Detailed information NTG1139586

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQM87_RS07250
• Genome accession: NZ_LS483384
• Coordinates: 1420161..1422314 (+)
• Length: 717 a.a.
• NCBI ID: WP_020833322.1
• Uniprot ID: A0AAE9R0J2
• Organism: Streptococcus pyogenes strain NCTC13743
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1415161..1427314

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM87_RS07205 (NCTC13743_01448)	stcA	1415589..1415858 (+)	270	WP_023605037.1	quorum-sensing system protein StcA	-
DQM87_RS07210 (NCTC13743_01449)	-	1416206..1416604 (-)	399	WP_032464238.1	hypothetical protein	-
DQM87_RS07215 (NCTC13743_01450)	-	1416697..1417767 (-)	1071	WP_111705177.1	hypothetical protein	-
DQM87_RS07220 (NCTC13743_01451)	-	1417985..1418419 (-)	435	WP_032465693.1	hypothetical protein	-
DQM87_RS09800 (NCTC13743_01452)	-	1418598..1418894 (-)	297	WP_002985722.1	hypothetical protein	-
DQM87_RS07240 (NCTC13743_01454)	-	1419434..1419634 (-)	201	WP_002985729.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
DQM87_RS07245 (NCTC13743_01455)	-	1419647..1419874 (-)	228	WP_002992018.1	Blp family class II bacteriocin	-
DQM87_RS07250 (NCTC13743_01456)	comA/nlmT	1420161..1422314 (+)	2154	WP_020833322.1	peptide cleavage/export ABC transporter	Regulator
DQM87_RS07255 (NCTC13743_01457)	-	1422325..1423689 (+)	1365	WP_014635340.1	bacteriocin secretion accessory protein	-
DQM87_RS07260 (NCTC13743_01458)	-	1423766..1423891 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DQM87_RS07265 (NCTC13743_01459)	-	1424039..1425373 (-)	1335	WP_014635339.1	sensor histidine kinase	-
DQM87_RS07270 (NCTC13743_01460)	comE/blpR	1425374..1426123 (-)	750	WP_002992578.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80543.45 Da
• Isoelectric Point: 7.0109

>NTDB_id=1139586 DQM87_RS07250 WP_020833322.1 1420161..1422314(+) (comA/nlmT) [Streptococcus pyogenes strain NCTC13743]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLINFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=1139586 DQM87_RS07250 WP_020833322.1 1420161..1422314(+) (comA/nlmT) [Streptococcus pyogenes strain NCTC13743]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGGTTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAACTTTTTACCTCTT
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAATTACCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACCAAACTTCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAATTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	73.007	99.721	0.728
comA	Streptococcus mitis NCTC 12261	67.651	99.163	0.671
comA	Streptococcus mitis SK321	67.229	99.163	0.667
comA	Streptococcus pneumoniae Rx1	67.229	99.163	0.667
comA	Streptococcus pneumoniae D39	67.229	99.163	0.667
comA	Streptococcus pneumoniae R6	67.229	99.163	0.667
comA	Streptococcus pneumoniae TIGR4	66.948	99.163	0.664
comA	Streptococcus gordonii str. Challis substr. CH1	66.154	99.721	0.66