Detailed information NTG1138439

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQM47_RS00330
• Genome accession: NZ_LS483360
• Coordinates: 53254..54165 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC10876
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48254..59165

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM47_RS00310 (NCTC10876_00062)	purE	48535..49026 (+)	492	WP_023079042.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DQM47_RS00315 (NCTC10876_00063)	purK	49013..50086 (+)	1074	WP_023610834.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DQM47_RS00320 (NCTC10876_00064)	-	50113..51810 (+)	1698	WP_020904816.1	AIPR family protein	-
DQM47_RS00325 (NCTC10876_00065)	purB	51828..53120 (+)	1293	WP_023079043.1	adenylosuccinate lyase	-
DQM47_RS00330 (NCTC10876_00066)	comR	53254..54165 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
DQM47_RS10200 (NCTC10876_00067)	comS	54249..54344 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
DQM47_RS00335 (NCTC10876_00068)	ruvB	54391..55389 (+)	999	WP_014407198.1	Holliday junction branch migration DNA helicase RuvB	-
DQM47_RS00340 (NCTC10876_00069)	-	55527..55964 (+)	438	WP_111695793.1	low molecular weight protein-tyrosine-phosphatase	-
DQM47_RS00345 (NCTC10876_00070)	-	55987..56388 (+)	402	WP_032465955.1	MORN repeat-containing protein	-
DQM47_RS00350 (NCTC10876_00071)	-	56385..58160 (+)	1776	WP_023610835.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1138439 DQM47_RS00330 WP_002986681.1 53254..54165(+) (comR) [Streptococcus pyogenes strain NCTC10876]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1138439 DQM47_RS00330 WP_002986681.1 53254..54165(+) (comR) [Streptococcus pyogenes strain NCTC10876]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAACTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462