mutans UA159

87.444

99.554

0.871
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment