Detailed information NTG1139546

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQM87_RS00335
• Genome accession: NZ_LS483384
• Coordinates: 53159..54070 (+)
• Length: 303 a.a.
• NCBI ID: WP_023611326.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC13743
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48159..59070

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM87_RS00315 (NCTC13743_00062)	purE	48463..48954 (+)	492	WP_111704865.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQM87_RS00320 (NCTC13743_00063)	purK	48941..50014 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQM87_RS09755	-	50035..51364 (+)	1330	Protein_30	hypothetical protein	-
DQM87_RS00330 (NCTC13743_00066)	purB	51733..53025 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
DQM87_RS00335 (NCTC13743_00067)	comR	53159..54070 (+)	912	WP_023611326.1	transcriptional regulator Rgg4/ComR	Regulator
DQM87_RS09830 (NCTC13743_00068)	comS	54154..54249 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQM87_RS00340 (NCTC13743_00069)	ruvB	54296..55294 (+)	999	WP_063629365.1	Holliday junction branch migration DNA helicase RuvB	-
DQM87_RS00345 (NCTC13743_00070)	-	55432..55869 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
DQM87_RS00350 (NCTC13743_00071)	-	55892..56293 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
DQM87_RS00355 (NCTC13743_00072)	-	56290..58065 (+)	1776	WP_021733211.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35685.21 Da
• Isoelectric Point: 4.5164

>NTDB_id=1139546 DQM87_RS00335 WP_023611326.1 53159..54070(+) (comR) [Streptococcus pyogenes strain NCTC13743]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSGQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1139546 DQM87_RS00335 WP_023611326.1 53159..54070(+) (comR) [Streptococcus pyogenes strain NCTC13743]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGGACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.67	100	0.997
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462