Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DQM55_RS02230 Genome accession   NZ_LS483364
Coordinates   429976..430728 (+) Length   250 a.a.
NCBI ID   WP_048774117.1    Uniprot ID   A0A2X4AGF0
Organism   Streptococcus sanguinis strain NCTC11086     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 424976..435728
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM55_RS02215 (NCTC11086_00439) - 425226..426791 (-) 1566 WP_023917191.1 ABC transporter substrate-binding protein/permease -
  DQM55_RS02220 (NCTC11086_00440) - 426923..428818 (+) 1896 WP_023917189.1 DUF2207 domain-containing protein -
  DQM55_RS02225 (NCTC11086_00441) - 428958..429800 (+) 843 WP_048774115.1 undecaprenyl-diphosphate phosphatase -
  DQM55_RS02230 (NCTC11086_00442) mecA 429976..430728 (+) 753 WP_048774117.1 adaptor protein MecA Regulator
  DQM55_RS02235 (NCTC11086_00443) - 430719..431885 (+) 1167 WP_060976600.1 glycosyltransferase family 4 protein -
  DQM55_RS02240 (NCTC11086_00444) sufC 431975..432745 (+) 771 WP_002893635.1 Fe-S cluster assembly ATPase SufC -
  DQM55_RS02245 (NCTC11086_00445) sufD 432787..434049 (+) 1263 WP_060976601.1 Fe-S cluster assembly protein SufD -
  DQM55_RS02250 (NCTC11086_00446) - 434090..435322 (+) 1233 WP_111675344.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 28759.40 Da        Isoelectric Point: 4.0190

>NTDB_id=1138649 DQM55_RS02230 WP_048774117.1 429976..430728(+) (mecA) [Streptococcus sanguinis strain NCTC11086]
MEMKQISDSTIKITIQLEDLEERGMEMADFLVPQEKTEEFFYTILDELEMPDNFLDSGMLSFRVTPKPDKVDVFVTKSKL
DKNLSFEDLADLPDMDELSHMSPDEFLKTLEKSIFEKSKEDIEAVQSLETAEAEEGAQFSQQAADEQLTENAERYIYYIL
RFEDIKAAAAFAQTVDYKIDLSELYKHDSAYYLTILVDVEGFPERYPAWLLAKMREFADDSDITRAVLQEHGHLLLVTDA
VSGLQKVECL

Nucleotide


Download         Length: 753 bp        

>NTDB_id=1138649 DQM55_RS02230 WP_048774117.1 429976..430728(+) (mecA) [Streptococcus sanguinis strain NCTC11086]
ATGGAAATGAAACAGATTAGTGATTCGACCATAAAAATCACGATTCAGCTGGAAGATTTGGAAGAACGTGGCATGGAAAT
GGCTGATTTCTTGGTCCCCCAAGAAAAGACAGAAGAGTTTTTCTATACCATCTTAGATGAGTTGGAAATGCCGGATAATT
TTTTGGACAGCGGTATGCTGAGTTTCCGTGTGACGCCTAAGCCAGACAAGGTAGATGTTTTTGTTACCAAGTCTAAATTA
GATAAGAATCTGAGTTTTGAGGATTTGGCAGATCTGCCAGACATGGATGAGCTGTCTCATATGTCTCCAGATGAATTCCT
CAAGACATTGGAAAAGAGCATTTTTGAAAAGAGTAAGGAAGACATAGAAGCAGTCCAATCTTTGGAAACAGCCGAAGCAG
AGGAAGGGGCGCAATTTTCTCAGCAGGCGGCCGATGAGCAGTTGACAGAAAATGCAGAGCGTTACATTTACTATATCCTG
CGTTTTGAAGATATTAAGGCTGCTGCGGCCTTTGCCCAGACGGTGGACTATAAGATTGACTTATCAGAGCTTTATAAGCA
TGATTCTGCTTATTATTTGACGATTTTAGTAGATGTTGAGGGTTTTCCAGAGCGCTATCCAGCTTGGCTCTTGGCCAAGA
TGCGTGAGTTTGCAGATGATTCAGATATCACTCGGGCGGTGCTTCAGGAGCACGGTCATCTGCTTTTGGTGACAGATGCG
GTCTCCGGCCTGCAGAAGGTTGAATGCCTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4AGF0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

68.016

98.8

0.672
  mecA Streptococcus pneumoniae D39

68.016

98.8

0.672
  mecA Streptococcus pneumoniae R6

68.016

98.8

0.672
  mecA Streptococcus pneumoniae TIGR4

67.611

98.8

0.668
  mecA Streptococcus mutans UA159

49.393

98.8

0.488
  mecA Streptococcus thermophilus LMD-9

47.843

100

0.488
  mecA Streptococcus thermophilus LMG 18311

47.451

100

0.484

Multiple sequence alignment