Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQM69_RS08865 Genome accession   NZ_LS483381
Coordinates   1823233..1825107 (-) Length   624 a.a.
NCBI ID   WP_109982746.1    Uniprot ID   -
Organism   Streptococcus sobrinus strain NCTC10921     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1818233..1830107
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM69_RS08840 (NCTC10921_01759) - 1818538..1818888 (-) 351 WP_109982744.1 S1 RNA-binding domain-containing protein -
  DQM69_RS08845 (NCTC10921_01760) - 1818888..1820285 (-) 1398 WP_109982745.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQM69_RS08850 (NCTC10921_01761) - 1820389..1821039 (-) 651 WP_019770084.1 response regulator -
  DQM69_RS08855 (NCTC10921_01762) - 1821017..1822060 (-) 1044 WP_021673931.1 sensor histidine kinase -
  DQM69_RS08860 (NCTC10921_01763) liaF 1822057..1822755 (-) 699 WP_019770059.1 cell wall-active antibiotics response protein LiaF -
  DQM69_RS08865 (NCTC10921_01764) pknB 1823233..1825107 (-) 1875 WP_109982746.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQM69_RS08870 (NCTC10921_01765) - 1825104..1825847 (-) 744 WP_002960300.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQM69_RS08875 (NCTC10921_01766) rsmB 1825997..1827322 (-) 1326 WP_109982747.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQM69_RS08880 (NCTC10921_01767) fmt 1827306..1828241 (-) 936 WP_019769792.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 624 a.a.        Molecular weight: 67412.65 Da        Isoelectric Point: 6.5267

>NTDB_id=1139411 DQM69_RS08865 WP_109982746.1 1823233..1825107(-) (pknB) [Streptococcus sobrinus strain NCTC10921]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILEGEEVAIKVLRTNYQTDQVAVTRFQREARAMAELSHPNIVSIRDIG
EEDGQQFLVMEYVDGLDLKHYIQEKAPLSNSEVVRIMEEVLSAMTLAHEKGIIHRDLKPQNILLTKEGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIREINSEVP
QALENVVIKATAKRLTDRYQSTYEMSRDLMSSLSYNRSREAKLVFSDVADTKTLPKIDTNTANASTEQLLKATDKNAKAK
EPANPAPKKKVKPKRKHKASVFSKVAIGVALVLIALVAFFMLRNPSSVSVPDVSGQDLSTARSTIKKSGFKVGQVIKVES
DSVAKGKVVRTDPAAGSSKKEGTSVDIYVSGSGSKFKMRDYTGKDIDTVKKELESDYGVKESQIEVTEVSTSDYDEGTII
SQSPSKGDKFDTSGDDTIKFTVAVSGSTTMPNLTGMTYSQAISTLTAIGVKSSRIKIYSSSTGSETSPSSSSIISGQNPY
YGASLDLSSSDEIVLYVQDASSRSSSSSSSTSSNSSSSSSSSSSENPQQDDSDNSNSSESNGNQ

