Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQM69_RS04270 Genome accession   NZ_LS483381
Coordinates   883720..884394 (+) Length   224 a.a.
NCBI ID   WP_002961524.1    Uniprot ID   U2KC16
Organism   Streptococcus sobrinus strain NCTC10921     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 878720..889394
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM69_RS04255 (NCTC10921_00837) pstB 879354..880112 (+) 759 WP_002961529.1 phosphate ABC transporter ATP-binding protein PstB -
  DQM69_RS04260 (NCTC10921_00838) phoU 880152..880805 (+) 654 WP_002961527.1 phosphate signaling complex protein PhoU -
  DQM69_RS04265 (NCTC10921_00839) - 880912..883455 (+) 2544 WP_109982554.1 M1 family metallopeptidase -
  DQM69_RS04270 (NCTC10921_00840) ciaR 883720..884394 (+) 675 WP_002961524.1 response regulator transcription factor Regulator
  DQM69_RS04275 (NCTC10921_00841) ciaH 884384..885769 (+) 1386 WP_019769637.1 sensor histidine kinase Regulator
  DQM69_RS04280 (NCTC10921_00842) rpsT 885884..886132 (-) 249 WP_019772096.1 30S ribosomal protein S20 -
  DQM69_RS04285 (NCTC10921_00843) coaA 886185..887105 (-) 921 WP_002961520.1 type I pantothenate kinase -
  DQM69_RS04290 (NCTC10921_00844) - 887170..887760 (+) 591 WP_019777495.1 class I SAM-dependent methyltransferase -
  DQM69_RS04295 (NCTC10921_00845) - 887757..889034 (+) 1278 WP_019785613.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25369.21 Da        Isoelectric Point: 4.3647

>NTDB_id=1139392 DQM69_RS04270 WP_002961524.1 883720..884394(+) (ciaR) [Streptococcus sobrinus strain NCTC10921]
MIKILLVEDDLSLSNSVYDFLDDFAEVTQVFDGEEGLFEAETGVYDLILLDLMLPEKDGFTVLKELRDKGVATPVLITTA
KEALDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKINDKLLTYGDLECDTSTNTVTVNGKIVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTVSVVEVYVSKIRKKLKGTDFEKCLQTLRSVGYILKDVK

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1139392 DQM69_RS04270 WP_002961524.1 883720..884394(+) (ciaR) [Streptococcus sobrinus strain NCTC10921]
ATGATTAAAATTTTATTAGTAGAAGATGATTTAAGTCTTTCAAATTCCGTCTATGATTTTCTAGATGACTTTGCTGAAGT
TACCCAAGTCTTTGATGGAGAAGAAGGCCTATTTGAAGCAGAAACTGGTGTTTATGACTTGATTCTGCTTGATTTGATGT
TGCCAGAAAAAGATGGTTTCACCGTTCTTAAGGAATTACGTGATAAGGGTGTTGCAACCCCTGTTTTGATTACAACCGCC
AAAGAAGCACTTGATGATAAAGGACATGGTTTTGAACTGGGTGCCGATGATTATCTGACCAAGCCTTTCTACTTGGAAGA
ATTAAAGATGCGGATTCAGGCCCTTTTGAAGCGTTCAGGTAAAATCAATGATAAGTTGCTGACCTATGGCGATTTAGAAT
GTGATACCTCCACTAATACCGTTACTGTAAATGGTAAGATTGTCGAATTGTTGGGTAAGGAATTTGACCTCTTGGTTTAT
TTCTTGCAAAATCAAAATGTTATCTTACCTAAGACACAAATTTTTGATAGAATTTGGGGCTTTGATAGTGATACAACAGT
TTCTGTTGTTGAGGTCTATGTTTCTAAGATTCGTAAAAAATTAAAGGGGACGGATTTCGAAAAATGTCTACAAACACTGC
GCAGTGTGGGGTATATTCTAAAGGATGTTAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(148-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2KC16

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.268

100

0.853
  ciaR Streptococcus pneumoniae Rx1

83.482

100

0.835
  ciaR Streptococcus pneumoniae D39

83.482

100

0.835
  ciaR Streptococcus pneumoniae R6

83.482

100

0.835
  ciaR Streptococcus pneumoniae TIGR4

83.482

100

0.835
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.004

100

0.375

Multiple sequence alignment