Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DQM53_RS08230 Genome accession   NZ_LS483361
Coordinates   1649137..1651032 (-) Length   631 a.a.
NCBI ID   WP_111717291.1    Uniprot ID   A0A9X8XG98
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC6179     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1644137..1656032
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM53_RS08205 (NCTC6179_01692) - 1644887..1645246 (-) 360 WP_111717284.1 S1 RNA-binding domain-containing protein -
  DQM53_RS08210 (NCTC6179_01693) - 1645246..1646646 (-) 1401 WP_111717286.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQM53_RS08215 (NCTC6179_01694) - 1646683..1647324 (-) 642 WP_014612503.1 response regulator transcription factor -
  DQM53_RS08220 (NCTC6179_01695) - 1647317..1648321 (-) 1005 WP_003061197.1 sensor histidine kinase -
  DQM53_RS08225 (NCTC6179_01696) liaF 1648318..1649010 (-) 693 WP_111717289.1 cell wall-active antibiotics response protein LiaF -
  DQM53_RS08230 (NCTC6179_01697) pknB 1649137..1651032 (-) 1896 WP_111717291.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQM53_RS08235 (NCTC6179_01698) - 1651029..1651769 (-) 741 WP_111717293.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQM53_RS08240 (NCTC6179_01699) rsmB 1651807..1653129 (-) 1323 WP_111717943.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DQM53_RS08245 (NCTC6179_01700) fmt 1653119..1654054 (-) 936 WP_111717295.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68859.29 Da        Isoelectric Point: 7.2901

>NTDB_id=1138538 DQM53_RS08230 WP_111717291.1 1649137..1651032(-) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6179]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPVTTPKVAPTPVTSTTESRL
EHTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPNVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPPTGTAKRKGSAITVYLSIGNKGFEMENYKGIDYQEAMASLMETYGVPKSKIKIERIVTNEYTEN
TVISQSPSSGDKFNPNGKYKITLSVAVSDTVIMPMVTEYTYADAVNTLTALGIEASRIKAYAPSSSSATGFVQVNSPSSK
AIVSGQTPYYGTTLSLSEKGEISLYLYPEETHSSSSSTSSEASSSISSTNDGTGTSSNTELSPSESTGQTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=1138538 DQM53_RS08230 WP_111717291.1 1649137..1651032(-) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6179]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTACGTACCAATTATCAGACAGATCAGGTAG
CGGTTGCCCGTTTCCAACGGGAAGCGCGTGCCATGGCTGAGTTAAACCATCCTAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATACGTAGATGGCGCTGACTTAAAGAAGTATATTCAAGATCATGCTCC
TCTATCCAATAATGAAGTGGTCAGAATCATGGAAGAGGTGCTTTCTGCCATGACATTAGCTCACCAGAAAGGGATTGTTC
ATAGAGATTTAAAACCTCAAAACATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGACTTTGGGATTGCCGTTGCT
TTTGCGGAAACGAGTTTGACTCAAACCAACTCTATGTTGGGAAGCGTCCATTACCTATCGCCTGAGCAGGCTCGCGGCTC
AAAAGCGACCATTCAAAGTGATATTTATGCGATGGGAATTATGCTCTTTGAAATGTTGACAGGACATATCCCTTATGATG
GCGATAGTGCTGTTACCATTGCTTTGCAACATTTCCAAAAGCCTCTTCCGTCTATTATTGACGAAAACCACAATGTACCG
CAAGCTTTAGAGAATGTGGTTATCCGAGCAACAGCTAAGAAATTAAGCGATCGTTACGGATCAACCTTTGAAATGAGTCG
TGATCTGATGACGGCTCTCAGTTACAACCGGAGTCGTGAACGGAAAGTTATTTTTGATGATGTGGAAAGCACAAAACCTC
TCCCTAAAGTAACACCGGCACCAGTAACGACGCCAAAAGTAGCTCCAACTCCTGTTACGTCCACAACTGAAAGTCGTTTA
GAACACACTAATCAGATGGATACACTCCAGAAACCACAAAAAAAGAAGCGAAATGGTCGTTTCTTGGGTACTTTGTTAAA
AATCCTCTTTTCTCTCTTTATTGTAGGTGTGGCTCTCTTCACTTACTTGGTGCTAACAAAACCTACCTCAGTAAAAGTTC
CTAATGTGACAGGTGTCAGTCTTAAAGTTGCAAAGCAGGAACTGCAAGATTTAGGCTTGAAAGTTGGTAAGGTGAGACAG
ATTGAAAGTGATACTGTTGCGGAAGGGAATGTTGTCCGAACAGATCCACCAACGGGAACAGCCAAGCGCAAGGGTTCAGC
TATCACAGTTTACTTGTCAATTGGCAATAAAGGGTTTGAGATGGAAAACTACAAAGGGATTGATTATCAAGAAGCCATGG
CTAGCTTGATGGAAACCTACGGTGTTCCTAAATCGAAGATTAAGATTGAACGAATCGTGACCAATGAATACACGGAAAAT
ACTGTTATTAGCCAATCTCCGAGTTCAGGGGATAAATTTAATCCTAATGGGAAATATAAAATTACTCTTAGTGTTGCCGT
GAGTGACACAGTCATTATGCCTATGGTAACAGAATATACCTATGCTGATGCAGTAAATACTTTGACAGCATTAGGTATTG
AAGCTTCGAGGATTAAAGCTTATGCTCCAAGCTCAAGTTCAGCAACAGGTTTTGTTCAGGTTAATTCTCCAAGTTCAAAA
GCTATTGTCAGTGGTCAAACCCCTTATTACGGTACCACTTTGAGCCTCTCTGAAAAAGGTGAGATAAGCCTTTACCTTTA
CCCAGAAGAAACGCATTCTTCAAGTAGTTCAACCAGTTCTGAGGCAAGTTCTAGCATTTCCTCAACAAATGATGGAACGG
GAACAAGTAGTAATACTGAATTAAGCCCATCGGAATCAACTGGTCAAACCCCTTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-233)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(511-587)

PASTA domain (PASTA)

(371-433)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.358

92.868

0.607
  stkP/pknB Streptococcus salivarius strain HSISS4

62.017

94.295

0.585
  stkP Streptococcus pneumoniae TIGR4

58.221

81.933

0.477
  stkP Streptococcus pneumoniae D39

58.027

81.933

0.475
  stkP Streptococcus pneumoniae R6

58.027

81.933

0.475
  stkP Streptococcus pneumoniae Rx1

57.834

81.933

0.474

Multiple sequence alignment