Nucleotide


Download         Length: 1875 bp        

>NTDB_id=1139411 DQM69_RS08865 WP_109982746.1 1823233..1825107(-) (pknB) [Streptococcus sobrinus strain NCTC10921]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGCTATCGCATCCTCAAGTCCATCGGTCGAGGTGGGATGGCCGACGTTTA
CTTGGCTAACGATCTGATTTTAGAAGGAGAAGAAGTTGCCATCAAGGTACTTCGAACTAACTATCAGACCGACCAAGTCG
CTGTGACTCGTTTTCAGCGAGAAGCGCGGGCCATGGCTGAACTCAGCCACCCTAATATCGTTTCTATTAGAGATATTGGC
GAAGAAGATGGACAGCAATTCCTAGTAATGGAATACGTCGATGGTTTAGACCTCAAGCATTATATTCAAGAAAAGGCGCC
ATTATCCAATTCTGAAGTTGTCAGGATTATGGAAGAAGTCCTTTCAGCTATGACCCTGGCCCATGAGAAAGGAATCATTC
ACCGGGACCTCAAGCCTCAGAATATTCTTTTAACCAAGGAGGGCACAGTCAAAGTTACTGACTTCGGAATTGCCGTGGCC
TTTGCGGAAACCAGCCTGACACAGACCAATTCTATGCTGGGTAGTGTCCACTATCTTTCGCCAGAACAGGCGCGTGGTTC
CAAAGCAACGGTCCAGTCCGATATTTATGCCATGGGAATTATGCTCTTTGAAATGCTGACAGGTCACATTCCTTATGATG
GCGACAGTGCCGTGACCATTGCCCTCCAGCATTTTCAAAAACCCCTGCCTTCCATTAGAGAAATCAATTCAGAGGTTCCC
CAAGCCTTGGAAAATGTTGTCATTAAGGCAACAGCAAAAAGGTTGACGGATCGTTATCAATCGACCTATGAAATGAGTCG
AGACCTCATGTCTAGTCTCAGCTATAACCGTAGCCGAGAAGCTAAATTGGTCTTTTCAGATGTGGCAGATACTAAAACCC
TGCCTAAGATTGATACTAATACAGCTAACGCTTCCACAGAGCAGCTGCTGAAGGCTACCGATAAGAATGCTAAGGCTAAG
GAGCCTGCAAATCCAGCACCTAAGAAAAAGGTTAAACCTAAGCGTAAGCATAAGGCTAGTGTCTTTAGCAAGGTTGCAAT
CGGTGTAGCCCTAGTGTTGATTGCACTGGTTGCCTTCTTCATGTTGCGAAATCCATCTTCGGTTAGTGTCCCAGATGTTT
CTGGACAGGATTTATCAACAGCTCGATCAACTATTAAGAAATCCGGTTTTAAAGTCGGCCAAGTCATTAAGGTAGAGAGT
GATTCTGTTGCTAAGGGTAAGGTTGTTCGGACCGACCCTGCTGCAGGAAGTTCGAAAAAAGAGGGAACCTCGGTCGATAT
CTATGTTTCTGGAAGTGGCAGTAAATTTAAGATGAGGGACTACACCGGCAAAGATATTGACACTGTCAAGAAGGAATTAG
AGTCTGATTATGGTGTCAAAGAGTCCCAGATAGAGGTGACGGAAGTTTCCACATCTGATTACGATGAGGGCACCATCATC
AGTCAAAGCCCTTCTAAGGGAGATAAATTTGATACCTCAGGTGATGATACCATTAAATTTACGGTTGCTGTTTCAGGGTC
AACAACCATGCCTAATTTAACAGGGATGACTTATTCTCAGGCAATTTCTACCCTGACAGCCATTGGTGTTAAATCGTCAC
GGATTAAGATTTATTCATCATCAACAGGATCTGAAACCTCCCCTTCATCATCTAGCATCATTTCTGGACAAAATCCATAC
TATGGAGCTAGCCTAGATTTATCATCTAGCGACGAGATTGTTCTCTATGTACAGGATGCTTCATCGAGGTCATCCAGCTC
ATCAAGTTCAACGTCATCGAATTCGTCAAGTTCATCAAGTTCATCAAGTTCAGAAAATCCCCAACAAGATGATAGTGACA
ACTCAAATTCGTCTGAAAGCAACGGGAATCAATGA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(368-431)

PASTA domain (PASTA)

(509-577)

PASTA domain (PASTA)

(437-503)

Protein kinase domain (Pkinase)

(12-256)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

66.954

93.109

0.623
  stkP/pknB Streptococcus salivarius strain HSISS4

62.331

94.872

0.591
  stkP Streptococcus pneumoniae TIGR4

54.889

93.429

0.513
  stkP Streptococcus pneumoniae D39

54.889

93.429

0.513
  stkP Streptococcus pneumoniae R6

54.889

93.429

0.513
  stkP Streptococcus pneumoniae Rx1

54.717

93.429

0.511

Multiple sequence alignment